National Heart, Lung and Blood Institute (NHLBI)s

National Heart, Lung and Blood Institute (NHLBI)

171 Protocols (87 Active Accrual of new subjects, 84 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 19-H-0100:
Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy

* 19-H-0057:
Multiple Patient Program for Lamprene (clofazimine) for the Treatment of Non-Tuberculous Mycobacterial (NTM) Infections -CLAM320B2002M

* 19-H-0034:
Exploratory Study of Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome

* 19-H-0001:
Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) Patients that are Treatment Naive or Receiving Bruton s-Tyrosine Kinase Inhibitor (BTK-I) Therapy

* 18-H-0146:
Genotype -Phenotype Correlation of PKLR Variants with Pyruvate Kinase, 2,3-Diphosphglycerate and ATP Activities in Red Blood Cells of Patients with Sickle Cell Disease

* 18-H-0145:
Response to the HEPLISAV-B Hepatitis B Vaccine in Chronic Lymphocytic Leukemia (CLL) Patients that are Treatment Naive or Receiving Bruton s-tyrosine Kinase Inhibitor (BTK-I) Therapy

* 18-H-0118:
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging

* 18-H-0108:
Vascular Disease Discovery Protocol

* 18-H-0107:
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects

* 18-H-0090:
Haplo-identical Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using Peripheral Blood Stem Cells and Post-Transplant Cyclophosphomide for GVHD Prophylaxis

* 18-H-0019:
Effect of Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

* 18-H-0012:
A Phase I Study of HERV-E TCR Transduced Autologous T Cells in Patients with Metastatic Clear Cell Renal Cell Carcinoma

* 18-H-0011:
Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

* 18-H-0004:
Low Dose Danazol for the Treatment of Telomere Related Diseases

* 18-H-0003:
Discovery of Sirolimus Sensitive Biomarkers in Blood

* 17-H-0162:
Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments: A Multi-Level, Community-Based Physical Activity Intervention

* 17-H-0142:
Longterm Follow-up of Subjects With Hemoglobinopathies Treated With Ex Vivo Gene Therapy Using Autologous Hematopoietic Stem Cells Transduced With a Lentiviral Vector

* 17-H-0121:
Eltrombopag for Patients with Fanconi Anemia

* 17-H-0118:
A Phase II Study Of Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

* 17-H-0095:
Right Heart Catheterization Using MRI Fluoroscopy and Passive Guidewires

* 17-H-0091:
Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

* 17-H-0069:
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

* 17-H-0064:
Multicenter International Durability and Safety of Sirolimus Trial

* 17-H-0056:
Pathophysiology of Acute Pain in Patients with Sickle Cell Disease

* 17-H-0050:
Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults

* 17-H-0019:
A Randomized Trial of Sirolimus (Rapamune) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

* 16-H-0144:
Impact of Elastin Mediated Vascular Stiffness on End Organs

* 16-H-0089:
CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction

* 16-H-0074:
Williams Syndrome (WS) and Supravalvular Aortic Stenosis (SVAS) DNA and Tissue Bank

* 16-H-0019:
High Image Matrix CT Reconstruction

* 15-H-0190:
Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

* 15-H-0173:
Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults

* 15-H-0172:
A Pilot Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

* 15-H-0042:
Evaluation of the Effects of Niacin Therapy on Lipoprotein Composition and Function

* 15-H-0024:
Genes Involved in Lipid Disorders

* 15-H-0017:
Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis

* 14-H-0188:
Prospective Evaluation of Next Generation CT Reconstruction

* 14-H-0155:
A Phase 1 Study Evaluating Gene Therapy by Transplantation of Autologous CD34+ Stem Cells Transduced Ex Vivo with the LentiGlobinA BB305 Lentiviral Vector in Subjects with Severe Sickle Cell Disease

* 14-H-0127:
Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders

* 14-H-0077:
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia in Individuals with Higher Risk of Transplant Failure

* 13-H-0194:
Inflammatory Characterization of Known or Possible Cardiovascular Diseases

* 13-H-0183:
Cardiovascular Health and Needs Assessment in Washington D.C. - Development of a Community-Based Behavioral Weight Loss Intervention

* 13-H-0116:
A Multicenter Safety Study of Unlicensed, Investigational Cryopreserved Cord Blood Units (CBUs) Manufactured by the National Cord Blood Program (NCBP) and Provided for Unrelated Hematopoietic Stem Cell Transplantation of Pediatric and Adult Patients

* 13-H-0065:
Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic Disease (PACI) Initiative

* 13-H-0059:
Longitudinal Observational Study of Severe Asthma

* 13-H-0051:
Bronchodilator Effects of Nebulized Versus Inhaled Albuterol In Subjects With Lymphangioleiomyomatosis

* 12-H-0150:
Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

* 12-H-0141:
Prospective Evaluation of New Techniques in Radiation Reduction for Cardiovascular Computed Tomographic Angiography

* 12-H-0110:
An Open-label, Non-Randomized, Single-Arm Pilot Study to Evaluate the Effectiveness of Etidronate Treatment for Arterial Calcifications due to Deficiency in CD73 (ACDC)

* 12-H-0064:
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications

* 11-H-0064:
Extension Study (Extended Access) of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans

* 10-H-0168:
Submission of Autologous and Related Allogeneic Hematopoietic Stem Cell Transplant Data to the Center for International Blood and Marrow Transplant Research (CIBMTR) and the National Marrow Donor Program (NMDP)

* 10-H-0154:
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

* 10-H-0126:
Cardiovascular Disease Discovery Protocol

* 10-H-0097:
A Study of the Kinetics of Lymphoid Cells in Patients with Monoclonal B-Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL), Mantle Cell Lymphoma (MCL) and Healthy Volunteers.

