NIH Clinical Center Search the Studies: Study Number, Study Title

Protocol Details

An All-Night Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts




Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18
Max Age: 34

Referral Letter Required


Population Exclusion(s)

Non-English Speaking;

Special Instructions

Currently Not Provided


Functional Magnetic Resonance Imaging (fMRI);
Electroencephalogram (EEG)

Recruitment Keyword(s)



Normal Physiology

Investigational Drug(s)


Investigational Device(s)




Supporting Site

National Institute of Neurological Disorders and Stroke


An electroencephalogram (EEG) measures the brain s electrical activity. EEG shows that the louder the sound needed to wake a person, the deeper the person s sleep. Researchers are using functional magnetic resonance imaging (fMRI) to study people during sleep so they can view brain activity in 3D. But they still need to correlate fMRI with sound thresholds, like the EEG.


To measure brain activity during sleep using fMRI and EEG.


Healthy people ages 18 34 who can sleep on their back for several hours.


Participants will be screened online about their sleep and general health.

At a screening visit, participants will have:

Physical exam

Hearing exam

MRI scan. A strong magnetic field and radio waves take pictures of the brain. Participants will lie down on a bed that slides into the scanner, which is shaped like a cylinder.

Participants will wear an actigraph on their wrist that records their motor activity.

Participants will follow a 2-week routine. This includes regular in-to-bed and out-of-bed times and limits on alcohol, caffeine, and nicotine.

At the 3-day inpatient visit, participants will have:

Hearing exams.

Female subjects will have a urine pregnancy test.

fMRI. A coil will be placed over the head. Participants will do tasks shown on a computer screen inside the scanner.

EEG. Small electrodes on the scalp will record brain waves while sleeping or doing a task in the scanner.

Participants will be asked to try to sleep while researchers collect fMRI and EEG data. Participants eyes will be monitored with a video camera. Headphones will deliver sounds to wake them up throughout the night.

--Back to Top--



1. able to give informed consent;

2. in good general heath;

3. between the ages of 18 and 34 years;

4. able to sleep on your back for several hours (with breaks).


1. have a medical condition like diabetes or uncontrolled hypertension;

2. have a psychiatric or neurologic condition like depression or stroke;

3. have ever had a seizure;

4. have a sleep disorder like insomnia or sleep apnea;

5. work night shifts;

6. have metal in your body such as pacemakers, metal prostheses, or aneurysm clips that would make MRI scanning unsafe;

7. are pregnant or nursing;

8. drink too much caffeine (6 or more cups of coffee per day or 10 or more cups of caffeinated soda per day);

9. use too much alcohol (15 or more alcoholic beverages per week for men and 8 or more alcoholic beverages per week for women);

10. use too much nicotine (nicotine use within 30 minutes of waking);

11. are afraid of enclosed spaces;

12. have known hearing problems;

13. regularly use a prescription or over-the-counter drug to help you sleep or stay awake;

14. are an employee, contractor, or volunteer of the Laboratory of Functional and Molecular Imaging in the National Institute of Neurological Disorders and Stroke.

--Back to Top--


McWhirter KK, Morrow AS, Lee BA, Bishu S, Zametkin AJ, Balkin TJ, Smith CB, Picchioni D. A PILOT STUDY ON THE ENCODING OF A PERCEPTUAL LEARNING TASK FOLLOWING SLEEP DEPRIVATION. Percept Mot Skills. 2015 Aug;121(1):80-93. doi: 10.2466/23.PMS.121c11x9. Epub 2015 Jul 30. PubMed PMID: 26226287. 2: Picchioni D, Reith RM, Nadel JL, Smith CB. Sleep, plasticity and the pathophysiology of neurodevelopmental disorders: the potential roles of protein synthesis and other cellular processes. Brain Sci. 2014 Mar 1;4(1):150-201. doi: 10.3390/brainsci4010150. PubMed PMID: 24839550; PubMed Central PMCID: PMC4020186. 3: Messina G, Damia E, Fanti L, Atterrato MT, Celauro E, Mariotti FR, Accardo MC, Walther M, Vern(SqrRoot) F, Picchioni D, Moschetti R, Caizzi R, Piacentini L, Cenci G, Giordano E, Dimitri P. Yeti, an essential Drosophila melanogaster gene, encodes a protein required for chromatin organization. J Cell Sci. 2014 Jun 1;127(Pt 11):2577-88. doi: 10.1242/jcs.150243. Epub 2014 Mar 20. PubMed PMID: 24652835. 4: Picchioni D, Pixa ML, Fukunaga M, Carr WS, Horovitz SG, Braun AR, Duyn JH. Decreased connectivity between the thalamus and the neocortex during human nonrapid eye movement sleep. Sleep. 2014 Feb 1;37(2):387-97. doi: 10.5665/sleep.3422. PubMed PMID: 24497667; PubMed Central PMCID: PMC3900615. 5: Newman RA, Kamimori GH, Wesensten NJ, Picchioni D, Balkin TJ. Caffeine gum minimizes sleep inertia. Percept Mot Skills. 2013 Feb;116(1):280-93. PubMed PMID: 23829154. 6: Khan S, Garg A, Sharma A, Camacho N, Picchioni D, Saint-L(SqrRoot)(Copyright)ger A, Ribas de Pouplana L, Yogavel M, Sharma A. An appended domain results in an unusual architecture for malaria parasite tryptophanyl-tRNA synthetase. PLoS One. 2013 Jun 12;8(6):e66224. doi: 10.1371/journal.pone.0066224. Print 2013. PubMed PMID: 23776638; PubMed Central PMCID: PMC3680381. 7: Chow HM, Horovitz SG, Carr WS, Picchioni D, Coddington N, Fukunaga M, Xu Y, Balkin TJ, Duyn JH, Braun AR. Rhythmic alternating patterns of brain activity distinguish rapid eye movement sleep from other states of consciousness. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10300-5. doi: 10.1073/pnas.1217691110. Epub 2013 Jun 3. Erratum in: Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13228. PubMed PMID: 23733938; PubMed Central PMCID: PMC3690889. 8: Picchioni D, Duyn JH, Horovitz SG. Sleep and the functional connectome. Neuroimage. 2013 Oct 15;80:387-96. doi: 10.1016/j.neuroimage.2013.05.067. Epub 2013 May 24.

Watanabe T, Kan S, Koike T, Misaki M, Konishi S, Miyauchi S, Miyahsita Y, Masuda N. Network-dependent modulation of brain activity during sleep. Neuroimage. 2014 Sep;98:1-10. doi: 10.1016/j.neuroimage.2014.04.079. Epub 2014 May 9.

Ogilvie RD, Wilkinson RT, Allison S. The detection of sleep onset: behavioral, physiological, and subjective convergence. Sleep. 1989 Oct;12(5):458-74.

--Back to Top--


Principal Investigator

Referral Contact

For more information:

Jeffrey H. Duyn, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)

Susan Fulton Guttman
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
Building 10
Room B1D704A
10 Center Drive
Bethesda, Maryland 20892
(301) 451-9912

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010

Clinical Trials Number:


--Back to Top--