National Heart, Lung and Blood Institute (NHLBI)s

National Heart, Lung and Blood Institute (NHLBI)

141 Protocols (81 Active Accrual of new subjects, 60 Follow-up of previously enrolled subjects)

 001883-H:

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

 001742-H:

A Prospective Approach for the Early Detection of Infectious and Noninfectious Lung Diseases Following Allogeneic Hematopoietic Stem Cell Transplantation

 001667-H:

A Phase I/II Study of the JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure

 001635-H:

Non-myeloablative Phase I/II Haploidentical HCT Study for Patients with Sickle Cell Disease, Including Compromised Organ Function

 001621-H:

Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting with Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus

 001565-H:

A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Mitapivat in Subjects With Sickle Cell Disease

 001528-H:

A Phase I/II, Intra-Patient Dose-Escalation Study of the Selective GlyT1 Inhibitor, Bitopertin for Steroid-Refractory Diamond-Blackfan Anemia.

 001522-H:

A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Intravenous ZMA001 in Healthy Subjects

 001517-H:

Single Patient Study of JAK/STAT Inhibition in CNS Kohlmeier-Degos Disease

 001061-H:

Observational Study Investigating the Mechanistic Effects of Mitapivat in Subjects with Sickle Cell Disease

 000923-H:

Observational Study of Cardiac Arrhythmias During Treatment with BTK Inhibitors or Venetoclax

 000844-H:

Exploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients with Sickle Cell Disease (SCD)

 000829-H:

Controls and Healthy Vasculature Initiative

 000760-H:

Extension Study (extended access) of Syk-inhibition Using Fostamatinib to Treat Post-Transplant Immune-mediated Cytopenias

 000758-H:

A Phase II Study Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-Mediated Cytopenias

 000697-H:

U01 Cooperative Assessment of Late Effects for SCD Curative Therapies (COALESCE)

 000539-H:

Addition of JSP191 (c-kit antibody) to Non-myeloablative Hematopoietic Cell Transplantation For Sickle Cell Disease and Beta-Thalassemia

 000479-H:

Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

 000464-H:

Evaluation of Clonal Hematopoiesis in Patients with Sickle Cell Disease Receiving Curative Therapies

 000444-H:

Vaccine Responses in Patients with B Cell Malignancies

 000413-H:

Natural History study of CADASIL

 000387-H:

The Natural History of Acquired and Inherited Bone Marrow Failure Syndromes.

 000343-H:

Detection of T cell Somatic Mutations in Bone Marrow Failure Using Whole Exome or Targeted Sequencing

 000326-H:

A Phase 1, Dose Escalation, Safety and Tolerability Study of NX- 2127, a Bruton's Tyrosine Kinase (BTK) Degrader, in Adults with Relapsed/Refractory B-cell Malignancies

 000299-H:

Technical Development of Cardiovascular MRI

 000272-H:

Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults

 21-H-0027:

Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens into the Human Lung

 20-H-0158:

Natural History Study: Gene First Approach to Connective Tissue Disease

 20-H-0099:

Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors

 20-H-0049:

NHLBI DIR Cardiovascular Branch PK Papyrus Covered Stent Ethics Oversight of Humanitarian Use Device for Treatment of Acute Perforations of Native Coronary Arteries and Coronary Bypass Grafts in Vessels 2.5 to 5.0 mm in Diameter

 20-H-0033:

Early Initiation of Oral Therapy with Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

 20-H-0029:

An Intravenous, Open-Label, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers

 19-H-0139:

Investigation of the Natural Progression of Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance.

 19-H-0120:

Pilot Study for Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women

 19-H-0118:

Repeat Peripheral Blood Stem Cell Transplantation for Patients with Sickle Cell Disease or Beta-Thalassemia and Falling Donor Myeloid Chimerism Levels

 19-H-0111:

Early Clonal Dynamics During Venetoclax Treatment for Chronic Lymphocytic Leukemia (CLL)

 19-H-0057:

Multiple Patient Program for Lamprene (clofazimine) for the treatment of Non-Tuberculous Mycobacterial (NTM) Infections- CLAM320B2002M

 18-H-0146:

Genotype -Phenotype Correlation of PKLR Variants with Pyruvate Kinase, 2,3-Diphosphglycerate and ATP Activities in Red Blood Cells of Patients with Sickle Cell Disease

 18-H-0118:

Technical and Translational Development of Cardiovascular MRI (CMR)

 18-H-0108:

Vascular Disease Discovery Protocol

 18-H-0090:

Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH using Peripheral Blood Stem Cells and post-transplant Cyclophosphamide for GVHD prophylaxis

 18-H-0019:

Effect of Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

 18-H-0011:

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

 18-H-0004:

Low Dose Danazol for the Treatment of Telomere Related Diseases

 18-H-0003:

Discovery of Sirolimus Sensitive Biomarkers in Blood

 17-H-0162:

Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments: A Multi-Level, Community-Based Physical Activity Intervention

 17-H-0121:

Eltrombopag for Patients with Fanconi Anemia

 17-H-0095:

Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires

 17-H-0091:

Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn, Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells, to Expedite Engraftment and Improve Transplant Outcome

 17-H-0019:

A Randomized Trial of Sirolimus (Rapamune(R)) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

 16-H-0144:

Impact of Elastin Mediated Vascular Stiffness on End Organs

 16-H-0074:

Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank

 15-H-0190:

Human Biospecimen Procurement and Analysis to Support Translational Research to Identify Genetic Etiology and Disease Mechanism(s) in Rare Genetic Vascular/Cardiovascular Diseases

 14-H-0188:

Prospective Evaluation of Next Generation CT Reconstruction

 13-H-0183:

Cardiovascular Health and Needs Assessment in Washington D.C. - Development of a Community-Based Behavioral Weight Loss Intervention

 13-H-0116:

A Multicenter Safety Study of Unlicensed, Investigational Cryopreserved Cord Blood Units (CBUs) Manufactured by the National Cord Blood Program (NCBP) and Provided for Unrelated Hematopoietic Stem Cell Transplantation of Pediatric and Adult Patients

 13-H-0059:

Longitudinal Observational Study of Severe Asthma

 13-H-0051:

Bronchodilator Effects of Nebulized versus Inhaled Albuterol in Subjects with Lymphangioleiomyomatosis

 12-H-0150:

Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

 12-H-0141:

Prospective Evaluation of New Techniques in Radiation Reduction for Cardiovascular Computed Tomographic Angiography

 12-H-0064:

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications

 10-H-0168:

Submission of Autologous and Related Allogeneic Hematopoietic Stem Cell Transplant Data to the Center for International Blood and Marrow Transplant Research (CIBMTR) and the National Marrow Donor Program (NMDP)

 10-H-0154:

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

 10-H-0126:

Cardiovascular Disease Discovery Protocol

 09-H-0172:

Natural History of Bronchiectasis

 08-H-0105:

Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

 07-H-0142:

Research Respiratory Tract Procedures

 07-H-0113:

Procurement and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples from Healthy Volunteers to Support Clinical and Translational Research Projects in the NHLBI

 05-H-0130:

Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell Transplants

 04-H-0161:

Studies of the Natural History of Sickle Cell Disease

 04-H-0012:

Collection of Blood, Bone Marrow, Urine, and/or Tissue Samples from Patients with Solid Tumors, Hematological Malignancies or Non-Malignant Hematologic Disorders or HLA Compatible Family Members

 03-H-0280:

Disease Pathogenesis and Natural History of Lipid Disorders

 03-H-0105:

The Determination of Genetic Basis Of Immunodeficiency

 03-H-0015:

Human Specimen Collection to Support Basic and Clinical Research

 01-H-0122:

Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease Therapy

 00-H-0051:

Cutaneous Tumorigenesis in Patients with Tuberous Sclerosis

 99-H-0076:

Asthma Sample Collection Protocol

 97-H-0041:

Screening Protocol for Subjects Being Evaluated for National Heart, Lung and Blood Institute (NHLBI) Protocols

 96-H-0100:

Role of Genetic Factors in the Pathogenesis of Lung Disease

 96-H-0049:

Use of Granulocyte Colony Stimulating Factor (G-CSF) Mobilized Leukapheresis Collections from Healthy Volunteers to Develop Improved Methods of Stem Cell and Lymphocyte Selection for Allogeneic Transplantation

 95-H-0186:

Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)

 001619-H:

A Phase I Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects with Stable Sickle Cell Disease

 000556-H:

NHLBI-Emory Advanced Cardiac CT Reconstruction

 000149-H:

Pilot Study to Explore the Anti-Inflammatory Effects of Time-Restricted Feeding

 000110-H:

A Phase II Study Evaluating Fostamatinib for Hospitalized Adults with COVID-19

 000093-H:

Retrospective Study of Patients Long-Term Survival of Obstructive Hypertrophis Cardiomyopathy (HCM)

 000049-H:

Evaluation of the Safety,Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects with Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

 20-H-0141:

Long-term Follow-up of Subjects With Sickle Cell Disease Treated With Ex Vivo Gene Therapy Using Autologous Hematopoietic Stem Cells Transduced With a Lentiviral Vector

 20-H-0068:

Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait

 20-H-0044:

Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis

 20-H-0021:

Treatment of Refractory Diamond-Blackfan Anemia with Eltrombopag

 20-H-0016:

Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

 19-H-0100:

Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy

 19-H-0097:

A Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Multiple Oral Doses of AG-348 in Subjects with Stable Sickle Cell Disease

 19-H-0088:

NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study

 19-H-0001:

Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) Patients that are Treatment Na(SqrRoot) ve or Receiving Bruton s-tyrosine Kinase Inhibitor (BTK-I) Therapy

 18-H-0012:

A Phase I Study of HERV-E TCR Transduced Autologous T Cells in Patients with Metastatic Clear Cell Renal Cell Carcinoma

 17-H-0146:

Prospective Multicenter Registry On Radiation Dose Estimates of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)

 17-H-0124:

Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patients Using Plerixafor

 17-H-0118:

A Phase II Study Of Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

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