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Protocol Number Title Protocol Status Min-Max Age Institute Keywords
000404-CA Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects with VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) SyndromeParticipants currently recruited/enrolled18-75 YearsNCI Lung Disease Immunodeficiency
000272-HDefining the Genetic Etiology of Suppurative Lung Disease in Children and AdultsParticipants currently recruited/enrolled5-45 YearsNHLBILung Disease Immunodeficiency
18-C-0135Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or DysregulationParticipants currently recruited/enrolled4-125 YearsNCI Lung Disease Immunodeficiency
16-C-0003Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary ImmunodeficienciesParticipants currently recruited/enrolled4-75 YearsNCI Lung Disease Immunodeficiency
14-I-0146The Pathogenesis and Genetics of Disseminated or Refractory CoccidioidomycosisParticipants currently recruited/enrolled2-100 YearsNIAIDLung Disease Immunodeficiency
09-H-0172Natural History of BronchiectasisParticipants currently recruited/enrolled5-125 YearsNHLBILung Disease Immunodeficiency
00-I-0159Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)Participants currently recruited/enrolled0-125 YearsNIAIDLung Disease Immunodeficiency
00-HG-0209Molecular and Clinical Studies of Primary Immunodeficiency DiseasesNo longer recruiting/follow-up only3-125 YearsNHGRILung Disease Immunodeficiency
001084-CHA Prospective Natural History Study of Lymphatic AnomaliesParticipants currently recruited/enrolled0-125 YearsNICHDLung Disease
000809-IA Pilot Study of Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated ColitisParticipants currently recruited/enrolled10-60 YearsNIAIDDisease Immunodeficiency
000697-HU01 Cooperative Assessment of Late Effects for SCD Curative Therapies (COALESCE)Participants currently recruited/enrolled18-65 YearsNHLBILung Disease
000520-CPhase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG with or without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung CancerRecruitment has not started18-125 YearsNCI Lung Disease
000392-IMetabolic Profiling of Immune Responses in Immune-Mediated DiseasesParticipants currently recruited/enrolled18-75 YearsNIAIDDisease Immunodeficiency
000387-HThe Natural History of Acquired and Inherited Bone Marrow Failure Syndromes.Participants currently recruited/enrolled2-125 YearsNHLBILung Disease
000152-ENatural History of The Human Biological Response to Environmental Exposure and InjuryParticipants currently recruited/enrolled18-125 YearsNIEHSLung Disease
000124-CA Phase 2 Study of the MEK inhibitor Trametinib (IND #119346, NSC# 763093) in Children with Relapsed or Refractory Juvenile Myelomonocytic LeukemiaRecruitment has not started2-21 YearsNCI Lung Disease
21-C-0026A Phase I/II Study of Abemaciclib in Patients with HIV-associated and HIV-negative Kaposi SarcomaParticipants currently recruited/enrolled18-125 YearsNCI Lung Immunodeficiency
20-I-0132A Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)Participants currently recruited/enrolled12-130 YearsNIAIDLung Disease
20-H-0158Natural History Study: Gene First Approach to Connective Tissue DiseaseParticipants currently recruited/enrolled2-100 YearsNHLBILung Disease
20-H-0099Data Collection of Standard Care and Evaluation of NHLBI Patients and DonorsEnrolling by Invitation2-120 YearsNHLBILung Disease
20-C-0167Close Assessment and Testing for Chronic Graft-vs-Host Disease (CATCH Study)Participants currently recruited/enrolled18-125 YearsNCI Disease Immunodeficiency
20-C-0097A Phase II, Open-Label Trial of Bintrafusp Alfa (M7824) in Subjects with Thymoma and Thymic CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Lung Disease
20-C-0070A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Patients with Inborn Errors of ImmunityParticipants currently recruited/enrolled4-69 YearsNCI Disease Immunodeficiency
20-C-0062A phase 1b Study of Nivolumab in Patients with Autoimmune Disorders and Advanced Malignancies (AIM-NIVO)Participants currently recruited/enrolled18-125 YearsNCI Lung Disease
20-C-0011Phase 1 Study of Recombinant Human IL-15 (rhIL-15) and Mogamulizumab for Patients with Refractory or Relapsed Adult T-Cell Leukemia and Mycosis Fungoides/Sezary SyndromeCompleted Study; data analyses ongoing18-125 YearsNCI Lung Immunodeficiency
19-I-0069Phase I Open-Label Study of Safety and Immunogenicity of AD4-HIV Envelope Vaccine Vectors in Healthy VolunteersParticipants currently recruited/enrolled18-65 YearsNIAIDDisease Immunodeficiency
18-I-0128Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary ImmunodeficienciesParticipants currently recruited/enrolled0-99 YearsNIAIDDisease Immunodeficiency
18-I-0041Investigating the Mechanistic Biology of Primary Immunodeficiency DisordersParticipants currently recruited/enrolled0-75 YearsNIAIDDisease Immunodeficiency
18-H-0108Vascular Disease Discovery ProtocolParticipants currently recruited/enrolled2-100 YearsNHLBILung Disease
18-H-0004Low Dose Danazol for the Treatment of Telomere Related DiseasesParticipants currently recruited/enrolled3-125 YearsNHLBILung Disease
18-CC-0087Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy VolunteersCompleted Study; data analyses ongoing18-65 YearsCC Lung Immunodeficiency
17-N-0131Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal DementiaParticipants currently recruited/enrolled18-125 YearsNINDSLung Disease
17-H-0091Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn, Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells, to Expedite Engraftment and Improve Transplant OutcomeParticipants currently recruited/enrolled4-75 YearsNHLBILung Disease
17-C-0174Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman DiseaseParticipants currently recruited/enrolled18-125 YearsNCI Disease Immunodeficiency
16-I-0165An open-label, non-randomized extension study to evaluate the long term safety, tolerability, efficacy and pharmacokinetics of CDZ173 (leniolisib) in patients with APDS/PASLI (Activated phosphoinositide 3-kinase delta syndrome/p110 delta-activating mutatNo longer recruiting/follow-up only12-75 YearsNIAIDDisease Immunodeficiency
16-E-0096Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage FunctionParticipants currently recruited/enrolled18-65 YearsNIEHSLung Disease
16-C-0154A Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 for HPV-Associated CancersParticipants currently recruited/enrolled18-125 YearsNCI Lung Disease
16-C-0094A Phase 1/2 Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease (cGVHD) after Allogeneic Hematopoietic Stem Cell Transplantation (SCT)No longer recruiting/follow-up only18-125 YearsNCI Lung Disease
16-C-0066Phase I Study of MK-3475 (Pembrolizumab) in Patients with Human Immunodeficiency Virus (HIV) and Relapsed/Refractory or Disseminated Malignant NeoplasmParticipants currently recruited/enrolled18-125 YearsNCI Lung Immunodeficiency
15-I-0135An open-label, non-randomized, within-patient dose-finding study followed by a randomized, subject, investigator and sponsor-blinded placebo controlled study to assess the efficacy and safety of CDZ173 (leniolisib) in patients with APDS/PASLI (Activated Completed Study; data analyses ongoing12-75 YearsNIAIDDisease Immunodeficiency
15-C-0067A Phase I/II Open Label, Dose Escalation Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell TransplantationParticipants currently recruited/enrolled18-125 YearsNCI Lung Disease
14-I-0194Screening of Volunteers for Clinical Trials of Investigational or Licensed Vaccines or Antiviral ProductsParticipants currently recruited/enrolled18-65 YearsNIAIDLung Disease
14-I-0039Elite Controller and ART-Treated HIV+ Statin Versus ASA Treatment Intervention StudyCompleted Study; data analyses ongoing18-125 YearsNIAIDDisease Immunodeficiency
13-HG-0199NIH Participation to USIDNET RegistryParticipants currently recruited/enrolled0-125 YearsNHGRIDisease Immunodeficiency
13-CC-0012A Natural History Study of Novel Biomarkers in Pulmonary Arterial HypertensionParticipants currently recruited/enrolled18-125 YearsCC Lung Disease
13-C-0132Allogeneic Hematopoietic Stem Cell Transplant for Patients with Mutations in GATA2 or the MonoMAC SyndromeParticipants currently recruited/enrolled8-70 YearsNCI Disease Immunodeficiency
13-C-0131Inpatient Hospice with Procurement of Tissue on Expiration in Thoracic Malignancies, Bladder Cancer, Ovarian Cancer, Epithelial Cancer and Patients Treated with an Adoptive Cellular TherapyParticipants currently recruited/enrolled18-125 YearsNCI Lung Disease
11-H-0209Male Hormones for Telomere Related DiseasesCompleted Study; data analyses ongoing2-125 YearsNHLBILung Disease
11-H-0046Cross-Sectional Characterization of Idiopathic BronchiectasisCompleted Study; data analyses ongoing18-125 YearsNHLBILung Disease
11-E-0072Environmental Risk Factors for the Anti-Synthetase SyndromeParticipants currently recruited/enrolled2-100 YearsNIEHSLung Disease
10-I-0148Natural History of Severe Allergic Inflammation and ReactionsParticipants currently recruited/enrolled2-80 YearsNIAIDLung Disease
10-I-0109VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and OlderParticipants currently recruited/enrolled18-125 YearsNIAIDLung Disease
10-H-0126Cardiovascular Disease Discovery ProtocolParticipants currently recruited/enrolled1-100 YearsNHLBILung Disease
10-CC-0053Collection of Bone Marrow from Healthy Volunteers and Patients for the Production of Clinical Bone Marrow Stromal Cell (BMSC) ProductsCompleted Study; data analyses ongoing18-125 YearsCC Disease Immunodeficiency
10-C-0201Apheresis and CD34+ Selection of Mobilized Peripheral Blood CD34+ Cells from Patients with DOCK8 Deficiency, LAD-1, and GATA2 DeficiencyParticipants currently recruited/enrolled18-40 YearsNCI Disease Immunodeficiency
