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95 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.
Protocol Number Title Protocol Status Min-Max Age Institute Keywords
20-EI-0163Oral Metformin for Treatment of ABCA4 RetinopathyParticipants currently recruited/enrolled12-100 YearsNEI Retinal Degeneration
20-EI-0052A Phase I/IIa Trial for Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated with Age-Related Macular DegenerationParticipants currently recruited/enrolled55-125 YearsNEI Retinal Degeneration
20-EI-0026An Observational Cross-Sectional Study of Virtual Reality Mobility Assessment of Functional Vision in Retinal DiseaseParticipants currently recruited/enrolled5-125 YearsNEI Retinal Degeneration
18-EI-0068An Investigation of Vitamin A Palmitate Supplementation in Patients with Reticular Pseudodrusen (RPD) and Delayed Dark AdaptationParticipants currently recruited/enrolled50-125 YearsNEI Retinal Degeneration
18-EI-0067An Investigation of Vitamin A Palmitate Supplementation in Patients with Age-Related Macular Degeneration (and without reticular pseudodrusen) and Delayed Dark AdaptationParticipants currently recruited/enrolled50-125 YearsNEI Retinal Degeneration
16-EI-0024Rod and Cone Mediated Function in Retinal DiseaseParticipants currently recruited/enrolled5-100 YearsNEI Retinal Degeneration
14-EI-0171The Focal Electro-Oculogram in Macular DiseaseCompleted Study; data analyses ongoing10-100 YearsNEI Retinal Degeneration
12-EI-0203Natural History of ABCA4-Related RetinopathiesNo longer recruiting/follow-up only12-100 YearsNEI Retinal Degeneration
12-EI-0042NEI Intramural Biorepository for Retinal DiseasesParticipants currently recruited/enrolled2-125 YearsNEI Retinal Degeneration
11-EI-0245Generation of Induced Pluripotent Stem (iPS) Cell Lines from Somatic Cells of Participants with Eye Diseases and from Somatic Cells of Matched ControlsParticipants currently recruited/enrolled0-120 YearsNEI Retinal Degeneration
06-EI-0236National Ophthalmic Genotyping and Phenotyping Network Stage 1 - Creation of DNA Repository for Inherited Ophthalmic DiseasesNo longer recruiting/follow-up only2-125 YearsNEI Retinal Degeneration
001678-ATMicroneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals with Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 GeneRecruitment has not started18-100 YearsNCCIHPeripheral
001642-NALLFTD: ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar DegenerationParticipants currently recruited/enrolled18-99 YearsNINDSDegeneration
001549-CPhase II Evaluation of Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent in Subjects with BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage MesotheliomaRecruitment has not started18-120 YearsNCI Peripheral
001544-CPhase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG with Entinostat and Nivolumab as Adjuvant Therapy following Chemoradiation Therapy with or without Surgery for Locally Advanced Esophageal CancerRecruitment has not started18-120 YearsNCI Peripheral
000908-DKPeripheral Blood and Urine Immune Cell Phenotyping in Membranous Nephropathy using FACS and Single Cell RNA-seqParticipants currently recruited/enrolled18-125 YearsNIDDKPeripheral
000633-CPhase 1/2 Study of VIP152, Venetoclax, and Prednisone (VVIP) in Relapsed/Refractory Lymphoid MalignanciesParticipants currently recruited/enrolled18-125 YearsNCI Peripheral
000625-NInvestigational use of Neuromuscular UltrasoundParticipants currently recruited/enrolled18-110 YearsNINDSPeripheral
000613-CPhase I/II Trial to Determine the Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination with Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis after Reduced Intensity Conditioning and Peripheral Blood StParticipants currently recruited/enrolled12-125 YearsNCI Peripheral
000585-CHAn Open-label Safety, Pharmacokinetic, and Efficacy Study of Miglustat for the Treatment of CLN3 Disease in Patients 17 Years of Age and OlderParticipants currently recruited/enrolled17-125 YearsNICHDRetinal
000473-CA Randomized Phase II Study of Systemic Chemotherapy with or without HAI FUDR-Dexamethasone in Patients with Unresectable Intrahepatic CholangiocarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Peripheral
000413-HNatural History study of CADASILParticipants currently recruited/enrolled18-100 YearsNHLBIDegeneration
000317-CA Phase II, Open-Label Trial of PT-112 in Subjects with Thymoma and Thymic CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Peripheral
000187-EIAdaptive Optics Imaging of Outer Retinal DiseasesParticipants currently recruited/enrolled21-125 YearsNEI Retinal
21-C-0015Phase II Trial Evaluating the Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment with Immune Checkpoint Inhibition (ICI) in Patients with Newly Diagnosed Glioblastoma or GliosarcomaParticipants currently recruited/enrolled18-125 YearsNCI Peripheral
20-C-0127A Phase 1 Study of Romidepsin, CC-486 (5-azacitidine), dexamethasone, and lenalidomide (RAdR) for relapsed/refractory T-cell malignanciesParticipants currently recruited/enrolled18-125 YearsNCI Peripheral
20-C-0121Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and PaclitaxelParticipants currently recruited/enrolled18-125 YearsNCI Peripheral
20-C-0041Protocol for a Research Database for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic InjuriesEnrolling by Invitation1-125 YearsNCI Peripheral
20-C-0023First-in-Human Phase I Trial to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of Metarrestin (ML-246) in Subjects with Metastatic Solid TumorsParticipants currently recruited/enrolled12-125 YearsNCI Peripheral
19-I-0080Haploidentical Transplant for Patients with Chronic Granulomatous Disease (CGD) using Alemtuzumab, Busulfan and TBI with Post-Transplant CyclophosphamideParticipants currently recruited/enrolled4-65 YearsNIAIDPeripheral
19-H-0118Repeat Peripheral Blood Stem Cell Transplantation for Patients with Sickle Cell Disease or Beta-Thalassemia and Falling Donor Myeloid Chimerism LevelsParticipants currently recruited/enrolled2-80 YearsNHLBIPeripheral
19-C-0085Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Peripheral T cell LymphomaClinical hold/Recruitment or enrollment suspended12-125 YearsNCI Peripheral
19-C-0076A Phase 1 Study of Interleukin-15 in Combination with Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell MalignanciesCompleted Study; data analyses ongoing18-125 YearsNCI Peripheral
19-C-0061A Phase 2 Trial of the MEK Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Combination with the mTOR Inhibitor Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath TumorsParticipants currently recruited/enrolled12-125 YearsNCI Peripheral
19-C-0046Long-Term Follow-up Protocol for Subjects Treated with Gene-Modified T cells.No longer recruiting/follow-up only18-125 YearsNCI Peripheral
19-C-0017A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 PatientsParticipants currently recruited/enrolled18-72 YearsNCI Peripheral
19-C-0016Natural History and Biospecimen Acquisition Study for Children and Adults with Rare Solid TumorsParticipants currently recruited/enrolled0-125 YearsNCI Peripheral
18-H-0090Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH using Peripheral Blood Stem Cells and post-transplant Cyclophosphamide for GVHD prophylaxisParticipants currently recruited/enrolled4-75 YearsNHLBIPeripheral
17-H-0124Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patients Using PlerixaforCompleted Study; data analyses ongoing18-125 YearsNHLBIPeripheral
17-H-0069Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseNo longer recruiting/follow-up only2-100 YearsNHLBIPeripheral
17-EI-0112A Long-term Follow-up Study of Participants Enrolled in 11-EI-0147: Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration (DA_AMD)Participants currently recruited/enrolled50-125 YearsNEI Degeneration
17-EI-0071AMD Ryan Initiative StudyCompleted Study; data analyses ongoing55-125 YearsNEI Degeneration
17-EI-0008The Natural History of Geographic Atrophy Associated with Age-Related Macular DegenerationParticipants currently recruited/enrolled55-120 YearsNEI Degeneration
17-C-0113A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 PatientsParticipants currently recruited/enrolled18-72 YearsNCI Peripheral
17-C-0048Anti-CD30 CAR T Cells with Fully-human Binding Domains for Treating CD30-expressing Lymphomas Including Anaplastic Large Cell LymphomasCompleted Study; data analyses ongoing18-73 YearsNCI Peripheral
16-I-0032High Dose Peripheral Blood Stem Cell Transplantation with Post Transplant Cyclophosphamide for Patients with Chronic Granulomatous DiseaseNo longer recruiting/follow-up only4-65 YearsNIAIDPeripheral
