This study is NOT currently recruiting participants.
Number
OH99-DK-N019
Sponsoring Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruitment Detail
Type: Completed Study; data analyses ongoing Gender: Male & Female Min Age: 18 Years Max Age: 65 Years
Referral Letter Required
No
Population Exclusion(s)
Children
Keywords
Genetics; Fat Intake; Weight Control; Appetite Control; Natural History
Recruitment Keyword(s)
None
Condition(s)
Obesity; Overweight; Overnutrition
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Diabetes and Digestive and Kidney Diseases
In an effort to understand some of the influences on the high prevalence of obesity in the Pima Indians, the present study was designed to investigate eating behaviors and food preferences, most especially the preference for high fat foods, in sib-pairs of Pima Indians who have been previously genotyped in our genomic scan for loci linked to diabetes/obesity. Most specifically, we will utilize several questionnaires and methods of assessing eating behavior and the preference for high fat foods to create a food intake phenotype. In addition, we will study Caucasians so that comparisons can be made between these two groups. We will make these evaluations by assessing eating behavior, food preferences including usual fat intake and preferences for high fat foods, body image perceptions, and energy expenditure. It is hoped that the data gathered from this study will elucidate some of the risk factors for the development of obesity among the Pima Indians.
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Inclusion Criteria: 1. Healthy, as determined by medical history, physical examination, and laboratory tests. 2. 18-65 years old 3. Non-diabetic status Exclusion Criteria: 1. Hypo- or hyper-thyroid 2. Blood pressure greater than 160/95 3. Cardiovascular disease 4. Gallbladder disease 5. Alcohol and/or current use of drugs (more than 2 drinks per day and regular use of drugs such as amphetamines, cocaine, or heroin) 6. Psychiatric conditions or behavior that would be incompatible with safe and successful participation in this study, including claustrophobia and eating disorders such as anorexia or bulimia nervosa 8. Use of medications affecting metabolism and appetite 9. Pregnancy 10. Current use of nicotine products, including tobacco, electronic cigarettes, and nicotine replacement therapies Subjects may be excluded or withdrawn from the study if they have any conditions not specifically mentioned above that may interfere with the collection of the food intake. This includes such issues as not following study and unit policies and procedures, diagnosis of contraindications following admission, and development of illness/infection unrelated to the study. For example, volunteers who do not comply with the vending machine protocol (i.e., share food, do not record what they eat, eat outside of room, etc) may be withdrawn from the study.
1. Healthy, as determined by medical history, physical examination, and laboratory tests.
2. 18-65 years old
3. Non-diabetic status
Exclusion Criteria:
1. Hypo- or hyper-thyroid
2. Blood pressure greater than 160/95
3. Cardiovascular disease
4. Gallbladder disease
5. Alcohol and/or current use of drugs (more than 2 drinks per day and regular use of drugs such as amphetamines, cocaine, or heroin)
6. Psychiatric conditions or behavior that would be incompatible with safe and successful participation in this study, including claustrophobia and eating disorders such as anorexia or bulimia nervosa
8. Use of medications affecting metabolism and appetite
9. Pregnancy
10. Current use of nicotine products, including tobacco, electronic cigarettes, and nicotine replacement therapies
Subjects may be excluded or withdrawn from the study if they have any conditions not specifically mentioned above that may interfere with the collection of the food intake. This includes such issues as not following study and unit policies and procedures, diagnosis of contraindications following admission, and development of illness/infection unrelated to the study. For example, volunteers who do not comply with the vending machine protocol (i.e., share food, do not record what they eat, eat outside of room, etc) may be withdrawn from the study.
Principal Investigator
Referral Contact
For more information: