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Protocol Details

Genetic Studies of Stuttering

This study is NOT currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

97-DC-0057

Sponsoring Institute

National Institute on Deafness and Other Communication Disorders (NIDCD)

Recruitment Detail

Type: Completed Study; data analyses ongoing
Gender: Male & Female
Min Age: 6 Years
Max Age: N/A

Referral Letter Required

No

Population Exclusion(s)

None

Keywords

DNA Samples;
Stuttering;
DNA Testing;
Statistical Analysis;
Genetic Analysis;
Natural History

Recruitment Keyword(s)

Stuttering

Condition(s)

Stuttering

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute on Deafness and Other Communication Disorders

Stuttering is an abnormality in speech that affects the rhythm of speech. People who stutter know what they wish to say, but at the time are unable to say it because of involuntary repetition, unnecessary lengthening (prolongation), or early stopping (cessation). Stuttering is characterized by repetitions or prolongation of the first syllable, or silent prolongations, sometimes known as blocks.

Researcher intend on studying the genetic basis for stuttering. The goal of the study is to find the genes that help cause stuttering and determine regions of the human genetic make-up (genome) that are linked to stuttering.. To do this researchers will study the patterns of inheritance in families who have had members who stutter.

The study has two objectives.

The first objective is to develop a large collection of DNA samples from individuals in stuttering families, that will include both members that stutter and who do not stutter.

The second objective of the study will be to find out the basic combination of genes (genotype) making up all of the participants DNA. Once this is completed researchers hope to map out and find areas or regions of DNA that are linked to stuttering.

Genetic linkage is the initial step in positional cloning, and the cloning of genes which predispose individuals to stuttering is a long term goal of this research study.<TAB>

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Eligibility

INCLUSION CRITERIA:

- Individuals age 8 and older.

- Individuals age 6-8 with a family history of persistent stuttering

- Have stuttering that persists for a period of 6 months or more or are a family member of that person

-For the Phase 2 imaging studies, we will be enrolling up to 25 healthy volunteers to be controls

EXCLUSION CRITERIA:

- Stuttering only as a young child (before age 5) with no other family members who stutter

- Inability to provide informed consent or have a parent/guardian to provide consent

- Development of stuttering following trauma to the central nervous system.

- Chronic medical conditions that prevent informed consent or clear evaluation of stuttering, including stroke, dementia, and degenerative neurological disease.

- Inability to travel to the NIH Clinical Center for Phase 2


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Citations:

Not Provided

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Contacts:

Principal Investigator

Referral Contact

For more information:

Joshua Levy, M.D.
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIHBC 10 - CLINICAL CENTER BG RM 7N240B
10 CENTER DR
BETHESDA MD 20892
(240) 935-8305
joshua.levy@nih.gov

Joshua Levy, M.D.
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIHBC 10 - CLINICAL CENTER BG RM 7N240B
10 CENTER DR
BETHESDA MD 20892
(240) 935-8305
joshua.levy@nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1
ccopr@nih.gov

Clinical Trials Number:

NCT00001604

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