National Institute of Neurological Disorders and Stroke (NINDS)s

National Institute of Neurological Disorders and Stroke (NINDS)

94 Protocols (53 Active Accrual of new subjects, 41 Follow-up of previously enrolled subjects)

 002067-N:

Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection

 001925-N:

Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort

 001861-N:

Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals with History of Stroke

 001719-N:

Ultra-Low Field (ULF) Point Of Care (POC) MRI System for Study Brain Morphology and Pathology

 001642-N:

ALLFTD: ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration

 001608-N:

Pre-operative vs. Post-operative Stereotactic Radiosurgery for Operative Metastatic Brain Tumors

 001519-N:

Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy: A Pilot Study

 000865-N:

Natural History Protocol for Movement Disorders

 000784-N:

Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects

 000711-N:

Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 (IN-PASC)

 000642-N:

Phase II Trial of Non-Invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in Functional Movement Disorders

 000625-N:

Investigational use of Neuromuscular Ultrasound

 000560-N:

Data Collection of Standard Care of Patients in the EMG Section

 000428-N:

An Observational Study to Assess Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)

 000126-N:

A Pilot Study of NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients with Progressive Multifocal Leukoencephalopathy

 000089-N:

Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health

 000051-N:

NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

 21-N-0016:

Phase I/II Study of Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

 21-N-0010:

A Phase 2 Clinical Trial of Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

 20-N-0064:

An observational study to assess clinical manifestations and biomarkers in amyotrophic lateral sclerosis type 4, other inherited neurological disorders with RNA Processing Defects, and Other Neurological Diseases with a Gain of Function Mechanism.

 20-N-0060:

Mechanisms Underlying the Beneficial Effects of Naps on Motor Learning

 20-N-0019:

The Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing's Disease

 18-N-0133:

Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery

 18-N-0066:

Investigating Epilepsy: Screening and Evaluation

 17-N-0168:

Influence of Brain Oscillation-Dependent TMS on Motor Function

 17-N-0131:

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

 16-N-0114:

The Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques: An Investigator-Blinded Study

 16-N-0055:

The Pathological Basis of MRI Signal Changes in Multiple Sclerosis: A Longitudinal In Vivo-to-Postmortem Study

 16-N-0041:

Tumor Related Epilepsy

 16-N-0031:

An All-Night Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli

 15-N-0177:

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

 15-N-0125:

Natural History Study of Inflammatory and Infectious Diseases of the Nervous System

 15-N-0081:

A Study of Direct Brain Recording and Stimulation for Memory Enhancement

 15-N-0073:

A Phase I Study of Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

 14-N-0086:

Deep Brain Stimulation Therapy in Movement Disorders

 14-N-0061:

Noninvasive Pre-surgical Evaluation of Patients with Focal Epilepsy and Establishment of a Normative Imaging Database

 13-N-0165:

Electrical Impedance Myography: Natural History Studies in Neuromuscular Disorders and Healthy Volunteers

 13-N-0149:

An Evaluation of HIV-associated Neurocognitive Disorders (HAND) in Virologically Controlled Patients

 13-N-0140:

Cerebrospinal Fluid Collection and Repository Storage

 13-N-0017:

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

 12-N-0095:

Clinical and Molecular Manifestations of Neuromuscular and Neurogenetic Disorders of Childhood

 11-N-0211:

Deep Brain Stimulation Surgery for Movement Disorders

 11-N-0051:

Surgery as a Treatment for Medically Intractable Epilepsy

 09-N-0039:

A Phase I Study of the Intrathecal Administration of Resiniferatoxin for Treating Severe Refractory Pain Associated with Advanced Cancer

 08-N-0044:

A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2).

 03-N-0164:

Evaluation and Treatment of Neurosurgical Disorders

 01-N-0206:

Phenotype/Genotype Correlations in Movement Disorders

 01-N-0007:

Evaluation, Pathogenesis, and Treatment of Patients with or at Risk for Cerebrovascular Disease (A Natural History/Disease Pathogenesis Protocol)

 00-N-0082:

Characterization of Brain Morphology and Activity Using Functional and Anatomical MRI Contrast

 00-N-0043:

Clinical and Molecular Manifestations of Inherited Neurological Disorders

 98-N-0047:

Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)

 89-N-0045:

Evaluation of Progression in Multiple Sclerosis by Magnetic Resonance Imaging (MRI)