09-I-0200A Phase I Study of MozobilTM in the Treatment of Patients with WHIMSParticipants currently recruited/enrolled18-75 YearsNIAIDLung Immunodeficiency
09-I-0133Establishing Fibroblast-derived Cell Lines from Skin/Tissue Biopsies of Patients with Immunodeficiency or Immunodysregulation DisordersEnrolling by Invitation2-85 YearsNIAIDDisease Immunodeficiency
09-I-0102Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ LymphocytopeniaParticipants currently recruited/enrolled18-125 YearsNIAIDDisease Immunodeficiency
09-I-0086Screening Protocol for Genetic Diseases of Allergic InflammationParticipants currently recruited/enrolled0-99 YearsNIAIDDisease Immunodeficiency
09-C-0024A Phase I Study of Quadrivalent Human Papilloma Virus (HPV) (Types 6, 11, 16, 18) Recombinant Vaccine in HIV-Infected and HIV-Negative Pre-Adolescents, Adolescents and Young AdultsCompleted Study; data analyses ongoing12-26 YearsNCI Disease Immunodeficiency
07-H-0142Research Respiratory Tract ProceduresParticipants currently recruited/enrolled10-125 YearsNHLBILung Disease
07-H-0113Procurement and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples from Healthy Volunteers to Support Clinical and Translational Research Projects in the NHLBIParticipants currently recruited/enrolled8-125 YearsNHLBILung Disease
06-I-0015Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell DeathParticipants currently recruited/enrolled0-125 YearsNIAIDDisease Immunodeficiency
06-H-0217Genetic Disorders of Mucociliary ClearanceCompleted Study; data analyses ongoing2-65 YearsNHLBILung Disease
06-C-0014Prospective Evaluation of Genetic and Epigenetic Alterations in Patients with Thoracic MalignanciesParticipants currently recruited/enrolled2-125 YearsNCI Lung Disease
05-I-0213Screening and Baseline Assessment of Patients with Abnormalities of Immune FunctionParticipants currently recruited/enrolled0-125 YearsNIAIDLung Immunodeficiency
01-I-0202Natural History, Genetics, Phenotype, and Treatment of Mycobacterial InfectionsParticipants currently recruited/enrolled0-100 YearsNIAIDLung Disease
01-C-0129Eligibility Screening for the NIH Intramural Research Program Clinical ProtocolsEnrolling by Invitation0-125 YearsNCI Lung Immunodeficiency
01-AR-0227Studies of the Natural History of Rheumatic Disease in Minority CommunitiesParticipants currently recruited/enrolled18-100 YearsNIAMSLung Disease
96-H-0100Role of Genetic Factors in the Pathogenesis of Lung DiseaseParticipants currently recruited/enrolled2-90 YearsNHLBILung Disease
95-I-0066Genetic Analysis of Immune DisordersParticipants currently recruited/enrolled0-125 YearsNIAIDDisease Immunodeficiency
94-I-0079Eosinophil Activation and Function in Parasitic Infections and Other Conditions with Increased Tissue or Peripheral Blood Eosinophilia in HumansParticipants currently recruited/enrolled1-100 YearsNIAIDLung Disease
94-DK-0133Genetic Markers for Focal Segmental GlomerulosclerosisCompleted Study; data analyses ongoing1-125 YearsNIDDKDisease Immunodeficiency
93-I-0119Detection and Characterization of Host Defense DefectsParticipants currently recruited/enrolled0-125 YearsNIAIDLung Disease
91-AR-0196Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related DiseasesParticipants currently recruited/enrolled16-125 YearsNIAMSLung Disease
89-I-0158Studies of Immune Regulation in Patients with Common Variable Immunodeficiency and Related Humoral Immunodeficiency SyndromesParticipants currently recruited/enrolled2-125 YearsNIAIDLung Immunodeficiency
88-I-0083Host Response to Infection and Treatment in the Filarial Diseases of HumansParticipants currently recruited/enrolled3-100 YearsNIAIDLung Disease
001516-CPhase I Study of Aerosolized Antibiotics and Pembrolizumab in Advanced Non-Small Cell Lung CancerRecruitment has not started10-120 YearsNCI Lung
001146-IA Repository to Study Host-Microbiome Interactions in Health and DiseaseParticipants currently recruited/enrolled0-125 YearsNIAIDDisease
001126-DCCollection of Clinical Data and Specimens for Research in Hearing, Balance and Communication DisordersParticipants currently recruited/enrolled2-125 YearsNIDCDLung
001061-HObservational Study Investigating the Mechanistic Effects of Mitapivat in Subjects with Sickle Cell DiseaseEnrolling by Invitation16-125 YearsNHLBILung
001048-IA Phase 1/2 Randomized, Double-Blinded, Placebo-Controlled Trial Evaluating the Immunogenicity and Safety of an Adjuvanted Epstein-Barr Virus (EBV) Glycoprotein 350 Vaccine in EBV-Seronegative PersonsRecruitment has not started18-22 YearsNIAIDDisease
001032-CBAY 1895344 Plus Topoisomerase-1 (Top1) Inhibitors in Patients with Advanced Solid Tumors, Phase I Studies with Expansion Cohorts in Small Cell Lung Carcinoma (SCLC), Poorly Differentiated Neuroendocrine Carcinoma (PD-NEC) and Pancreatic Adenocarcinoma (Recruitment has not started18-125 YearsNCI Lung
000958-CProspective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor MicroenvironmentEnrolling by Invitation18-125 YearsNCI Lung
000954-CA Phase 1/2 Single Arm Open-Label Clinical Trial of TC-510 In Patients with Advanced Mesothelin-Expressing CancerParticipants currently recruited/enrolled18-125 YearsNCI Lung
000894-ARNatural History of Inflammatory Muscle DiseasesRecruitment has not started12-125 YearsNIAMSDisease
000829-HControls and Healthy Vasculature InitiativeParticipants currently recruited/enrolled18-125 YearsNHLBIDisease
000821-IAn Open-Label, Single-Arm, Phase 1/2 Dose-Escalation Trial of Long-Acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 LymphopeniaRecruitment has not started18-75 YearsNIAIDDisease
000740-CHA Phase 3 Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Chronocort in the Treatment of Participants Aged 16 Years and Over with Congenital Adrenal HyperplasiaEnrolling by Invitation18-125 YearsNICHDDisease
000731-CA First-In-Human, Open-Label, Multicenter Study of VOR33 in Patients with Acute Myeloid Leukemia who are at High-Risk for Leukemia Relapse following Hematopoietic Cell TransplantationParticipants currently recruited/enrolled18-70 YearsNCI Lung
000688-ILongitudinal Observations of Vaccine Responses to SARS-CoV-2 and other Emerging Infectious DiseasesParticipants currently recruited/enrolled18-125 YearsNIAIDDisease
000674-MAssessment of [18F]SF12051 for Imaging the 18-kDa Translocator Protein (TSPO) in Brain and Whole Body of Healthy SubjectsParticipants currently recruited/enrolled18-99 YearsNIMH Disease
000665-DKA Randomized Double-Blind Placebo-Controlled Study of the LEPR Agonist Antibody REGN4461 for the Treatment of Metabolic Abnormalities in Patients with Familial Partial LipodystrophyParticipants currently recruited/enrolled18-125 YearsNIDDKDisease
000643-CPhase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)Participants currently recruited/enrolled18-125 YearsNCI Lung
000633-CPhase 1/2 Study of VIP152, Venetoclax, and Prednisone (VVIP) in Relapsed/Refractory Lymphoid MalignanciesParticipants currently recruited/enrolled18-125 YearsNCI Disease
000613-CPhase I/II Trial to Determine the Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination with Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis after Reduced Intensity Conditioning and Peripheral Blood StParticipants currently recruited/enrolled12-125 YearsNCI Lung
000612-CPhase 1 Study of NT-I7 (rhIL-7-hyFc) for the Treatment of Kaposi Sarcoma in Patients With or Without Infection with HIVParticipants currently recruited/enrolled18-125 YearsNCI Immunodeficiency
000547-HGObservational Study of Advanced Data Analytics in Genetic ConditionsRecruitment has not started0-125 YearsNHGRIDisease
000491-CTissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)Participants currently recruited/enrolled18-125 YearsNCI Lung
000489-CPhase I/II Study Using Prophylactic Donor Lymphocyte Infusion Early Post-Transplant After Allogeneic Hematopoietic Cell Transplantation Using Post-Transplantation Cyclophosphamide for High-Risk Hematologic MalignanciesClinical hold/Recruitment or enrollment suspended12-125 YearsNCI Lung
000487-CHNatural History Investigation into Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol MetabolismParticipants currently recruited/enrolled0-125 YearsNICHDDisease
000486-CA Phase 1 Trial of the ATR Inhibitor BAY 1895344 in Combination with Cisplatin and with Cisplatin Plus Gemcitabine in Advanced Solid Tumors with an Emphasis on Urothelial CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Lung
000479-HObservational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative TherapiesParticipants currently recruited/enrolled18-125 YearsNHLBILung
000478-CA Phase I/II Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Bone Marrow Transplantation Followed by GVHD Prophylaxis with Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies in People Living with HIV (PLWH)Participants currently recruited/enrolled12-125 YearsNCI Immunodeficiency
000464-HEvaluation of Clonal Hematopoiesis in Patients with Sickle Cell Disease Receiving Curative TherapiesEnrolling by Invitation4-125 YearsNHLBIDisease
000428-NAn Observational Study to Assess Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)Participants currently recruited/enrolled18-125 YearsNINDSLung
000418-CPhase 1/2a, Open-label, Multicenter Study of Intramuscular PRL-02 Depot in Patients with Advanced Prostate CancerParticipants currently recruited/enrolled18-120 YearsNCI Lung
000410-IVRC 325 (000410): A Phase I Open-Label Clinical Trial to Evaluate the Dose, Safety, Tolerability and Immunogenicity of Mosaic Quadrivalent Influenza Vaccine with and without Adjuplex Compared with a Licensed Inactivated Seasonal QIV, In Healthy AdultsParticipants currently recruited/enrolled18-50 YearsNIAIDLung
