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Protocol Details

NIB Repository Protocol

This study is NOT currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

11-N-0210

Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Completed Study; data analyses ongoing
Gender: Male & Female
Min Age: N/A
Max Age: N/A

Referral Letter Required

Yes

Population Exclusion(s)

None

Special Instructions

Currently Not Provided

Keywords

Storage;
Repository;
Samples;
Data

Recruitment Keyword(s)

Data;
Samples

Condition(s)

HTLV-1 Infection;
Multiple Sclerosis;
Neurologic Disorders

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Neurological Disorders and Stroke

Background:

- Information and samples collected from participants in medical research studies can be useful even after the original study is complete. Researchers can use the information and samples to learn more about multiple sclerosis or other immune system disorders. They can also be used for research into other disorders. Researchers would like to get permission to use samples collected from older studies to launch new lines of research.

Objectives:

- To look at information and samples from earlier National Institutes of Health Neuroimmunology Branch studies.

Eligibility:

- People who provided samples and medical information for earlier studies.

Design:

- Researchers will contact people who took part in earlier studies. Researchers will ask if they can study previously collected data and samples.

- Data and samples may include physical exam data and psychological test results. Imaging study results are included. Preserved samples of body fluids and tissues may be studied. These include blood and urine samples.

- No new treatment will be provided as part of this research study.

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Eligibility

Subjects who previously participated in NIH protocols for whom we have samples or data whose wishes regarding use of their samples/data for research other than that specified in the initial protocol is not known, or where we would like to use their samples or data for purposes other than those they have consented for may be enrolled in this protocol if they are able to be contacted and consent to additional use of their samples or data.

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Citations:

Bielekova B, Richert N, Howard T, Packer AN, Blevins G, Ohayon J, McFarland HF, St(SqrRoot) rzebecher CS, Martin R. Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood brain barrier disruption in multiple sclerosis. Mult Scler. 2009 Oct;15(10):1206-14. Epub 2009 Sep 23.

Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, Afshar G, Gran B, Eaton J, Antel J, Frank JA, McFarland HF, Martin R. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med. 2000 Oct;6(10):1167-75. Erratum in: Nat Med 2000 Dec;6(12):1412.

Bielekova B, Martin R. Antigen-specific immunomodulation via altered peptide ligands. J Mol Med. 2001 Oct;79(10):552-65.

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Contacts:

Principal Investigator

Referral Contact

For more information:

Avindra Nath, M.D.
National Institute of Neurological Disorders and Stroke (NINDS)
BG 10 RM 7C103
10 CENTER DR
BETHESDA MD 20814
(301) 496-1561
natha@mail.nih.gov

Joan M. Ohayon, C.R.N.P.
National Institute of Neurological Disorders and Stroke (NINDS)
BG 10 RM 5C442
10 CENTER DR
BETHESDA MD 20814
(301) 496-3825
eatonj@ninds.nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010
PRPL@cc.nih.gov

Clinical Trials Number:

NCT01581567

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