16-H-0132CADASIL Disease DiscoveryCompleted Study; data analyses ongoing18-100 YearsNHLBIDegeneration
16-C-0138Collection of Peripheral Blood Mononuclear Cells (PBMCs) from Healthy Subjects for the Expansion of T Cells for Adoptive Cell TherapyParticipants currently recruited/enrolled18-120 YearsNCI Peripheral
16-C-0135A Pilot Study of Combined Immune Checkpoint Inhibition in combination with Ablative Therapies in Subjects with Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)Completed Study; data analyses ongoing18-125 YearsNCI Peripheral
16-C-0131A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a CD70-Binding Chimeric Antigen Receptor to Patients with CD70-Expressing CancersParticipants currently recruited/enrolled18-72 YearsNCI Peripheral
15-H-0016A Phase II Study Using ACP-196 in Patients with Relapsed/Refractory and Treatment Naive Deletion 17p CLL/SLL: Pharmacodynamic Assessment of BTK Inhibition and Anti-Tumor Response.No longer recruiting/follow-up only18-125 YearsNHLBIPeripheral
15-EI-0202Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated with Age-Related Macular DegenerationCompleted Study; data analyses ongoing55-100 YearsNEI Degeneration
15-EI-0038A Phase I/IIa Study of RS1 Ocular Gene Transfer for X-linked RetinoschisisNo longer recruiting/follow-up only18-125 YearsNEI Retinal
15-EI-0020Adaptive Optics Retinal ImagingParticipants currently recruited/enrolled12-125 YearsNEI Retinal
15-C-0078Safety and Feasibility of Stem Cell Gene Transfer Following R-EPOCH for Non-Hodgkin Lymphoma in AIDS Patients Using Peripheral Blood Stem/Progenitor Cells Treated with a Lentivirus Vector-Encoding Multiple Anti-HIV RNAsNo longer recruiting/follow-up only18-65 YearsNCI Peripheral
15-AR-0060The Role of PPAR-gamma Agonists in immunomodulation and Vascular Prevention in SLE (PPAR-SLE)Completed Study; data analyses ongoing18-99 YearsNIAMSPeripheral
14-I-0020Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine ModelsParticipants currently recruited/enrolled18-65 YearsNIAIDPeripheral
14-HG-0048Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)No longer recruiting/follow-up only21-125 YearsNHGRIPeripheral
14-H-0077Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia in Individuals with Higher Risk of Transplant FailureParticipants currently recruited/enrolled4-80 YearsNHLBIPeripheral
14-C-0163Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1: Clinical, Histopathologic, and Genomic AnalysisCompleted Study; data analyses ongoing10-125 YearsNCI Peripheral
13-N-0188Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal DementiaCompleted Study; data analyses ongoing18-125 YearsNINDSDegeneration
13-EI-0049Pathogenesis and Genetics of Microphthalmia, Anophthalmia and Uveal Coloboma ( MAC)Participants currently recruited/enrolled1-125 YearsNEI Retinal
13-C-0132Allogeneic Hematopoietic Stem Cell Transplant for Patients with Mutations in GATA2 or the MonoMAC SyndromeParticipants currently recruited/enrolled8-70 YearsNCI Peripheral
11-I-0007Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age with X-Linked Severe Combined ImmunodeficiencyClinical hold/Recruitment or enrollment suspended2-40 YearsNIAIDPeripheral
11-EI-0264A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Central Retinal Vein OcclusionsCompleted Study; data analyses ongoing18-125 YearsNEI Retinal
11-EI-0263A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Branch Retinal Vein OcclusionsCompleted Study; data analyses ongoing18-125 YearsNEI Retinal
11-EI-0147Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular DegenerationParticipants currently recruited/enrolled50-125 YearsNEI Degeneration
10-EI-0140Genotype - phenotype Study of Patients with Plaquenil-induced Retinal ToxicityParticipants currently recruited/enrolled18-125 YearsNEI Retinal
10-DK-N091Molecular and Clinical Profile of Diabetes Mellitus and its ComplicationsParticipants currently recruited/enrolled18-125 YearsNIDDKRetinal
10-C-0201Apheresis and CD34+ Selection of Mobilized Peripheral Blood CD34+ Cells from Patients with DOCK8 Deficiency, LAD-1, and GATA2 DeficiencyParticipants currently recruited/enrolled18-40 YearsNCI Peripheral
09-H-0225Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-ThalassemiaNo longer recruiting/follow-up only2-100 YearsNHLBIPeripheral
08-N-0044A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2).Participants currently recruited/enrolled8-75 YearsNINDSPeripheral
08-H-0046Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive TherapyCompleted Study; data analyses ongoing4-75 YearsNHLBIPeripheral
08-EI-0102Screening Protocol for the Evaluation and Diagnosis of Potential Research ParticipantsParticipants currently recruited/enrolled2-100 YearsNEI Retinal
08-EI-0043Age-Related Eye Disease Study (AREDS) and AREDS2 Follow-UpNo longer recruiting/follow-up only50-100 YearsNEI Degeneration
08-C-0130A Phase II Trial of Peginterferon alfa-2b (PEG-Intron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform NeurofibromasCompleted Study; data analyses ongoing0-21 YearsNCI Peripheral
08-C-0079Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromatosis Type 1No longer recruiting/follow-up only0-125 YearsNCI Peripheral
07-N-0122Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous SystemCompleted Study; data analyses ongoing18-125 YearsNINDSPeripheral
05-H-0130Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell TransplantsParticipants currently recruited/enrolled7-80 YearsNHLBIPeripheral
04-C-0238A Phase 2 Study of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Von Hippel Lindau Disease and Renal TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Retinal
03-H-0170Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease (SCD) and B-ThalassemiaNo longer recruiting/follow-up only2-80 YearsNHLBIPeripheral
03-EI-0033X-Linked Juvenile Retinoschisis - Clinical and Molecular StudiesParticipants currently recruited/enrolled0-125 YearsNEI Degeneration
02-I-0286Efficacy of Tyrosine Kinase Inhibition in Reducing Eosinophilia in Patients with Myeloid and/or Steroid-Refractory Hypereosinophilic SyndromeParticipants currently recruited/enrolled2-125 YearsNIAIDPeripheral
02-H-0250A Phase I/II Study of HLA-matched Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation for Advanced Mycosis Fungoides/Sezary Syndrome Using Nonmyeloablative Conditioning with Campath-1HCompleted Study; data analyses ongoing18-100 YearsNHLBIPeripheral
02-C-0064Collection of Peripheral Blood and/or Urine From Patients Undergoing Radiation TherapyEnrolling by Invitation18-125 YearsNCI Peripheral
00-N-0043Clinical and Molecular Manifestations of Inherited Neurological DisordersParticipants currently recruited/enrolled2-120 YearsNINDSPeripheral
99-H-0050Non-Myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in High Risk Patients and in Patients with Debilitating Hematologic DiseasesCompleted Study; data analyses ongoing2-80 YearsNHLBIPeripheral
96-H-0049Use of Granulocyte Colony Stimulating Factor (G-CSF) Mobilized Leukapheresis Collections from Healthy Volunteers to Develop Improved Methods of Stem Cell and Lymphocyte Selection for Allogeneic TransplantationParticipants currently recruited/enrolled18-60 YearsNHLBIPeripheral
94-I-0079Eosinophil Activation and Function in Parasitic Infections and Other Conditions with Increased Tissue or Peripheral Blood Eosinophilia in HumansParticipants currently recruited/enrolled1-100 YearsNIAIDPeripheral
94-I-0073Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and GranulocytesParticipants currently recruited/enrolled18-70 YearsNIAIDPeripheral
94-HG-0105An Exploratory Study of the Genetics, Pathophysiology, and Natural History of Autoinflammatory DiseasesParticipants currently recruited/enrolled0-115 YearsNHGRIRetinal
93-I-0063Study of the Immunopathogenesis, Natural History, and Genetics of Autoimmune Lymphoproliferative Syndrome (ALPS) Associated with an Expansion of CD4-8-/TCR alpha/beta+ T CellsParticipants currently recruited/enrolled0-99 YearsNIAIDPeripheral
92-I-0125A Study of Viral Burden in Peripheral Blood Versus Lymphoid and Bone Marrow Tissue in HIV-Infected IndividualsParticipants currently recruited/enrolled18-125 YearsNIAIDPeripheral
91-I-0140Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in HIV-Infected and HIV-Uninfected VolunteersParticipants currently recruited/enrolled18-125 YearsNIAIDPeripheral
91-AR-0196Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related DiseasesNo longer recruiting/follow-up only16-125 YearsNIAMSDegeneration
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