000359-CPhase I/II study to reduce post-transplantation cyclophosphamide dosing for older or unfit patients undergoing bone marrow transplantation for hematologic malignanciesParticipants currently recruited/enrolled12-85 YearsNCI Lung
000356-CA Phase I/II Trial of BMS-986253 in Myelodysplastic SyndromesParticipants currently recruited/enrolled18-125 YearsNCI Disease
000344-DKNatural History Study of Parathyroid DisordersParticipants currently recruited/enrolled0-125 YearsNIDDKDisease
000343-HDetection of T cell Somatic Mutations in Bone Marrow Failure Using Whole Exome or Targeted SequencingEnrolling by Invitation18-125 YearsNHLBIDisease
000337-CNatural History Study of KSHV-Associated Multicentric Castleman's DiseaseParticipants currently recruited/enrolled18-125 YearsNCI Lung
000331-IInvestigating the Human Immune Response to Ixodes scapularis Tick BitesParticipants currently recruited/enrolled18-99 YearsNIAIDDisease
000324-CPhase 1/2 Dose Escalation Study of CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults with Recurrent or Refractory CD19/CD22-expressing B Cell MalignanciesParticipants currently recruited/enrolled3-35 YearsNCI Lung
000299-HTechnical Development of Cardiovascular MRIParticipants currently recruited/enrolled18-125 YearsNHLBILung
000291-IObservational Digital Biomarker Discovery in Respiratory Virus Challenge StudiesRecruitment has not started18-65 YearsNIAIDDisease
000288-CA Phase II, Open-Label, Single-Arm Study of Berzosertib (M6620) in Combination with Topotecan in Participants with Relapsed Platinum-Resistant Small-Cell Lung CancerCompleted Study; data analyses ongoing18-125 YearsNCI Lung
000277-CImaging and Biopsy of HIV-Infected Individuals Undergoing Analytic Treatment InterruptionParticipants currently recruited/enrolled18-125 YearsNCI Immunodeficiency
000247-DKEvaluation of Patients with Gastrointestinal DiseaseParticipants currently recruited/enrolled18-125 YearsNIDDKDisease
000236-IA Phase 1 Study of Empagliflozin as Treatment for Severe Congenital Neutropenia Due to G6PC3 DeficiencyParticipants currently recruited/enrolled18-125 YearsNIAIDLung
000226-IEfficacy of Belimumab and Rituximab Compared to Rituximab Alone for the Treatment of Primary Membranous NephropathyParticipants currently recruited/enrolled18-75 YearsNIAIDDisease
000207-ARThe Natural History of Coronavirus Disease (COVID-19) in Systemic Autoimmune Diseases; An Observational Prospective StudyParticipants currently recruited/enrolled15-125 YearsNIAMSDisease
000201-IPediatric SARS-CoV-2 and MIS-C Long-term Follow-upParticipants currently recruited/enrolled0-21 YearsNIAIDLung
000187-EIAdaptive Optics Imaging of Outer Retinal DiseasesParticipants currently recruited/enrolled21-125 YearsNEI Disease
000186-IPart B- Phase I/II, Non-randomized, Multicenter, Open-label Study of G1XCGD (Lentiviral Vector Transduced CD34+ Cells) in Patients with X-Linked Chronic Granulomatous DiseaseClinical hold/Recruitment or enrollment suspended3-12 YearsNIAIDLung
000183-IAn open-label single-arm Phase IIb study of F901318 as treatment of invasive fungal infections due to Lomentospora prolificans, Scedosporium spp., Aspergillus spp., and other resistant fungi in patients lacking suitable alternative treatment optionsParticipants currently recruited/enrolled16-125 YearsNIAIDLung
000176-CA Phase I/II Trial of Lurbinectedin with Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and High Grade Neuroendocrine CancersParticipants currently recruited/enrolled18-125 YearsNCI Lung
000144-CA Phase I/II Study of Sacituzumab Govitecan plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP InhibitorsParticipants currently recruited/enrolled18-125 YearsNCI Lung
000134-IA Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Trial of Intravenous Zotatifin in Adults with Mild or Moderate Coronavirus Disease 2019 (COVID-19)Participants currently recruited/enrolled18-125 YearsNIAIDLung
000102-CCCOVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE): A Randomized Controlled TrialParticipants currently recruited/enrolled18-80 YearsCC Lung
000064-IA Phase 1/2 Open-label Study to Evaluate the Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease with Inflammatory ComplicationsEnrolling by Invitation18-125 YearsNIAIDLung
000062-CPhase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants with Pleural Mesotheliomas, or Pleural Effusions from Cancers Expressing MesothelinParticipants currently recruited/enrolled18-120 YearsNCI Lung
000059-CPhase I Study of Intratumor Injection of anti-Mesothelin Immunotoxin LMB-100 with Ipilimumab in Malignant MesotheliomaParticipants currently recruited/enrolled18-125 YearsNCI Lung
000057-CA Phase 1 Study of AZD8186 in Combination with Docetaxel in Patients with PTEN Mutated or PIK3CB Mutated Advanced Solid Tumors, Potentially Amenable to DocetaxelCompleted Study; data analyses ongoing18-125 YearsNCI Lung
000051-NNIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)Participants currently recruited/enrolled48-70 YearsNINDSLung
000049-HEvaluation of the Safety,Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects with Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of MitapivatNo longer recruiting/follow-up only18-70 YearsNHLBILung
000045-CA Phase I Trial of T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and other KK-LC-1 Positive Epithelial CancersParticipants currently recruited/enrolled18-120 YearsNCI Lung
000037-CCDevelopment and Evaluation of Techniques for Computer Aided Detection and Diagnosis from Existing Radiologic ImagesNo longer recruiting/follow-up only0-125 YearsCC Disease
000030-CPhase 2 Study of Bintrafusp alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON).Participants currently recruited/enrolled18-125 YearsNCI Lung
22-DK-0002Effect of Ultra-processed versus Unprocessed Diets on Energy MetabolismParticipants currently recruited/enrolled18-60 YearsNIDDKDisease
22-C-0005Phase I Dose Escalation and Expansion Study of Tazemetostat in Combination with Topotecan and Pembrolizumab in Recurrent Small Cell Lung CancerParticipants currently recruited/enrolled18-125 YearsNCI Lung
21-I-0029Natural history, epidemiology and pathogenesis of severe HPV-related diseases (Neptune)Participants currently recruited/enrolled3-125 YearsNIAIDDisease
21-I-0003A Phase 1/2 Study to Evaluate the Safety, Tolerability and Efficacy, of JSP191 for Hematopoietic Cell Transplantation Conditioning to Achieve Engraftment and Immune Reconstitution in Subjects with SCIDParticipants currently recruited/enrolled3-125 YearsNIAIDImmunodeficiency
21-HG-0020Caregiving Networks Across Disease Context and the Life Course: A Comparative Longitudinal StudyParticipants currently recruited/enrolled18-125 YearsNHGRIDisease
21-H-0027Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens into the Human LungParticipants currently recruited/enrolled18-64 YearsNHLBILung
21-CH-0028A Pilot Study to Evaluate a Noninvasive Multimodal Biosensing Device for Screening and Monitoring Response to Treatment of Infectious Respiratory Diseases.Participants currently recruited/enrolled18-125 YearsNICHDDisease
21-C-0024A Phase 2 Adaptive Study of Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in Patients with High-Risk Smoldering Multiple MyelomaParticipants currently recruited/enrolled18-125 YearsNCI Lung
21-C-0019Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients with Relapsed/Refractory Hairy Cell Leukemia and VariantParticipants currently recruited/enrolled18-125 YearsNCI Lung
20-M-0082Phase 1 Study: PET Imaging of Cyclooxygenases in Neurodegenerative Brain DiseaseParticipants currently recruited/enrolled18-99 YearsNIMH Disease
20-I-0160Dose-Escalation Study of a Low Pathogenicity Avian H10N7 Influenza Virus in a Healthy Human Challenge ModelRecruitment has not started18-50 YearsNIAIDLung
20-I-0123A Longitudinal Study of COVID-19 Sequelae and ImmunityParticipants currently recruited/enrolled18-125 YearsNIAIDLung
20-I-0088An Open-label Efficacy and Safety Study of Pozelimab in Patients with CD55 deficient Protein-losing Enteropathy (CHAPLE Disease)Participants currently recruited/enrolled3-125 YearsNIAIDLung
20-I-0084Sample Collection for Systems Evaluation of Patients with Unknown or Incompletely Characterized Immune DefectsParticipants currently recruited/enrolled2-125 YearsNIAIDImmunodeficiency
20-I-0037Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning with h-ATG, Radiation, and SirolimusEnrolling by Invitation3-40 YearsNIAIDLung
20-HG-0156A Multicenter, Multinational, Randomized, Double-Blind, Placebo-Controlled Study to Assess The Efficacy, Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Venglustat in Late-Onset GM2 Gangliosidosis (Tay-Sachs Disease And Sandhoff Disease) No longer recruiting/follow-up only2-125 YearsNHGRIDisease
20-HG-0034A Multi-Cohort Phase 2 Dose-Escalation Study of MK-7075 (Miransertib) in Proteus SyndromeParticipants currently recruited/enrolled3-125 YearsNHGRILung
20-H-0068Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell TraitParticipants currently recruited/enrolled18-80 YearsNHLBILung
20-H-0044Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in PsoriasisCompleted Study; data analyses ongoing18-80 YearsNHLBIDisease
20-H-0029An Intravenous, Open-Label, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy VolunteersParticipants currently recruited/enrolled18-125 YearsNHLBIDisease
20-DK-0168LYNC-LD Prospective Multicenter Natural History Study of Lipodystrophy Syndromes to Determine Prevalence, Incidence and Predictors of Diabetes and Severe Hypertriglyceridemia, and their Complications.Participants currently recruited/enrolled3-125 YearsNIDDKDisease
