This study is NOT currently recruiting participants.
Number
OH82-DK-0136
Sponsoring Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruitment Detail
Type: Completed Study; data analyses ongoing Gender: Male & Female Min Age: 18 Max Age: 55
Referral Letter Required
No
Population Exclusion(s)
Children
Keywords
Insulin Sensitivity; Insulin Secretion; Glucose Tolerance; Adipose Tissue; Preadipocytes; Natural History
Recruitment Keyword(s)
None
Condition(s)
Weight Gain; Overweight; Insulin Resistance; Obesity; Diabetes Mellitus, Type 2
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Diabetes and Digestive and Kidney Diseases
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Volunteers for this study will be admitted to the clinical research ward where they will undergo several tests to determine body composition, oral and intravenous glucose tolerance and in vivo insulin action. In addition, in selected subjects, adipose and/or skeletal muscle tissue will be obtained by percutaneous biopsy for in vitro studies of gene expression and insulin action in these tissues. A transformed lymphocyte cell line will be established for each subject as a permanent source of DNA for genetic studies. Genetic markers for type 2 diabetes and insulin resistance will be sought by typing each individual at positional and functional candidate loci in the hopes of finding an association between these loci and obesity, insulin secretion, insulin resistance and/or type 2 diabetes.
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INCLUSION CRITERIA: Subjects from all racial and ethnic backgrounds will be invited to participate if they are: - Ages: 18-55 years old (up to 2200 participants) - Gender: male or female EXCLUSION CRITERIA: Subjects will be excluded who are: - Taking medication for a chronic illness. - Have any acute or chronic diseases or conditions not specifically mentioned that in the opinion of the provider may interfere with the study or decrease safety for participation will be considered exclusionary. - Women who currently pregnant or breastfeeding. - Positive for drug and/or nicotine use. All medications and alcohol consumption are to be stopped for two weeks prior to admission. A urine drug-screening test for drugs such as narcotics, marijuana, and barbiturates will be performed on everyone to exclude from the study people whose urine show active or recent drug use. A positive drug test could confound the results of the study in an unpredictable manner. The results of this test will become a part of the patient s medical records and may be released if requested (please see page 6 of the consent for details regarding medical records release).
Subjects from all racial and ethnic backgrounds will be invited to participate if they are:
- Ages: 18-55 years old (up to 2200 participants)
- Gender: male or female
EXCLUSION CRITERIA:
Subjects will be excluded who are:
- Taking medication for a chronic illness.
- Have any acute or chronic diseases or conditions not specifically mentioned that in the opinion of the provider may interfere with the study or decrease safety for participation will be considered exclusionary.
- Women who currently pregnant or breastfeeding.
- Positive for drug and/or nicotine use.
All medications and alcohol consumption are to be stopped for two weeks prior to admission. A urine drug-screening test for drugs such as narcotics, marijuana, and barbiturates will be performed on everyone to exclude from the study people whose urine show active or recent drug use. A positive drug test could confound the results of the study in an unpredictable manner. The results of this test will become a part of the patient s medical records and may be released if requested (please see page 6 of the consent for details regarding medical records release).
Principal Investigator
Referral Contact
For more information: