NIH Clinical Center: Search the Studies

Search the Studies

94 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.

Protocol Number	Title	Protocol Status	Min-Max Age	Institute	Keywords
20-EI-0163	Oral Metformin for Treatment of ABCA4 Retinopathy	Participants currently recruited/enrolled	12-125 Years	NEI	Retinal Degeneration
20-EI-0052	A Phase I/IIa Trial for Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated with Age-Related Macular Degeneration	Participants currently recruited/enrolled	55-125 Years	NEI	Retinal Degeneration
20-EI-0026	An Observational Cross-Sectional Study of Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease	Participants currently recruited/enrolled	5-125 Years	NEI	Retinal Degeneration
18-EI-0068	An Investigation of Vitamin A Palmitate Supplementation in Patients with Reticular Pseudodrusen (RPD) and Delayed Dark Adaptation	Participants currently recruited/enrolled	50-125 Years	NEI	Retinal Degeneration
18-EI-0067	An Investigation of Vitamin A Palmitate Supplementation in Patients with Age-Related Macular Degeneration (and without reticular pseudodrusen) and Delayed Dark Adaptation	Participants currently recruited/enrolled	50-125 Years	NEI	Retinal Degeneration
16-EI-0024	Rod and Cone Mediated Function in Retinal Disease	Participants currently recruited/enrolled	5-125 Years	NEI	Retinal Degeneration
14-EI-0171	The Focal Electro-Oculogram in Macular Disease	Completed Study; data analyses ongoing	10-125 Years	NEI	Retinal Degeneration
12-EI-0203	Natural History of ABCA4-Related Retinopathies	No longer recruiting/follow-up only	12-125 Years	NEI	Retinal Degeneration
12-EI-0042	NEI Intramural Biorepository for Retinal Diseases	Participants currently recruited/enrolled	2-125 Years	NEI	Retinal Degeneration
11-EI-0245	Generation of Induced Pluripotent Stem (iPS) Cell Lines from Somatic Cells of Participants with Eye Diseases and from Somatic Cells of Matched Controls	Participants currently recruited/enrolled	1-125 Years	NEI	Retinal Degeneration
06-EI-0236	National Ophthalmic Genotyping and Phenotyping Network Stage 1 - Creation of DNA Repository for Inherited Ophthalmic Diseases	No longer recruiting/follow-up only	2-125 Years	NEI	Retinal Degeneration
000908-DK	Peripheral Blood and Urine Immune Cell Phenotyping in Membranous Nephropathy using FACS and Single Cell RNA-seq	Participants currently recruited/enrolled	18-125 Years	NIDDK	Peripheral
000633-C	Phase 1/2 Study of VIP152, Venetoclax, and Prednisone (VVIP) in Relapsed/Refractory Lymphoid Malignancies	Participants currently recruited/enrolled	18-125 Years	NCI	Peripheral
000625-N	Investigational use of Neuromuscular Ultrasound	Participants currently recruited/enrolled	18-125 Years	NINDS	Peripheral
000613-C	Phase I/II Trial to Determine the Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination with Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis after Reduced Intensity Conditioning and Peripheral Blood St	Participants currently recruited/enrolled	12-125 Years	NCI	Peripheral
000585-CH	An Open-label Safety, Pharmacokinetic, and Efficacy Study of Miglustat for the Treatment of CLN3 Disease in Patients 17 Years of Age and Older	Participants currently recruited/enrolled	17-125 Years	NICHD	Retinal
000473-C	A Randomized Phase II Study of Systemic Chemotherapy with or without HAI FUDR-Dexamethasone in Patients with Unresectable Intrahepatic Cholangiocarcinoma	Participants currently recruited/enrolled	18-125 Years	NCI	Peripheral
000413-H	Natural History study of CADASIL	Participants currently recruited/enrolled	18-100 Years	NHLBI	Degeneration
000317-C	A Phase II, Open-Label Trial of PT-112 in Subjects with Thymoma and Thymic Carcinoma	Participants currently recruited/enrolled	18-125 Years	NCI	Peripheral
000187-EI	Adaptive Optics Imaging of Outer Retinal Diseases	Participants currently recruited/enrolled	21-125 Years	NEI	Retinal
21-C-0015	Phase II Trial Evaluating the Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment with Immune Checkpoint Inhibition (ICI) in Patients with Newly Diagnosed Glioblastoma or Gliosarcoma	Participants currently recruited/enrolled	18-125 Years	NCI	Peripheral
20-M-0157	PET Imaging of Cyclooxygenase in Participants with Major Depressive Disorder (MDD)	Participants currently recruited/enrolled	18-70 Years	NIMH	Peripheral
20-H-0137	A Study to Evaluate the Effects of Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects with Stable Sickle Cell Disease	Completed Study; data analyses ongoing	18-46 Years	NHLBI	Peripheral
20-C-0127	A Phase 1 Study of Romidepsin, CC-486 (5-azacitidine), dexamethasone, and lenalidomide (RAdR) for relapsed/refractory T-cell malignancies	Participants currently recruited/enrolled	18-125 Years	NCI	Peripheral
20-C-0121	Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel	Participants currently recruited/enrolled	18-125 Years	NCI	Peripheral
20-C-0041	Protocol for a Research Database for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries	Enrolling by Invitation	1-125 Years	NCI	Peripheral
20-C-0023	First-in-Human Phase I Trial to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of Metarrestin (ML-246) in Subjects with Metastatic Solid Tumors	Participants currently recruited/enrolled	12-125 Years	NCI	Peripheral
19-I-0080	Haploidentical Transplant for Patients with Chronic Granulomatous Disease (CGD) using Alemtuzumab, Busulfan and TBI with Post-Transplant Cyclophosphamide	Participants currently recruited/enrolled	4-65 Years	NIAID	Peripheral
19-H-0118	Repeat Peripheral Blood Stem Cell Transplantation for Patients with Sickle Cell Disease or Beta-Thalassemia and Falling Donor Myeloid Chimerism Levels	Participants currently recruited/enrolled	2-80 Years	NHLBI	Peripheral
19-C-0134	A Phase 1/1b Study of Enhancement of Immune Reconstitution and Vaccine Responses with Administration of Recombinant Human IL-7-hyFc (NT-I7) in Older Subjects Following Chemotherapy	Participants currently recruited/enrolled	60-125 Years	NCI	Peripheral
19-C-0085	Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Peripheral T cell Lymphoma	Clinical hold/Recruitment or enrollment suspended	12-125 Years	NCI	Peripheral
19-C-0076	A Phase 1 Study of Interleukin-15 in Combination with Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell Malignancies	Completed Study; data analyses ongoing	18-125 Years	NCI	Peripheral
19-C-0061	A Phase 2 Trial of the MEK Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Combination with the mTOR Inhibitor Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors	Participants currently recruited/enrolled	12-125 Years	NCI	Peripheral
19-C-0017	A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients	Participants currently recruited/enrolled	18-70 Years	NCI	Peripheral
19-C-0016	Natural History and Biospecimen Acquisition Study for Children and Adults with Rare Solid Tumors	Participants currently recruited/enrolled	0-125 Years	NCI	Peripheral
18-H-0090	Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH using Peripheral Blood Stem Cells and post-transplant Cyclophosphamide for GVHD prophylaxis	Participants currently recruited/enrolled	4-75 Years	NHLBI	Peripheral
17-H-0124	Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patients Using Plerixafor	Completed Study; data analyses ongoing	18-125 Years	NHLBI	Peripheral
17-H-0069	Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease	Participants currently recruited/enrolled	2-125 Years	NHLBI	Peripheral
17-EI-0112	A Long-term Follow-up Study of Participants Enrolled in 11-EI-0147: Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration (DA_AMD)	Participants currently recruited/enrolled	50-125 Years	NEI	Degeneration
17-EI-0071	AMD Ryan Initiative Study	Completed Study; data analyses ongoing	55-125 Years	NEI	Degeneration
17-EI-0008	The Natural History of Geographic Atrophy Associated with Age-Related Macular Degeneration	Participants currently recruited/enrolled	55-125 Years	NEI	Degeneration
17-C-0113	A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients	Participants currently recruited/enrolled	18-70 Years	NCI	Peripheral
17-C-0048	Anti-CD30 CAR T Cells with Fully-human Binding Domains for Treating CD30-expressing Lymphomas Including Anaplastic Large Cell Lymphomas	Completed Study; data analyses ongoing	18-73 Years	NCI	Peripheral
16-I-0032	High Dose Peripheral Blood Stem Cell Transplantation with Post Transplant Cyclophosphamide for Patients with Chronic Granulomatous Disease	No longer recruiting/follow-up only	4-65 Years	NIAID	Peripheral
16-H-0132	CADASIL Disease Discovery	Completed Study; data analyses ongoing	18-100 Years	NHLBI	Degeneration
16-C-0138	Collection of Peripheral Blood Mononuclear Cells (PBMCs) from Healthy Subjects for the Expansion of T Cells for Adoptive Cell Therapy	Participants currently recruited/enrolled	18-99 Years	NCI	Peripheral