20-DK-0067A Phase 3, Matrix Design, Partially Double-Blind, Randomized Study of the Efficacy and Safety of 50 mg Lonafarnib/100 mg Ritonavir BID with and without 180 mcg PEG IFN-alfa-2a for 48 Weeks Compared with PEG IFN-alfa-2a Monotherapy and Placebo Treatment iNo longer recruiting/follow-up only18-125 YearsNIDDKDisease
20-CC-0113Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons (COVID ARC 19)No longer recruiting/follow-up only18-80 YearsCC Lung
20-C-0149Phase II Trial of Olaparib (LYNPARZA) plus Durvalumab (IMFINZI) in EGFR-Mutated Adenocarcinomas that Transform to Small Cell Lung Cancer (SCLC) and Other Neuroendocrine TumorsParticipants currently recruited/enrolled18-125 YearsNCI Lung
20-C-0106Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients with BAP1 Tumor Predisposition SyndromeParticipants currently recruited/enrolled30-125 YearsNCI Lung
20-C-0098A Phase 1/2, Open Label, Dose-Escalation, Safety and Tolerability Study of NC410 in Subjects with Advanced or Metastatic Solid TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Lung
20-C-0076Phase 2 Trial of Encorafenib plus Binimetinib for Patients with BRAF V600 Mutated Relapsed/Refractory HCLParticipants currently recruited/enrolled18-125 YearsNCI Lung
20-C-0061Phase I/II study of NHS-IL12 Monotherapy and in Combination with M7824 in Advanced Kaposi SarcomaParticipants currently recruited/enrolled18-125 YearsNCI Lung
20-C-0058A Study of Front Line Ibrutinib for Newly Diagnosed Chronic Graft-Versus-Host DiseaseParticipants currently recruited/enrolled18-125 YearsNCI Lung
20-C-0045Phase I/II Trial of Combination Immunotherapy in Subjects with Advanced HPV Associated MalignanciesNo longer recruiting/follow-up only18-125 YearsNCI Lung
20-C-0041Protocol for a Research Database for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic InjuriesEnrolling by Invitation1-125 YearsNCI Disease
20-C-0028Phase 1/2 Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid LeukemiaParticipants currently recruited/enrolled3-35 YearsNCI Lung
20-C-0013Phase I/II Trial of PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell CancersNo longer recruiting/follow-up only18-125 YearsNCI Lung
20-C-0009Randomized Phase II Trial of Topotecan Plus M6620 (VX-970) vs. Topotecan Alone in Patients with Relapsed Small-Cell Lung CancerParticipants currently recruited/enrolled18-125 YearsNCI Lung
20-AA-0057The Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk BehaviorsParticipants currently recruited/enrolled21-65 YearsNIAAADisease
19-NR-0098Patient-Centered Assessment of Symptoms and OutcomesParticipants currently recruited/enrolled18-125 YearsNINR Lung
19-M-0095PET Imaging of Neuroinflammation in Neurodegenerative Diseases via a Novel TSPO RadioligandParticipants currently recruited/enrolled18-125 YearsNIMH Disease
19-M-0079Evaluation of Novel PET Radioligands as Inflammatory Biomarkers in Rheumatoid Arthritis and MyositisParticipants currently recruited/enrolled18-99 YearsNIMH Disease
19-I-0093Collection of Human Biospecimens for Basic and Clinical Research into Globin VariantsParticipants currently recruited/enrolled18-70 YearsNIAIDLung
19-I-0058Mucosal Correlates of Protection After Influenza Viral Challenge of Vaccinated and Unvaccinated Healthy VolunteersCompleted Study; data analyses ongoing18-55 YearsNIAIDLung
19-I-0053Prospective Study to Identify Food-Specific and Component IgE Threshold Levels that Predict Food Allergy in Patients with Elevated Total Serum IgE Levels and Atopic DermatitisParticipants currently recruited/enrolled3-21 YearsNIAIDLung
19-I-0015Phase 1/2 Randomized, Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-lymphocyte Antigen 4 (CTLA4) HaploinsufficiencyParticipants currently recruited/enrolled8-65 YearsNIAIDLung
19-HG-0101A Phase 1/2 Study of Intravenous Gene Transfer with an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 GangliosidosisNo longer recruiting/follow-up only0-12 YearsNHGRIDisease
19-HG-0092New Approaches for Empowering Studies of Asthma in Populations of African DescentCompleted Study; data analyses ongoing18-125 YearsNHGRILung
19-HG-0059Longitudinal Studies of Patients with FPDMMParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
19-H-0139Investigation of the Natural Progression of Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance.Participants currently recruited/enrolled18-125 YearsNHLBILung
19-H-0057Multiple Patient Program for Lamprene (clofazimine) for the treatment of Non-Tuberculous Mycobacterial (NTM) Infections- CLAM320B2002MParticipants currently recruited/enrolled18-99 YearsNHLBILung
19-EI-0056A Survey Study of Retinitis Pigmentosa (RP) Clinical Measures and Repeatability Testing of Potential Outcome Measures.Participants currently recruited/enrolled12-125 YearsNEI Disease
19-DK-0067Effect of Low Fat versus Low Carbohydrate Diets on Energy MetabolismCompleted Study; data analyses ongoing18-50 YearsNIDDKDisease
19-CH-0020A Phase 1-2 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children with Classic 21-Hydroxylase DeficiencyRecruitment has not started2-9 YearsNICHDDisease
19-CC-0063Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Healthy VolunteersParticipants currently recruited/enrolled18-65 YearsCC Immunodeficiency
19-C-0143A Phase II Study Using the Administration of Autologous T-Cells Engineered using the Sleeping Beauty Transposon/Transposase System to Express T-Cell Receptors Reactive Against Mutated Neoantigens in Patients with Metastatic CancerParticipants currently recruited/enrolled18-70 YearsNCI Lung
19-C-0136A Phase 2, Randomized, Multicenter Study to Evaluate the Efficacy and Safety of KD025 in Subjects with Chronic Graft Versus Host Disease (CGVHD) After at Least 2 Prior Lines of Systemic TherapyCompleted Study; data analyses ongoing18-125 YearsNCI Lung
19-C-0127A Phase II Study of LMB-100 Followed by Pembrolizumab in the Treatment of Adults with Mesothelin-Expressing Non-Squamous Non-Small Cell Lung Cancer (NSCLC)No longer recruiting/follow-up only18-125 YearsNCI Lung
19-C-0117A Phase 1 / 2 Single Arm Open-label Clinical Trial of Gavocabtagene Autoleucel (gavo-cel) in Patients with Advanced Mesothelin Expressing CancerParticipants currently recruited/enrolled18-120 YearsNCI Lung
19-C-0085Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Peripheral T cell LymphomaClinical hold/Recruitment or enrollment suspended12-125 YearsNCI Disease
19-C-0076A Phase 1 Study of Interleukin-15 in Combination with Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell MalignanciesCompleted Study; data analyses ongoing18-125 YearsNCI Lung
19-C-0017A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 PatientsParticipants currently recruited/enrolled18-70 YearsNCI Lung
18-I-0139Defining Skin Immunity of a Bite of Key Insect Vectors in HumansCompleted Study; data analyses ongoing18-64 YearsNIAIDDisease
18-I-0092A Phase 2, Open-Label Study to Assess the Immunogenicity of the 9-Valent Human Papillomavirus Recombinant Vaccine in Patients with Idiopathic CD4 T cell LymphocytopeniaParticipants currently recruited/enrolled18-70 YearsNIAIDDisease
18-I-0030VRC 603: A Phase 1 Dose-Escalation Study of the Safety of AAV8-VRC07 (VRC-HIVAAV070-00-GT) Recombinant AAV Vector Expressing VRC07 HIV-1 Neutralizing Antibody in Antiretroviral-Treated, HIV-1 Infected Adults with Controlled ViremiaNo longer recruiting/follow-up only18-65 YearsNIAIDImmunodeficiency
18-HG-0129Reverse Phenotyping Core (RPC)Enrolling by Invitation4-125 YearsNHGRIDisease
18-HG-0064A Natural History Study of Patients with Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)Completed Study; data analyses ongoing0-125 YearsNHGRIDisease
18-H-0118Technical and Translational Development of Cardiovascular MRI (CMR)Participants currently recruited/enrolled7-125 YearsNHLBIDisease
18-H-0090Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH using Peripheral Blood Stem Cells and post-transplant Cyclophosphamide for GVHD prophylaxisParticipants currently recruited/enrolled4-75 YearsNHLBILung
18-H-0012A Phase I Study of HERV-E TCR Transduced Autologous T Cells in Patients with Metastatic Clear Cell Renal Cell CarcinomaParticipants currently recruited/enrolled18-75 YearsNHLBILung
18-H-0011Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner SystemParticipants currently recruited/enrolled18-125 YearsNHLBILung
18-H-0003Discovery of Sirolimus Sensitive Biomarkers in BloodParticipants currently recruited/enrolled18-90 YearsNHLBILung
18-DK-0091Long-Term Follow-Up Of Subjects With CHC Who Achieved A Sustained Virological Response Following Therapy With Direct Acting Antiviral AgentsParticipants currently recruited/enrolled18-125 YearsNIDDKDisease
18-D-0114An Open Label Pilot Study of Denosumab Treatment for Fibrous DysplasiaNo longer recruiting/follow-up only18-125 YearsNIDCRDisease
18-CH-0031Clinical and Molecular Characteristics of Primary Aldosteronism in BlacksParticipants currently recruited/enrolled7-70 YearsNICHDDisease
18-CC-0117PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive SubjectsCompleted Study; data analyses ongoing18-70 YearsCC Immunodeficiency
18-CC-0013A Randomized, Double-Blind, Placebo-Controlled Study of a Single Dose of Pembrolizumab in HIV-Infected PatientsParticipants currently recruited/enrolled18-99 YearsCC Immunodeficiency
18-C-0138An Open-Label Phase 2 Study to Evaluate PT2977 for the Treatment of Von Hippel-Lindau Disease-Associated Renal Cell Carcinoma.No longer recruiting/follow-up only18-125 YearsNCI Disease
18-C-0110Safety Run-In and Phase II Trial of M7824 and Topotecan or Temozolomide in Relapsed Small Cell CancersParticipants currently recruited/enrolled18-125 YearsNCI Lung
18-C-0076Bicalutamide With or Without Metformin for Biochemical Recurrence in Prostate Cancer Patients (BIMET-1)Completed Study; data analyses ongoing18-85 YearsNCI Disease
18-C-0062Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare TumorsCompleted Study; data analyses ongoing2-30 YearsNCI Lung
