National Institute of Neurological Disorders and Stroke (NINDS)s

National Institute of Neurological Disorders and Stroke (NINDS)

95 Protocols (54 Active Accrual of new subjects, 41 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 001719-N:
Ultra-Low Field (ULF) Point Of Care (POC) MRI System for Study Brain Morphology and Pathology

* 001642-N:
ALLFTD: ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration

* 001519-N:
Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy: A Pilot Study

* 001505-N:
A Phase 1/2a, Randomized, Double-Blind, Placebo-Controlled, First In-Patient Study of AJ201 to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Adults With Spinal and Bulbar Muscular Atrophy (SBMA)

* 000865-N:
Natural History Protocol for Movement Disorders

* 000784-N:
Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects

* 000711-N:
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 (IN-PASC)

* 000642-N:
Phase II Trial of Non-Invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in Functional Movement Disorders

* 000625-N:
Investigational use of Neuromuscular Ultrasound

* 000560-N:
Data Collection of Standard Care of Patients in the EMG Section

* 000428-N:
An Observational Study to Assess Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)

* 000126-N:
A Pilot Study of NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients with Progressive Multifocal Leukoencephalopathy

* 000089-N:
Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health

* 000051-N:
NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

* 21-N-0016:
Phase I/II Study of Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

* 20-N-0105:
Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

* 20-N-0064:
An Observational Study to Assess Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing

* 20-N-0060:
Mechanisms Underlying the Beneficial Effects of Naps on Motor Learning

* 20-N-0019:
The Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing's Disease

* 18-N-0140:
Clinical Laboratory Evaluation of Chronic Autonomic Failure

* 18-N-0133:
Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery

* 18-N-0066:
Investigating Epilepsy: Screening and Evaluation

* 17-N-0168:
Influence of Brain Oscillation-Dependent TMS on Motor Function

* 17-N-0131:
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

* 16-N-0114:
The Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques: An Investigator-Blinded Study

* 16-N-0055:
The Pathological Basis of MRI Signal Changes in Multiple Sclerosis: A Longitudinal In Vivo-to-Postmortem Study

* 16-N-0041:
Tumor Related Epilepsy

* 16-N-0031:
An All-Night Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli

* 15-N-0177:
Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

* 15-N-0125:
Natural History Study of Inflammatory and Infectious Diseases of the Nervous System

* 15-N-0081:
A Study of Direct Brain Recording and Stimulation for Memory Enhancement

* 15-N-0073:
A Phase I Study of Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

* 14-N-0086:
Deep Brain Stimulation Therapy in Movement Disorders

* 14-N-0083:
Neural Basis of Decision Making Deficits in Traumatic Brain Injury

* 14-N-0061:
Noninvasive Pre-surgical Evaluation of Patients with Focal Epilepsy and Establishment of a Normative Imaging Database

* 13-N-0165:
Electrical Impedance Myography: Natural History Studies in Neuromuscular Disorders and Healthy Volunteers

* 13-N-0149:
An Evaluation of HIV-associated Neurocognitive Disorders (HAND) in Virologically Controlled Patients

* 13-N-0140:
Cerebrospinal Fluid Collection and Repository Storage

* 13-N-0017:
Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

* 12-N-0095:
Clinical and Molecular Manifestations of Neuromuscular and Neurogenetic Disorders of Childhood

* 11-N-0211:
Deep Brain Stimulation Surgery for Movement Disorders

* 11-N-0051:
Surgery as a Treatment for Medically Intractable Epilepsy

* 10-N-0012:
Screening Protocol for Patients with Stroke

* 09-N-0039:
A Phase I Study of the Intrathecal Administration of Resiniferatoxin for Treating Severe Refractory Pain Associated with Advanced Cancer

* 08-N-0044:
A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2).

* 03-N-0164:
Evaluation and Treatment of Neurosurgical Disorders

* 01-N-0206:
Phenotype/Genotype Correlations in Movement Disorders

* 01-N-0007:
Evaluation, Pathogenesis, and Treatment of Patients with or at Risk for Cerebrovascular Disease (A Natural History/Disease Pathogenesis Protocol)

* 00-N-0082:
Characterization of Brain Morphology and Activity Using Functional and Anatomical MRI Contrast

* 00-N-0043:
Clinical and Molecular Manifestations of Inherited Neurological Disorders

* 98-N-0047:
Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)

* 93-N-0202:
Diagnosis and Natural History Protocol for Patients with Different Neurological Conditions

* 89-N-0045:
Evaluation of Progression in Multiple Sclerosis by Magnetic Resonance Imaging (MRI)