16-C-0135	A Pilot Study of Combined Immune Checkpoint Inhibition in combination with Ablative Therapies in Subjects with Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)	No longer recruiting/follow-up only	18-125 Years	NCI	Peripheral
16-C-0131	A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a CD70-Binding Chimeric Antigen Receptor to Patients with CD70-Expressing Cancers	Participants currently recruited/enrolled	18-70 Years	NCI	Peripheral
16-C-0062	A Phase I Study of Subcutaneous Recombinant Human IL-15 (S.C. Rhil-15) and Alemtuzumab for Patients with Refractory or Relapsed Chronic and Acute Adult T-Cell Leukemia (ATL)	Completed Study; data analyses ongoing	18-125 Years	NCI	Peripheral
15-H-0016	A Phase II Study Using ACP-196 in Patients with Relapsed/Refractory and Treatment Naive Deletion 17p CLL/SLL: Pharmacodynamic Assessment of BTK Inhibition and Anti-Tumor Response.	No longer recruiting/follow-up only	18-125 Years	NHLBI	Peripheral
15-EI-0202	Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated with Age-Related Macular Degeneration	No longer recruiting/follow-up only	55-125 Years	NEI	Degeneration
15-EI-0038	A Phase I/IIa Study of RS1 Ocular Gene Transfer for X-linked Retinoschisis	No longer recruiting/follow-up only	18-125 Years	NEI	Retinal
15-EI-0020	Adaptive Optics Retinal Imaging	Participants currently recruited/enrolled	12-125 Years	NEI	Retinal
15-C-0078	Safety and Feasibility of Stem Cell Gene Transfer Following R-EPOCH for Non-Hodgkin Lymphoma in AIDS Patients Using Peripheral Blood Stem/Progenitor Cells Treated with a Lentivirus Vector-Encoding Multiple Anti-HIV RNAs	No longer recruiting/follow-up only	18-65 Years	NCI	Peripheral
15-AR-0060	The Role of PPAR-gamma Agonists in immunomodulation and Vascular Prevention in SLE (PPAR-SLE)	Completed Study; data analyses ongoing	18-99 Years	NIAMS	Peripheral
14-I-0020	Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models	Participants currently recruited/enrolled	18-65 Years	NIAID	Peripheral
14-HG-0048	Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)	Participants currently recruited/enrolled	21-125 Years	NHGRI	Peripheral
14-H-0077	Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia in Individuals with Higher Risk of Transplant Failure	Participants currently recruited/enrolled	4-125 Years	NHLBI	Peripheral
14-C-0163	Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1: Clinical, Histopathologic, and Genomic Analysis	Completed Study; data analyses ongoing	10-125 Years	NCI	Peripheral
13-N-0188	Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia	Completed Study; data analyses ongoing	18-125 Years	NINDS	Degeneration
13-EI-0049	Pathogenesis and Genetics of Microphthalmia, Anophthalmia and Uveal Coloboma ( MAC)	Participants currently recruited/enrolled	1-125 Years	NEI	Retinal
13-C-0132	Allogeneic Hematopoietic Stem Cell Transplant for Patients with Mutations in GATA2 or the MonoMAC Syndrome	Participants currently recruited/enrolled	8-70 Years	NCI	Peripheral
11-I-0007	Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age with X-Linked Severe Combined Immunodeficiency	Clinical hold/Recruitment or enrollment suspended	2-40 Years	NIAID	Peripheral
11-EI-0264	A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Central Retinal Vein Occlusions	Completed Study; data analyses ongoing	18-125 Years	NEI	Retinal
11-EI-0263	A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Branch Retinal Vein Occlusions	Completed Study; data analyses ongoing	18-125 Years	NEI	Retinal
11-EI-0147	Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration	Participants currently recruited/enrolled	50-125 Years	NEI	Degeneration
10-EI-0140	Genotype - phenotype Study of Patients with Plaquenil-induced Retinal Toxicity	Participants currently recruited/enrolled	18-125 Years	NEI	Retinal
10-DK-N091	Molecular and Clinical Profile of Diabetes Mellitus and its Complications	Participants currently recruited/enrolled	18-125 Years	NIDDK	Retinal
10-C-0201	Apheresis and CD34+ Selection of Mobilized Peripheral Blood CD34+ Cells from Patients with DOCK8 Deficiency, LAD-1, and GATA2 Deficiency	Participants currently recruited/enrolled	18-40 Years	NCI	Peripheral
09-H-0225	Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-Thalassemia	No longer recruiting/follow-up only	2-125 Years	NHLBI	Peripheral