18-C-0059Phase 1 Dose Escalation Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults with Recurrent or Refractory CD19/CD22-expressing B Cell MalignanciesParticipants currently recruited/enrolled3-39 YearsNCI Lung
18-C-0049A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in Patients with Metastatic CancerParticipants currently recruited/enrolled18-72 YearsNCI Lung
17-M-0179Evaluation of a Novel PET Radioligand to Image Cyclooxygenase-1 (COX-1)Participants currently recruited/enrolled18-99 YearsNIMH Disease
17-I-0163Natural History of Intestinal Inflammation in Patients with Primary Immune DysregulationsParticipants currently recruited/enrolled3-125 YearsNIAIDImmunodeficiency
17-I-0122NIAID Centralized Sequencing ProtocolParticipants currently recruited/enrolled0-125 YearsNIAIDImmunodeficiency
17-I-0016Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)Participants currently recruited/enrolled0-99 YearsNIAIDDisease
17-H-0146Prospective Multicenter Registry On Radiation Dose Estimates of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)Completed Study; data analyses ongoing18-100 YearsNHLBIDisease
17-H-0069Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseParticipants currently recruited/enrolled2-125 YearsNHLBILung
17-CC-0111Pilot Study Characterizing Aerobic Exercise in Women with Systemic Lupus Erythematosus (Exercise SLE Pilot).Completed Study; data analyses ongoing21-80 YearsCC Lung
17-C-0158A Feasibility Study of Mobile Sensor Technologies to Assess General Symptomology of Cancer PatientsEnrolling by Invitation18-125 YearsNCI Lung
17-C-0140Phase I/II Evaluation of Oral Decitabine/Tetrahydrouridine as Epigenetic Priming for Pembrolizumab Immune Checkpoint Blockade in Inoperable Locally Advanced or Metastatic Non-Small Cell Lung Cancers, Esophageal Carcinomas, or Pleural MesotheliomasCompleted Study; data analyses ongoing18-99 YearsNCI Lung
17-C-0117A Phase 1/2a, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-Tumor Activity of PEN-866 in Advanced Solid MalignanciesCompleted Study; data analyses ongoing18-125 YearsNCI Lung
17-C-0105Prospective Study of Clonal Evolution in Follicular LymphomaParticipants currently recruited/enrolled18-125 YearsNCI Disease
17-C-0100Collection of Malignant Ascites, Pleural Fluid and Blood from Patients with Solid TumorsNo longer recruiting/follow-up only18-125 YearsNCI Lung
17-C-0086An Open-label Phase 2 Study to Evaluate PT2385 for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell CarcinomaNo longer recruiting/follow-up only18-125 YearsNCI Disease
17-C-0052Phase II Evaluation of Nivolumab, an Immune Checkpoint Inhibitor, alone or in combination with Oral Decitabine/Tetrahydrouridine as Second Line Therapy for Non-Small Cell Lung CancerCompleted Study; data analyses ongoing18-125 YearsNCI Lung
17-C-0048Anti-CD30 CAR T Cells with Fully-human Binding Domains for Treating CD30-expressing Lymphomas Including Anaplastic Large Cell LymphomasCompleted Study; data analyses ongoing18-73 YearsNCI Immunodeficiency
16-I-0065Screening for Alpha Globin DeletionsParticipants currently recruited/enrolled18-39 YearsNIAIDDisease
16-HG-0156The Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic AcidemiaParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
16-HG-0017Genomic Services Research ProgramParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
16-H-0074Williams Syndrome (WS) and Supravalvular Aortic Stenosis (SVAS) DNA and Tissue BankParticipants currently recruited/enrolled0-85 YearsNHLBIDisease
16-H-0063Williams Syndrome Skin and Vascular Elasticity Study (WS-SAVE Study)Completed Study; data analyses ongoing1-70 YearsNHLBIDisease
16-EI-0169A Pilot Study to Investigate Ustekinumab (STELARA) for the Treatment of Active Sight-Threatening UveitisCompleted Study; data analyses ongoing18-125 YearsNEI Disease
16-EI-0134Studies of the Natural History, Pathogenesis and Outcome of Ocular DisordersParticipants currently recruited/enrolled0-125 YearsNEI Disease
16-EI-0104Clinical and Molecular Studies in Families with Inherited Eye DiseaseParticipants currently recruited/enrolled4-125 YearsNEI Disease
16-EI-0024Rod and Cone Mediated Function in Retinal DiseaseParticipants currently recruited/enrolled5-125 YearsNEI Disease
16-DK-0125Evaluation of Adults with Endocrine-Related ConditionsParticipants currently recruited/enrolled18-100 YearsNIDDKDisease
16-DK-0068The Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and its Role in MetabolismParticipants currently recruited/enrolled18-125 YearsNIDDKDisease
16-CH-0113Evaluation of Children with Endocrine and Metabolic-Related ConditionsParticipants currently recruited/enrolled0-100 YearsNICHDDisease
16-CC-0162Longitudinal Changes in the Oral and Gut Microbiome of Individuals with Alcohol DependenceCompleted Study; data analyses ongoing18-125 YearsCC Disease
16-CC-0112Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted with Cobicistat in Healthy VolunteersCompleted Study; data analyses ongoing18-65 YearsCC Immunodeficiency
16-C-0171Phase I/II Study of Lenalidomide Combined with Modified DA-EPOCH and Rituximab (EPOCH-R2) in Primary Effusion Lymphoma or KSHV-Associated Large Cell LymphomaParticipants currently recruited/enrolled18-125 YearsNCI Lung
16-C-0128A Phase I/II Study of Mesothelin-Targeted Immunotoxin LMB-100 Alone or in Combination with Nab-Paclitaxel in Participants with Previously Treated Metastatic and/ or Locally Advanced Pancreatic Ductal Adenocarcinoma and Mesothelin Expressing Solid TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Lung
16-C-0107A Phase I/II Trial of EP0057, a Nanoparticle Camptothecin with Olaparib in Patients with Relapsed/Refractory Small Cell Lung, Bladder and Prostate CancersParticipants currently recruited/enrolled18-125 YearsNCI Lung
16-C-0092A Pilot Study of Local Ablative Therapy for Treatment of Oligoprogressive, EGFR-mutated, Non-Small Cell Lung Cancer (NSCLC) After Treatment with Osimertinib (AZD9291, Tagrisso)Completed Study; data analyses ongoing18-125 YearsNCI Lung
16-C-0061Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy ProtocolsParticipants currently recruited/enrolled18-125 YearsNCI Lung
16-C-0060A Phase 1b/2 Study of alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Stem Cell TransplantationParticipants currently recruited/enrolled18-125 YearsNCI Lung
16-C-0047A Phase 1 Trial of Pomalidomide in Combination with Liposomal Doxorubicin in Patients with Advanced or Refractory Kaposi SarcomaParticipants currently recruited/enrolled18-125 YearsNCI Lung
16-C-0034A Phase II Trial of Oral Pazopanib plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) without Prior Bevacizumab Exposure and (B) after Failing Prior BevacizumabCompleted Study; data analyses ongoing18-125 YearsNCI Lung
16-C-0027A Prospective Randomized and Phase II Trial for Metastatic Melanoma Using Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of PembrolizumabParticipants currently recruited/enrolled18-70 YearsNCI Lung
15-N-0125Natural History Study of Inflammatory and Infectious Diseases of the Nervous SystemParticipants currently recruited/enrolled2-125 YearsNINDSDisease
15-N-0073A Phase I Study of Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal NeuropathyParticipants currently recruited/enrolled3-99 YearsNINDSLung
15-I-0148A Phase I Study of Respiratory Syncytial Virus Human Challenge in Healthy Adult VolunteersCompleted Study; data analyses ongoing18-50 YearsNIAIDLung
15-I-0131Xenodiagnosis after Antibiotic Treatment for Lyme Disease - Phase II StudyCompleted Study; data analyses ongoing18-125 YearsNIAIDDisease
15-I-0056Collection of Plasma from Subjects that Recovered From or Were Vaccinated To Emerging Infectious DiseasesEnrolling by Invitation18-70 YearsNIAIDDisease
15-HG-0130Clinical and Genetic Evaluation of Patients with Undiagnosed Disorders Through the Undiagnosed Diseases NetworkParticipants currently recruited/enrolled0-100 YearsNHGRIDisease
15-H-0190Human Biospecimen Procurement and Analysis to Support Translational Research to Identify Genetic Etiology and Disease Mechanism(s) in Rare Genetic Vascular/Cardiovascular DiseasesParticipants currently recruited/enrolled0-125 YearsNHLBIDisease
15-H-0017Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary FibrosisCompleted Study; data analyses ongoing18-100 YearsNHLBILung
15-EI-0128The Genetics of Inherited Eye DiseaseParticipants currently recruited/enrolled0-125 YearsNEI Disease
15-EI-0020Adaptive Optics Retinal ImagingParticipants currently recruited/enrolled12-125 YearsNEI Disease
15-E-0058Natural History of Asthma with Longitudinal Environmental SamplingParticipants currently recruited/enrolled18-60 YearsNIEHSLung
15-DK-0108Natural History of Noncirrhotic Portal HypertensionParticipants currently recruited/enrolled12-125 YearsNIDDKDisease
15-DK-0079Observational Study of Hepatitis B Virus (HBV) in Patients Coinfected with Human Immunodeficiency Virus (HIV)Completed Study; data analyses ongoing18-125 YearsNIDDKImmunodeficiency
15-D-0051Characterization of Diseases with Salivary Gland InvolvementParticipants currently recruited/enrolled4-125 YearsNIDCRDisease
15-CC-0091Pulmonary Effects of Bronchial Segmental Endotoxin Instillation in HumansClinical hold/Recruitment or enrollment suspended18-45 YearsCC Lung
15-C-0205Phase II Randomized, Placebo-Controlled Trial of PROSTVAC (PSA-TRICOM) in Patients with Clinically Localized Prostate Cancer Undergoing Active SurveillanceCompleted Study; data analyses ongoing18-99 YearsNCI Lung
15-C-0157Phase I/II Trial of Vandetanib in Combination with Metformin in Subjects with HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell CarcinomaCompleted Study; data analyses ongoing18-125 YearsNCI Disease