* 85-N-0195:
Botulinum Toxin for the Treatment of Neurological Disorders

Active Follow-up, Protocols NOT Recruiting New Patients 

* 000196-N:
Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory

* 000094-N:
An Observational Study of Neurologic Function After COVID -19 Infection

* 21-N-0010:
A Phase 2 Clinical Trial of Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

* 20-N-0153:
Acute effects of medium chain triglyceride (MCT) nutritional ketosis on Parkinson's Disease (PD) symptoms and biomarkers (MCT-PD)

* 20-N-0077:
Study of Volition: Behavioral analysis and Clinical Neurophysiological Analysis

* 20-N-0048:
Corticotrophin-Releasing Hormone (CRH) Stimulation for 18F-FDG-PET Detection of Pituitary Adenoma in Cushing's Disease

* 19-N-0124:
Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

* 19-N-0081:
A Traveling Subject Study of Replicability in Conventional and Advanced MRI MS Biomarkers

* 19-N-0036:
Exploring the Relationship Between Brain Asymmetry and Attention

* 18-N-0083:
ASPIRO: A Phase 1/2/3, Randomized, Open-Label, Ascending-Dose, Delayed-Treatment Concurrent Control Clinical Study to Evaluate the Safety and Efficacy of AT132, an AAV8-Delivered Gene Therapy in X-Linked Myotubular Myopathy (XLMTM) Patients

* 18-N-0077:
Cytokine Microdialysis For Real Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade

* 18-N-0020:
The Natural History of Blood-Brain Barrier Disruption in Stroke Patients with White Matter Hyperintensities (A Cohort Study)

* 17-N-0145:
PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection

* 17-N-0035:
Clinical and Physiological Studies of Tremor Syndromes

* 16-N-0170:
Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation

* 16-N-0166:
Deep Brain Stimulation Surgery for Treatment of Focal Hand Dystonia

* 16-N-0072:
A Pilot Study of Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy with Ex Vivo Generated Polyomavirus-Specific T-cells

* 16-N-0064:
Cholinergic Receptor Imaging in Dystonia

* 16-N-0058:
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

* 15-N-0175:
An Open-Label, Phase 1b Safety and Efficacy Trial of Periganglionic Resiniferatoxin for the Treatment of Intractable Pain due to Cancer-induced Bone Pain

* 15-N-0167:
Propensity to Develop Plasticity in the Parieto-motor Network in Dystonia from the Perspective of Abnormal High-Order Motor Processing

* 15-N-0156:
In Vivo Characterization of Inflammation with Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging

* 15-N-0126:
HERV-K Suppression using Antiretroviral Therapy in Volunteers with Amyotrophic Lateral Sclerosis (ALS)

* 13-N-0188:
Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

* 13-N-0085:
Clinical Manifestations and Biorepository for Focal Dystonia

* 12-N-0137:
A Phase 1 Open-Label Dose Escalation Safety Study of Convection Enhanced Delivery (CED) of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor (AAV2-GDNF) in Subjects with Advanced Parkinson's Disease

* 12-N-0122:
Integrating Genetic and Environmental Risk Scores into an Algorithm to Predict Multiple Sclerosis Susceptibility

* 12-N-0083:
The Effectiveness of Botulinum Toxin on Persistent Pelvic Pain in Women with Endometriosis

* 12-N-0031:
Imaging Biomarkers in Parkinson Disease

* 11-N-0210:
NIB Repository Protocol

* 11-N-0084:
Evaluation and Diagnosis of Potential Research Subjects with Traumatic Brain Injury (TBI)

* 10-N-0143:
A Prospective Natural History Study of Patients with Syringomyelia

* 10-N-0122:
Evaluation, Pathogenesis, and Outcome of Subjects with or Suspected Traumatic Brain Injury

* 10-N-0009:
Physiological Investigations of Movement Disorders

* 09-N-0010:
Biomarkers of Risk of Parkinson Disease

* 07-N-0190:
Neurobiological Studies of Functional Movement Disorders and Non-Epileptic Seizures

* 07-N-0122:
Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

* 04-N-0056:
The Neural Immune Mechanisms and Genetic Influences on Chronic Pelvic Pain in Women with Endometriosis

* 02-N-0014:
Research Study of Specimens Obtained During Epilepsy Surgery

* 00-N-0140:
A Prospective Natural History Study of VHL Patients with CNS Hemangioblastomas

* 00-N-0089:
Genetic Analysis of the Chiari I Malformation