* 09-H-0172:
Natural History of Bronchiectasis & Bronchiectasis Patient Registry

* 08-H-0186:
Safety and the Anti-Tumor Effects of Escalating Doses of Adoptively Infused Ex Vivo Expanded Autologous Natural Killer (NK) Cells Against Metastatic Cancers or Hematological Malignancies Sensitized to NK TRAIL Cytotoxicity with Bortezomib

* 08-H-0156:
Screening of Subjects to Determine Eligibility to Safely Participate in Blood Disorders Studies

* 08-H-0105:
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma(CLL/SLL), Lmphoplasmacytic Lymphoma(LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma(SMZL)

* 08-H-0046:
Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

* 07-H-0142:
Research Respiratory Tract Procedures

* 07-H-0113:
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples from Healthy Volunteers

* 07-H-0030:
Metabolic Regulation by Tumor Suppressor p53 in Li-Fraumeni Syndrome

* 07-H-0005:
Pilot Study of Topical Dexamethasone 0.01% Solution for Prevention of Oral Chronic Graft Versus Host Disease

* 05-H-0130:
Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell Transplants

* 04-H-0202:
Mutations in Genes Associated with Pentalogy of Cantrell

* 04-H-0161:
Studies of the Natural History of Sickle Cell Disease

* 04-H-0012:
Collection of Blood, Bone Marrow, Urine, and/or Tissue Samples from Patients with Solid Tumors, Hematological Malignancies or Non-Malignant Hematologic Disorders or HLA Compatible Family Members

* 03-H-0280:
Disease Pathogenesis and Natural History of Lipid Disorders

* 03-H-0170:
Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-Thalassemia

* 03-H-0168:
Natural History and Molecular Characterization of Benign Ethnic Neutropenia in Individuals of African Descent

* 03-H-0105:
The Determination of Genetic Basis Of Immunodeficiency

* 03-H-0015:
Human Specimen Collection to Support Basic and Clinical Research

* 02-H-0160:
Peripheral Blood Stem Cell Collection from Adult Volunteers

* 01-H-0122:
Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease Therapy

* 00-H-0051:
Cutaneous Tumorigenesis in Patients with Tuberous Sclerosis

* 99-H-0076:
Asthma Sample Collection Protocol

* 97-H-0061:
Evaluation and Treatment of Pulmonary Patients not Participating in Research (Training Protocol)

* 97-H-0041:
Screening Protocol for Subjects Being Evaluated for Hematology Branch Protocols

* 96-H-0100:
Role of Genetic Factors in the Pathogenesis of Lung Disease

* 96-H-0049:
Use of Granulocyte Colony Stimulating Factor (G-CSF) Mobilized Leukapheresis Collections from Healthy Volunteers to Develop Improved Methods of Stem Cell and Lymphocyte Selection for Allogeneic Transplantation

* 95-H-0186:
Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)

* 95-H-0047:
Diagnosis and Treatment of Patients with Heart and Vascular Disease (Training Protocol)

* 94-H-0010:
Evaluation, Treatment and Training Protocol for Patients with Bone Marrow Failure States, Isolated or Multilineage Cytopenias, Metastatic Solid Tumors, or Hematologic Malignancies

* 82-H-0032:
Comprehensive Evaluation of the Etiology and Pathogenesis of Chronic Lung Disease (Screening Protocol)

* 79-H-0100:
Teaching Protocol for the Evaluation of Plasma Lipoproteins

* 76-H-0051:
Lipoprotein Metabolism in Normal Volunteers and Hyperlipoproteinemic Patients

Active Follow-up, Protocols NOT Recruiting New Patients 

* 19-H-0088:
NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study

* 17-H-0169:
Treatment of an Individual Patient with Cystic Fibrosis and Mycobacterium Abscessus Lung Infection with Nitric Oxide Given Intermittently via Inhalation

* 17-H-0146:
Prospective Multicenter Registry On Radiation Dose Estimates of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTIONVI)

* 17-H-0124:
Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patients Using Plerixafor

* 17-H-0026:
Pembrolizumab and Decitabine for Refractory or Relapsed Acute Myeloid Leukemia

* 16-H-0174:
A Pilot Clinical Trial of COX-2 Inhibition in LAM and TSC

* 16-H-0132:
CADASIL Disease Discovery

* 16-H-0129:
Study to Evaluate the Effect of Nicotinamide Riboside on Immunity

* 16-H-0123:
Safety and Efficacy of Saracatinib in Subjects with Lymphangioleiomyomatosis (LAM) (SLAM-2)

* 16-H-0085:
Pilot Study to Evaluate the Effect of Fasting and Refeeding on T-Cell Fate

* 16-H-0063:
Williams Syndrome Skin and Vascular Elasticity Study (WS-SAVE Study)

* 15-H-0176:
A Pilot Study of Biomarkers for Personalized Early Assessment of Response During Salvage Chemotherapy in Patients with Relapsed Orrefractory Acute Myeloid Leukemia

* 15-H-0155:
Hereditary Parkinson's Disease Natural History Protocol

Next 71 Protocols