 85-N-0195:

Botulinum Toxin for the Treatment of Neurological Disorders

 002093-N:

A Single Center Prospective Natural History and Outcome Measure Validation Study of Congenital Myasthenic Syndromes

 002017-N:

Predicting Future Errors During Skill Performance

 001505-N:

A Phase 1/2a, Randomized, Double-Blind, Placebo-Controlled, First In-Patient Study of AJ201 to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Adults With Spinal and Bulbar Muscular Atrophy (SBMA)

 000196-N:

Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory

 000094-N:

An Observational Study of Neurologic Function After COVID -19 Infection

 20-N-0105:

Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

 20-N-0077:

Study of Volition: Behavioral analysis and Clinical Neurophysiological Analysis

 20-N-0048:

Corticotrophin-Releasing Hormone (CRH) Stimulation for 18F-FDG-PET Detection of Pituitary Adenoma in Cushing's Disease

 19-N-0124:

Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

 19-N-0036:

Exploring the Relationship Between Brain Asymmetry and Attention

 18-N-0140:

Clinical Laboratory Evaluation of Chronic Autonomic Failure

 18-N-0083:

ASPIRO: A Phase 1/2/3, Randomized, Open-Label, Ascending-Dose, Delayed-Treatment Concurrent Control Clinical Study to Evaluate the Safety and Efficacy of AT132, an AAV8-Delivered Gene Therapy in X-Linked Myotubular Myopathy (XLMTM) Patients

 18-N-0077:

Cytokine Microdialysis For Real Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade

 18-N-0020:

The Natural History of Blood-Brain Barrier Disruption in Stroke Patients with White Matter Hyperintensities (A Cohort Study)

 17-N-0145:

PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection

 17-N-0035:

Clinical and Physiological Studies of Tremor Syndromes

 16-N-0166:

Deep Brain Stimulation Surgery for Treatment of Focal Hand Dystonia

 16-N-0072:

A Pilot Study of Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy with Ex Vivo Generated Polyomavirus-Specific T-cells

 16-N-0064:

Cholinergic Receptor Imaging in Dystonia

 16-N-0058:

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

 15-N-0175:

An Open-Label, Phase 1b Safety and Efficacy Trial of Periganglionic Resiniferatoxin for the Treatment of Intractable Pain due to Cancer-induced Bone Pain

 15-N-0156:

In Vivo Characterization of Inflammation with Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging

 15-N-0126:

HERV-K Suppression using Antiretroviral Therapy in Volunteers with Amyotrophic Lateral Sclerosis (ALS)

 14-N-0083:

Neural Basis of Decision Making Deficits in Traumatic Brain Injury

 13-N-0188:

Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

 12-N-0137:

A Phase 1 Open-Label Dose Escalation Safety Study of Convection Enhanced Delivery (CED) of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor (AAV2-GDNF) in Subjects with Advanced Parkinson's Disease

 12-N-0122:

Integrating Genetic and Environmental Risk Scores into an Algorithm to Predict Multiple Sclerosis Susceptibility

 12-N-0083:

The Effectiveness of Botulinum Toxin on Persistent Pelvic Pain in Women with Endometriosis

 12-N-0031:

Imaging Biomarkers in Parkinson Disease

 11-N-0210:

NIB Repository Protocol

 11-N-0084:

Evaluation and Diagnosis of Potential Research Subjects with Traumatic Brain Injury (TBI)

 10-N-0143:

A Prospective Natural History Study of Patients with Syringomyelia

 10-N-0122:

Evaluation, Pathogenesis, and Outcome of Subjects with or Suspected Traumatic Brain Injury

 10-N-0009:

Physiological Investigations of Movement Disorders

 09-N-0010:

Biomarkers of Risk of Parkinson Disease

 07-N-0190:

Neurobiological Studies of Functional Movement Disorders and Non-Epileptic Seizures

 07-N-0122:

Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

 04-N-0056:

The Neural Immune Mechanisms and Genetic Influences on Chronic Pelvic Pain in Women with Endometriosis

 00-N-0140:

A Prospective Natural History Study of VHL Patients with CNS Hemangioblastomas

 00-N-0089:

Genetic Analysis of the Chiari I Malformation

 93-N-0202:

Diagnosis and Natural History Protocol for Patients with Different Neurological Conditions