08-N-0044	A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2).	Participants currently recruited/enrolled	8-75 Years	NINDS	Peripheral
08-H-0046	Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy	Completed Study; data analyses ongoing	4-75 Years	NHLBI	Peripheral
08-EI-0102	Screening Protocol for the Evaluation and Diagnosis of Potential Research Participants	Participants currently recruited/enrolled	2-125 Years	NEI	Retinal
08-EI-0043	Age-Related Eye Disease Study (AREDS) and AREDS2 Follow-Up	No longer recruiting/follow-up only	50-125 Years	NEI	Degeneration
08-C-0130	A Phase II Trial of Peginterferon alfa-2b (PEG-Intron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform Neurofibromas	Completed Study; data analyses ongoing	0-21 Years	NCI	Peripheral
08-C-0079	Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromatosis Type 1	No longer recruiting/follow-up only	0-125 Years	NCI	Peripheral
07-N-0122	Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System	Completed Study; data analyses ongoing	18-125 Years	NINDS	Peripheral
05-H-0130	Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell Transplants	Participants currently recruited/enrolled	7-80 Years	NHLBI	Peripheral
04-C-0238	A Phase 2 Study of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Von Hippel Lindau Disease and Renal Tumors	Completed Study; data analyses ongoing	18-125 Years	NCI	Retinal
03-H-0170	Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-Thalassemia	Participants currently recruited/enrolled	2-125 Years	NHLBI	Peripheral
03-EI-0033	X-Linked Juvenile Retinoschisis - Clinical and Molecular Studies	Participants currently recruited/enrolled	0-125 Years	NEI	Degeneration
02-I-0286	Efficacy of Tyrosine Kinase Inhibition in Reducing Eosinophilia in Patients with Myeloid and/or Steroid-Refractory Hypereosinophilic Syndrome	Participants currently recruited/enrolled	2-125 Years	NIAID	Peripheral
02-H-0250	A Phase I/II Study of HLA-matched Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation for Advanced Mycosis Fungoides/Sezary Syndrome Using Nonmyeloablative Conditioning with Campath-1H	Completed Study; data analyses ongoing	18-125 Years	NHLBI	Peripheral
02-C-0064	Collection of Peripheral Blood and/or Urine From Patients Undergoing Radiation Therapy	Enrolling by Invitation	18-125 Years	NCI	Peripheral
00-N-0043	Clinical and Molecular Manifestations of Inherited Neurological Disorders	Participants currently recruited/enrolled	2-125 Years	NINDS	Peripheral
99-H-0050	Non-Myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in High Risk Patients and in Patients with Debilitating Hematologic Diseases	Completed Study; data analyses ongoing	2-80 Years	NHLBI	Peripheral
96-H-0049	Use of Granulocyte Colony Stimulating Factor (G-CSF) Mobilized Leukapheresis Collections from Healthy Volunteers to Develop Improved Methods of Stem Cell and Lymphocyte Selection for Allogeneic Transplantation	Participants currently recruited/enrolled	18-60 Years	NHLBI	Peripheral
94-I-0079	Eosinophil Activation and Function in Parasitic Infections and Other Conditions with Increased Tissue or Peripheral Blood Eosinophilia in Humans	Participants currently recruited/enrolled	1-100 Years	NIAID	Peripheral
94-I-0073	Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and Granulocytes	Participants currently recruited/enrolled	18-70 Years	NIAID	Peripheral
94-HG-0105	An Exploratory Study of the Genetics, Pathophysiology, and Natural History of Autoinflammatory Diseases	Participants currently recruited/enrolled	0-125 Years	NHGRI	Retinal
93-I-0063	Study of the Immunopathogenesis, Natural History, and Genetics of Autoimmune Lymphoproliferative Syndrome (ALPS) Associated with an Expansion of CD4-8-/TCR alpha/beta+ T Cells	Participants currently recruited/enrolled	0-99 Years	NIAID	Peripheral
92-I-0125	A Study of Viral Burden in Peripheral Blood Versus Lymphoid and Bone Marrow Tissue in HIV-Infected Individuals	Participants currently recruited/enrolled	18-125 Years	NIAID	Peripheral
91-I-0140	Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in HIV-Infected and HIV-Uninfected Volunteers	Participants currently recruited/enrolled	18-125 Years	NIAID	Peripheral
91-AR-0196	Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases	Participants currently recruited/enrolled	16-125 Years	NIAMS	Degeneration