15-C-0150A Phase I/II Trial of Topotecan with VX-970 (M6620), an ATR Kinase Inhibitor in Small Cell CancersNo longer recruiting/follow-up only18-125 YearsNCI Lung
15-C-0145Phase I/II Study of the Anti-Programmed Death Ligand-1 Antibody Durvalumab (MEDI4736) in Combination with Olaparib and/or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal CancersParticipants currently recruited/enrolled18-125 YearsNCI Lung
15-C-0099A Phase 1, Open-Label, Dose-Escalation Study of SNX-5422 and Everolimus in Subjects with Neuroendocrine TumorsCompleted Study; data analyses ongoing18-100 YearsNCI Disease
15-AR-0144Studies of Dermatologic Diseases-Biospecimen Acquisition ProtocolParticipants currently recruited/enrolled2-125 YearsNIAMSDisease
15-AG-0123Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain FunctionCompleted Study; data analyses ongoing55-70 YearsNIA Disease
15-AG-0063The Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)Participants currently recruited/enrolled20-125 YearsNIA Disease
14-I-0185A Phase III Double-Blind Randomized Crossover Study of Plerixafor Versus G-CSF in the Treatment of Patients with WHIM Syndrome.Completed Study; data analyses ongoing10-75 YearsNIAIDImmunodeficiency
14-I-0091Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995Completed Study; data analyses ongoing3-125 YearsNIAIDDisease
14-I-0089A Retrospective and Cross-Sectional Analysis of Patients Treated for Severe Combined Immunodeficiency (SCID) Since January 1, 1968Enrolling by Invitation2-125 YearsNIAIDImmunodeficiency
14-I-0081A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subcutaneous Benralizumab (MEDI-563) in Reducing Eosinophilia in Subjects with Hypereosinophilic Syndrome (HES)No longer recruiting/follow-up only18-75 YearsNIAIDLung
14-I-0072A Prospective Natural History Study of Diagnosis, Treatment and Outcomes of Children with SCID DisordersCompleted Study; data analyses ongoing2-125 YearsNIAIDImmunodeficiency
14-I-0063An Open-Label, Proof-of-Concept Study to Evaluate the Safety and Efficacy of Dexpramipexole (KNS-760704) in Subjects with Hypereosinophilic SyndromeNo longer recruiting/follow-up only18-125 YearsNIAIDLung
14-I-0020Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine ModelsParticipants currently recruited/enrolled18-65 YearsNIAIDImmunodeficiency
14-I-0009Characterization and Management of Patients with HIV-1 Infection Who Experience Virologic Failure Despite Combination Antiretroviral TherapyCompleted Study; data analyses ongoing18-100 YearsNIAIDImmunodeficiency
14-HG-0071Clinical and Basic Investigations into Known and Suspected Congenital Disorders of GlycosylationParticipants currently recruited/enrolled1-80 YearsNHGRIDisease
14-H-0127Characterization of the Pathogenesis of Primary and Secondary Lymphatic DisordersParticipants currently recruited/enrolled2-90 YearsNHLBILung
14-CC-0027The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients with Interstitial Lung DiseaseParticipants currently recruited/enrolled21-80 YearsCC Lung
14-C-0105Tissue Procurement and Natural History Study of Patients with Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial TumorsParticipants currently recruited/enrolled18-125 YearsNCI Lung
14-C-0104A Phase II Study Using Autologous Young Tumor-Infiltrating Lymphocytes Derived from Patients with Non-Small Cell Lung Cancer Following Non-Myeloablative Lymphocyte Depleting Preparative RegimenParticipants currently recruited/enrolled18-70 YearsNCI Lung
14-AR-0200Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic VasculitisParticipants currently recruited/enrolled3-125 YearsNIAMSDisease
14-AA-0144Reliability Of The Human Brain ConnectomeParticipants currently recruited/enrolled18-125 YearsNIAAADisease
13-N-0188Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal DementiaCompleted Study; data analyses ongoing18-125 YearsNINDSDisease
13-N-0165Electrical Impedance Myography: Natural History Studies in Neuromuscular Disorders and Healthy VolunteersParticipants currently recruited/enrolled2-125 YearsNINDSDisease
13-N-0149An Evaluation of HIV-associated Neurocognitive Disorders (HAND) in Virologically Controlled PatientsParticipants currently recruited/enrolled18-125 YearsNINDSImmunodeficiency
13-N-0140Cerebrospinal Fluid Collection and Repository StorageParticipants currently recruited/enrolled2-125 YearsNINDSDisease
13-N-0135Pilot Study of Raltegravir, an Integrase Inhibitor, in Human T-Cell Lymphotrophic Virus-1(HTLV-1) Associated Myelopathy, Tropical Spastic Paraparesis (HAM/TSP)Completed Study; data analyses ongoing18-125 YearsNINDSImmunodeficiency
13-N-0017Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)Participants currently recruited/enrolled2-125 YearsNINDSImmunodeficiency
13-I-0177Natural History Study of the Complications Associated with Allogeneic Hematopoietic Stem Cell TransplantationsCompleted Study; data analyses ongoing2-125 YearsNIAIDDisease
13-I-0082Rituximab (Anti-CD20) for the Treatment of Subjects With Anticytokine Autoantibody-Associated DiseasesCompleted Study; data analyses ongoing18-125 YearsNIAIDDisease
13-I-0062A Double Blind Randomized Placebo Controlled Study Examining the Effects of a Non-Absorbable (Rifaximin) Antibiotic on the Chronic Immune Activation Observed In HIV-infected SubjectsCompleted Study; data analyses ongoing18-65 YearsNIAIDImmunodeficiency
13-HG-0053The NIH Mini Study: Metabolism, INfection and Immunity in Inborn Errors of Mitochondrial MetabolismParticipants currently recruited/enrolled2-125 YearsNHGRIDisease
13-H-0194Inflammatory Characterization of Known or Possible Cardiovascular DiseasesNo longer recruiting/follow-up only18-125 YearsNHLBIDisease
13-H-0116A Multicenter Safety Study of Unlicensed, Investigational Cryopreserved Cord Blood Units (CBUs) Manufactured by the National Cord Blood Program (NCBP) and Provided for Unrelated Hematopoietic Stem Cell Transplantation of Pediatric and Adult PatientsParticipants currently recruited/enrolled4-125 YearsNHLBIDisease
13-H-0065Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic Disease (PACI) InitiativeNo longer recruiting/follow-up only18-125 YearsNHLBIDisease
13-H-0059Longitudinal Observational Study of Severe AsthmaParticipants currently recruited/enrolled18-125 YearsNHLBILung
13-H-0051Bronchodilator Effects of Nebulized versus Inhaled Albuterol in Subjects with LymphangioleiomyomatosisParticipants currently recruited/enrolled18-125 YearsNHLBILung
13-EI-0072Microbiome and Ocular Inflammatory DiseaseCompleted Study; data analyses ongoing18-125 YearsNEI Disease
13-D-0033Diagnosis and Treatment of Patients in Need of Third Molar Removal and Oral Specimen AcquisitionParticipants currently recruited/enrolled16-50 YearsNIDCRDisease
13-D-0014Bacterial Arrangement in Supragingival BiofilmsCompleted Study; data analyses ongoing18-999 YearsNIDCRDisease
13-C-0202Tissue Procurement and Natural History Study of Patients with Malignant Mesothelioma and Other Mesothelin Expressing CancersParticipants currently recruited/enrolled2-125 YearsNCI Lung
13-C-0153A Phase II Trial of Enzalutamide in Combination with PSA-TRICOM in Patients with Non-Metastatic Castration Sensitive Prostate CancerCompleted Study; data analyses ongoing18-125 YearsNCI Disease
13-C-0105Molecular Profiling-based Assignment of Cancer Therapy for Patients With Advanced Solid TumorsCompleted Study; data analyses ongoing18-120 YearsNCI Lung
13-C-0016A Phase I Study of an Adenoviral Transduced Autologous Dendritic Cell Vaccine Expressing Human HER2/neu ECTM in Adults with Tumors with 1-3+ HER2/neu ExpressionCompleted Study; data analyses ongoing18-125 YearsNCI Lung
13-AR-0056Stopping Tumor Necrosis Factor-Alpha Inhibitors in Rheumatoid ArthritisCompleted Study; data analyses ongoing18-125 YearsNIAMSDisease
12-N-0095Clinical and Molecular Manifestations of Neuromuscular and Neurogenetic Disorders of ChildhoodParticipants currently recruited/enrolled0-125 YearsNINDSLung
12-HG-0181The Clinical Study of Patients with Sex Chromosome VariantsCompleted Study; data analyses ongoing18-125 YearsNHGRIDisease
12-HG-0022Inherited Diseases, Caregiving, and Social NetworksCompleted Study; data analyses ongoing18-125 YearsNHGRIDisease
12-H-0064A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other IndicationsParticipants currently recruited/enrolled4-75 YearsNHLBIDisease
12-EI-0203Natural History of ABCA4-Related RetinopathiesNo longer recruiting/follow-up only12-125 YearsNEI Disease
12-EI-0042NEI Intramural Biorepository for Retinal DiseasesParticipants currently recruited/enrolled2-125 YearsNEI Disease
12-E-0190The Role of Functionally Relevant Cyclooxygenase-2 (COX-2) Gene Single Nucleotide Polymorphisms - 765G>C and 8473T>C in Lymphocyte DifferentiationCompleted Study; data analyses ongoing18-150 YearsNIEHSDisease
12-E-0061The Role of the Functionally Relevant Single Nucleotide Polymorphisms CYP2J2 -50G>T (CYP2J2 7) and EPHX2 9846A>G (EPHX2 K55R) in Human Endothelial FunctionCompleted Study; data analyses ongoing18-65 YearsNIEHSDisease
12-CC-0211A Pilot Study of the Effect of Spironolactone Therapy on Exercise Capacity and Endothelial Dysfunction in Pulmonary Arterial HypertensionParticipants currently recruited/enrolled18-125 YearsCC Lung
12-C-0197A Randomized Phase 2 Single-Center Study of Pomalidomide for Chronic GvHDCompleted Study; data analyses ongoing18-75 YearsNCI Lung
12-C-0047A Phase I/II Study of the Safety, Pharmacokinetics and Efficacy of Pomalidomide (CC-4047) in the Treatment of Kaposi Sarcoma in Individuals With or Without HIVCompleted Study; data analyses ongoing18-125 YearsNCI Immunodeficiency
12-AR-0159Effects of Treatments on the Microbiome in Healthy Volunteers and Patients with Atopic DermatitisParticipants currently recruited/enrolled2-50 YearsNIAMSDisease
11-I-0183Screening for LID Clinical Studies Unit Healthy Volunteer ProtocolsParticipants currently recruited/enrolled18-65 YearsNIAIDDisease
11-I-0164VRC 500: Screening Volunteers for Clinical Trials of Investigational Products and Licensed Products Evaluated for Research PurposesParticipants currently recruited/enrolled18-125 YearsNIAIDDisease
11-I-0109Viral Infections in Healthy and Immunocompromised HostsParticipants currently recruited/enrolled0-125 YearsNIAIDDisease
11-I-0057Effect of Interferon Alpha 2b Intensification on HIV-1 Residual Viremia in Individuals Suppressed on Antiretroviral TherapyCompleted Study; data analyses ongoing18-65 YearsNIAIDImmunodeficiency
11-I-0007Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age with X-Linked Severe Combined ImmunodeficiencyClinical hold/Recruitment or enrollment suspended2-40 YearsNIAIDImmunodeficiency
11-HG-0218A Natural History Study of Patients with GNE Myopathy and GNE-Related DiseasesParticipants currently recruited/enrolled4-80 YearsNHGRIDisease
11-HG-0110Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora PopulationsEnrolling by Invitation18-125 YearsNHGRIDisease
11-H-0134A Pilot Study of a Thrombopoietin-Receptor Agonist (TPO-R Agonist), Eltrombopag, in Moderate Aplastic Anemia PatientsNo longer recruiting/follow-up only2-125 YearsNHLBIDisease
11-EI-0245Generation of Induced Pluripotent Stem (iPS) Cell Lines from Somatic Cells of Participants with Eye Diseases and from Somatic Cells of Matched ControlsParticipants currently recruited/enrolled1-125 YearsNEI Disease
11-E-0006The Role of TGF-Beta in Asthmatic Epithelial Cell Susceptibility to RSV InfectionCompleted Study; data analyses ongoing18-60 YearsNIEHSLung
11-CC-0152The Natural History of Liver Disease in a Cohort of Participants with Hepatitis B and/or Hepatitis C with or without HIV InfectionCompleted Study; data analyses ongoing18-99 YearsCC Immunodeficiency
11-CC-0120Stereophotogrammetry of the Torso in Healthy Individuals and Patients with Scoliosis, Chest Wall Deformations, or ObesityCompleted Study; data analyses ongoing2-125 YearsCC Disease
11-C-0247A Randomized Phase II Study of Tecemotide in Combination with Standard Androgen Deprivation Therapy and Radiation Therapy for untreated, intermediate and High Risk Prostate Cancer PatientsCompleted Study; data analyses ongoing18-100 YearsNCI Lung
11-C-0242Collection of Blood from Patients with Cancer, Other Tumors, or Tumor Predisposition Syndromes for Analysis of Genetic Differences in Drug DispositionParticipants currently recruited/enrolled3-125 YearsNCI Lung
11-C-0140A Phase I Study of Gemcitabine, Carboplatin and Lenalidomide (GCL) for Treatment of Patients with Advanced/Metastatic Urothelial Carcinoma (UC) and Other Solid TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Lung
11-C-0096Pilot Trial of Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic MalignanciesNo longer recruiting/follow-up only18-125 YearsNCI Lung
11-C-0034DICER1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History StudyParticipants currently recruited/enrolled0-125 YearsNCI Lung
10-I-0197Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious DiseasesParticipants currently recruited/enrolled2-99 YearsNIAIDDisease
10-I-0139Searching for Persistence of Infection in Lyme DiseaseCompleted Study; data analyses ongoing18-125 YearsNIAIDDisease
10-I-0014The Natural History of Severe Viral Infections and Characterization of Immune DefectsParticipants currently recruited/enrolled2-125 YearsNIAIDImmunodeficiency
10-HG-0065Whole Genome Medical Sequencing for Gene DiscoveryParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
10-H-0154Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-CellsParticipants currently recruited/enrolled4-80 YearsNHLBIDisease
10-EI-0140Genotype - phenotype Study of Patients with Plaquenil-induced Retinal ToxicityParticipants currently recruited/enrolled18-125 YearsNEI Disease
10-E-0134Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA DamageCompleted Study; data analyses ongoing18-100 YearsNIEHSDisease
10-E-0129Study of the Effect of Innate Immunity on the Inflammatory Response to EndotoxinParticipants currently recruited/enrolled18-125 YearsNIEHSDisease
10-CC-0217A Comparison of Methods for Assisting Needle Angle Selection During Image-Guided Tissue BiopsyCompleted Study; data analyses ongoing18-125 YearsCC Lung
10-CC-0149Comparing Expectorated and Induced Sputum and Pharyngeal Swabs for Cultures, AFB Smears, and Cytokines in Pulmonary Nontuberculous Mycobacterial InfectionCompleted Study; data analyses ongoing18-80 YearsCC Lung
10-C-0174Related and Unrelated Donor Hematopoietic Stem Cell Transplant for DOCK8 DeficiencyParticipants currently recruited/enrolled4-125 YearsNCI Immunodeficiency
10-C-0066A Study of Hairy Cell and other Leukemias with a Focus on Recombinant Immunotoxins for Cancer TreatmentParticipants currently recruited/enrolled18-125 YearsNCI Disease
10-C-0056A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and LymphomasCompleted Study; data analyses ongoing18-125 YearsNCI Disease
09-NR-0088Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation TherapyCompleted Study; data analyses ongoing18-125 YearsNINR Disease
09-N-0010Biomarkers of Risk of Parkinson DiseaseCompleted Study; data analyses ongoing18-70 YearsNINDSDisease
09-I-0126Pathogenesis and Genetic Basis of Physical Induced Urticarial SyndromesParticipants currently recruited/enrolled2-90 YearsNIAIDImmunodeficiency
09-I-0032Comprehensive Multimodal Analysis of Patients with Neuroimmunological Diseases of the CNSParticipants currently recruited/enrolled0-99 YearsNIAIDDisease
09-DK-0223Rituximab Plus Cyclosporine in Idiopathic Membranous NephropathyParticipants currently recruited/enrolled18-125 YearsNIDDKDisease
09-C-0005Randomized Trial of Cladribine (CdA) with Simultaneous or Delayed Rituximab to Eliminate Hairy Cell Leukemia Minimal Residual DiseaseParticipants currently recruited/enrolled18-125 YearsNCI Disease
08-HG-0059Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis PatientsParticipants currently recruited/enrolled2-125 YearsNHGRIImmunodeficiency
08-H-0186Safety and the Anti- Tumor Effects of Escalating Doses of Adoptively Infused Ex Vivo Expanded Autologous Natural Killer (NK) Cells Against Metastatic Cancers or Hematological Malignancies Sensitized to NK-TRAIL Cytotoxicity with BortezomibCompleted Study; data analyses ongoing18-70 YearsNHLBILung
08-EI-0102Screening Protocol for the Evaluation and Diagnosis of Potential Research ParticipantsParticipants currently recruited/enrolled2-125 YearsNEI Disease
08-EI-0031Visual Motor CoordinationParticipants currently recruited/enrolled18-125 YearsNEI Disease
08-CC-0133Response and Adaptation to Aerobic Exercise in Patients with Pulmonary Hypertension: Initial Studies for Establishing GuidelinesCompleted Study; data analyses ongoing21-82 YearsCC Lung
08-C-0079Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromatosis Type 1No longer recruiting/follow-up only0-125 YearsNCI Lung
07-E-0023Innate Immunity Signal Transduction in Human LeukocytesParticipants currently recruited/enrolled18-65 YearsNIEHSDisease
07-CH-0008Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) SecretionCompleted Study; data analyses ongoing18-85 YearsNICHDDisease
06-M-0214PET Measurement of Regional Rates of Cerebral Protein Synthesis in Subjects with Fragile X SyndromeCompleted Study; data analyses ongoing18-24 YearsNIMH Disease
06-H-0072Atorvastatin as a Disease Modifying Agent in Stage II and III Pulmonary Sarcoidosis: A Randomized, Double-Blind, Placebo-Controlled TrialCompleted Study; data analyses ongoing18-70 YearsNHLBILung
06-EI-0236National Ophthalmic Genotyping and Phenotyping Network Stage 1 - Creation of DNA Repository for Inherited Ophthalmic DiseasesNo longer recruiting/follow-up only2-125 YearsNEI Disease
06-CH-0011Natural History Study of Patients with Excess AndrogenParticipants currently recruited/enrolled0-99 YearsNICHDDisease
05-H-0242A Pilot Study of Alemtuzumab (Campath) in Patients with Relapsed or Refractory Severe Aplastic AnemiaCompleted Study; data analyses ongoing2-110 YearsNHLBILung
05-H-0130Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell TransplantsParticipants currently recruited/enrolled7-80 YearsNHLBILung
05-CC-0216Prospective Assessment of Functional Status, Psychosocial Adjustment, Health Related Quality of Life and the Symptom Experience in Patients Treated with Allogeneic Hematopoietic Stem Cell TransplantationCompleted Study; data analyses ongoing18-125 YearsCC Disease
05-CC-0041Endothelial Cell Dysfunction in Pulmonary Arterial Hypertension: Biomarkers, Mechanisms of Disease and Novel Therapeutic TargetsCompleted Study; data analyses ongoing18-125 YearsCC Lung
04-HG-0211Analysis of Specimens from Individuals with Pulmonary FibrosisParticipants currently recruited/enrolled18-125 YearsNHGRILung
04-H-0012Collection of Blood, Bone Marrow, Urine, and/or Tissue Samples from Patients with Solid Tumors, Hematological Malignancies or Non-Malignant Hematologic Disorders or HLA Compatible Family MembersParticipants currently recruited/enrolled2-125 YearsNHLBIDisease
04-E-0053Personalized Environment and Genes StudyParticipants currently recruited/enrolled18-130 YearsNIEHSDisease
04-CH-0077Investigations of Bone-Related Connective Tissue DisordersCompleted Study; data analyses ongoing0-70 YearsNICHDDisease
04-CC-0119Biomarkers and Protein Mass Expression Profiles in Bronchoalveolar Lavage from Patients with Lung InfiltratesParticipants currently recruited/enrolled3-99 YearsCC Lung
04-C-0281Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host DiseaseParticipants currently recruited/enrolled1-125 YearsNCI Immunodeficiency
04-C-0274Follow-Up Study of Subjects Previously Enrolled in Immunotherapy Studies Utilizing Gene Transfer or Other Immunotherapeutic AgentsParticipants currently recruited/enrolled18-125 YearsNCI Lung
03-I-0263VRC 200: A Multicenter Specimen Collection Protocol to Obtain Human Biological Samples for Research StudiesParticipants currently recruited/enrolled18-125 YearsNIAIDDisease
03-H-0280Disease Pathogenesis and Natural History of Lipid DisordersParticipants currently recruited/enrolled2-100 YearsNHLBIDisease
03-H-0105The Determination of Genetic Basis Of ImmunodeficiencyParticipants currently recruited/enrolled0-125 YearsNHLBIImmunodeficiency
03-E-0099Pathogenic Studies In Families With Twins Or Siblings Discordant For Systemic Rheumatic DisordersCompleted Study; data analyses ongoing2-125 YearsNIEHSDisease
03-C-0277Cell Harvest and Preparation for Surgery Branch Adoptive Cell Therapy ProtocolsEnrolling by Invitation18-125 YearsNCI Lung
03-AR-0173Studies of Natural History, Pathogenesis, and Outcomes in Autoimmune and Inflammatory Diseases Including Juvenile DermatomyositisParticipants currently recruited/enrolled2-125 YearsNIAMSDisease
03-AG-0325The Baltimore Longitudinal Study of Aging(BLSA)Participants currently recruited/enrolled20-125 YearsNIA Lung
02-N-0014Research Study of Specimens Obtained During Epilepsy SurgeryCompleted Study; data analyses ongoing4-125 YearsNINDSDisease
02-I-0147Genetic Studies of Chronic Active Epstein-Barr Virus InfectionParticipants currently recruited/enrolled1-125 YearsNIAIDDisease
02-I-0110Natural History of Anthrax: A Study of Primary Infected, Recovered, and Exposed (SPoRE) Individuals and Evaluation of AVA Vaccinated RecipientsParticipants currently recruited/enrolled3-125 YearsNIAIDLung
02-HG-0107Natural History of Glycosphingolipid Storage Disorders and Glycoprotein DisordersParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
02-H-0250A Phase I/II Study of HLA-matched Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation for Advanced Mycosis Fungoides/Sezary Syndrome Using Nonmyeloablative Conditioning with Campath-1HCompleted Study; data analyses ongoing18-125 YearsNHLBILung
02-C-0210Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Blood and Lymph Node MalignancyParticipants currently recruited/enrolled0-125 YearsNCI Disease
02-C-0179Biospecimen Acquisition from Human SubjectsParticipants currently recruited/enrolled18-125 YearsNCI Lung
02-C-0159Birt-Hogg-Dub(SqrRoot)(Copyright) Syndrome: Characterization of the FLCN Disease Gene and Predisposition to Renal Cancer, Cutaneous Fibrofolliculoma and Pulmonary CystsParticipants currently recruited/enrolled2-125 YearsNCI Lung
01-N-0206Phenotype/Genotype Correlations in Movement DisordersParticipants currently recruited/enrolled2-125 YearsNINDSDisease
01-N-0007Evaluation, Pathogenesis, and Treatment of Patients with or at Risk for Cerebrovascular Disease (A Natural History/Disease Pathogenesis Protocol)Participants currently recruited/enrolled18-125 YearsNINDSDisease
01-I-0238Host Response to Infection and Treatment in Leishmania Infection of HumansParticipants currently recruited/enrolled3-100 YearsNIAIDDisease
01-H-0122Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease TherapyParticipants currently recruited/enrolled18-45 YearsNHLBIDisease
01-H-0088Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients with Sickle Cell AnemiaCompleted Study; data analyses ongoing18-125 YearsNHLBILung
01-DK-N117Family Investigation of Nephropathy and Diabetes (F.I.N.D.)Clinical hold/Recruitment or enrollment suspended18-125 YearsNIDDKDisease
01-D-0184A Natural History Study of Bone and Mineral DisordersParticipants currently recruited/enrolled0-125 YearsNIDCRDisease
01-C-0030Short-Course EPOCH - Rituximab in Untreated CD-20+ HIV-Associated LymphomasNo longer recruiting/follow-up only18-125 YearsNCI Immunodeficiency
01-C-0009Breast Imaging Screening Studies in Women at High Genetic Risk of Breast Cancer: Annual Follow-up StudyCompleted Study; data analyses ongoing18-100 YearsNCI Disease
00-N-0043Clinical and Molecular Manifestations of Inherited Neurological DisordersParticipants currently recruited/enrolled2-125 YearsNINDSDisease
00-HG-0141Clinical, Biochemical, and Molecular Investigations into AlkaptonuriaParticipants currently recruited/enrolled2-125 YearsNHGRILung
00-H-0051Cutaneous Tumorigenesis in Patients with Tuberous SclerosisParticipants currently recruited/enrolled18-90 YearsNHLBILung
00-CH-0136A Trial of Pamidronate in Children with Osteogenesis ImperfectaCompleted Study; data analyses ongoing2-17 YearsNICHDLung
00-CH-0093Diagnosis, Pathophysiology, and Molecular Biology of Pheochromocytoma and ParagangliomaParticipants currently recruited/enrolled3-125 YearsNICHDDisease
00-C-0078Collection of Blood, Fluid, Bone Marrow, Tumor, or Tissue Samples from Patients with Cancer or Normal VolunteersParticipants currently recruited/enrolled18-125 YearsNCI Lung
99-I-0084Studies of Human Pneumocystis InfectionParticipants currently recruited/enrolled3-99 YearsNIAIDLung
99-H-0076Asthma Sample Collection ProtocolParticipants currently recruited/enrolled18-125 YearsNHLBILung
99-H-0050Non-Myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in High Risk Patients and in Patients with Debilitating Hematologic DiseasesCompleted Study; data analyses ongoing2-80 YearsNHLBIDisease
99-DK-0002Diabetes and Heart Disease Risk in BlacksParticipants currently recruited/enrolled18-70 YearsNIDDKDisease
99-C-0128Evaluation for NCI Surgery Branch Clinical Research ProtocolsParticipants currently recruited/enrolled18-125 YearsNCI Lung
99-C-0099Examination of Clinical and Laboratory Abnormalities in Patients with Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or TrichothiodystrophyParticipants currently recruited/enrolled0-125 YearsNCI Disease
98-CH-0081Clinical and Basic Investigations into Smith-Lemli-Opitz SyndromeCompleted Study; data analyses ongoing0-125 YearsNICHDLung
98-CC-0019Volunteer Scanning on MRParticipants currently recruited/enrolled18-125 YearsCC Disease
97-HG-0192Genetic Studies in the Amish and MennonitesCompleted Study; data analyses ongoing18-125 YearsNHGRIDisease
97-H-0041Screening Protocol for Subjects Being Evaluated for National Heart, Lung and Blood Institute (NHLBI) ProtocolsEnrolling by Invitation2-125 YearsNHLBILung
97-C-0147Collection of Serum and Tissue Samples from Patients with Biopsy-Proved or Suspected Malignant DiseasesParticipants currently recruited/enrolled2-125 YearsNCI Disease
96-AR-0102Evaluation and Treatment of Subjects with Dermatologic DiseasesParticipants currently recruited/enrolled0-125 YearsNIAMSDisease
96-AR-0097The Acquisition of Blood and Skin Samples from Patient Volunteers to Support Research Activities on Dermatologic and Other DiseasesNo longer recruiting/follow-up only18-125 YearsNIAMSDisease
95-I-0027Virologic and Immunologic Evaluation of Lymph Node, Tonsillar and Intestinal Biopsies, and Bronchoalveolar Lavage FluidParticipants currently recruited/enrolled18-125 YearsNIAIDLung
95-HG-0193Clinical and Basic Investigations into Hermansky-Pudlak SyndromeParticipants currently recruited/enrolled0-125 YearsNHGRILung
95-H-0186Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)Participants currently recruited/enrolled16-125 YearsNHLBILung
95-CH-0059Definition of the Genotype and Clinical Phenotype of Primary Pigmented Nodular Adrenocortical Disease (PPNAD), Carney Complex, Peutz-Jeghers Syndrome and Related ConditionsCompleted Study; data analyses ongoing3-70 YearsNICHDDisease
94-HG-0105An Exploratory Study of the Genetics, Pathophysiology, and Natural History of Autoinflammatory DiseasesParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
94-E-0165Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory MyopathiesParticipants currently recruited/enrolled2-100 YearsNIEHSLung
94-DK-0127Pathogenesis of GlomerulosclerosisCompleted Study; data analyses ongoing2-125 YearsNIDDKDisease
94-C-0074Treatment and Natural History Study of Lymphomatoid GranulomatosisParticipants currently recruited/enrolled12-125 YearsNCI Lung
93-I-0086Evaluation and Long-Term Follow-Up of Patients with Acute or Chronic Inflammatory DisordersEnrolling by Invitation2-125 YearsNIAIDDisease
92-I-0125A Study of Viral Burden in Peripheral Blood Versus Lymphoid and Bone Marrow Tissue in HIV-Infected IndividualsParticipants currently recruited/enrolled18-125 YearsNIAIDImmunodeficiency
92-DK-0156Studies of Immunologically-Mediated Kidney DiseasesParticipants currently recruited/enrolled10-125 YearsNIDDKDisease
91-I-0140Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in HIV-Infected and HIV-Uninfected VolunteersParticipants currently recruited/enrolled18-125 YearsNIAIDDisease
91-DK-0214Evaluation of Patients with Liver DiseaseParticipants currently recruited/enrolled2-125 YearsNIDDKDisease
90-CC-0168A Rigid Body Database on Human MovementParticipants currently recruited/enrolled0-125 YearsCC Disease
89-N-0045Evaluation of Progression in Multiple Sclerosis by Magnetic Resonance Imaging (MRI)Participants currently recruited/enrolled18-125 YearsNINDSDisease
82-I-0183A Natural History Study of the Immune Regulation of Idiopathic Inflammatory Bowel Diseases: Crohn's Disease, Ulcerative Colitis, and Other Inflammatory Conditions of the GutParticipants currently recruited/enrolled0-75 YearsNIAIDDisease
79-H-0100Teaching Protocol for the Evaluation of Plasma LipoproteinsNo longer recruiting/follow-up only2-99 YearsNHLBIDisease
78-I-0023Diagnosis and Management of Inflammatory and Infectious DiseasesParticipants currently recruited/enrolled3-125 YearsNIAIDDisease
76-HG-0238Diagnosis and Treatment of Patients with Inborn Errors of Metabolism or Other Genetic DisordersParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
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