This study is currently recruiting participants.
Number
97-CH-0076
Sponsoring Institute
National Institute of Child Health and Human Development (NICHD)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 3 Years Max Age: 70 Years
Referral Letter Required
Yes
Population Exclusion(s)
None
Keywords
Developmental Defect; Oncogenesis; Evaluation and Management; Psychological; Cushing Disease; Natural History
Recruitment Keyword(s)
Condition(s)
Panhypopituitarism; Gigantism/Acromegaly; Prolactinoma; Cushing Disease
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Procedure/Surgery: MRI Procedure/Surgery: Tissue specimen collection
Supporting Site
National Institute of Child Health and Human Development
As a screening and training study, this protocol allows our Institute to admit children with tumors of the hypothalamic-pituitary unit to the pediatric endocrine clinics and wards of the NIH Clinical Center for the purposes of
(i)<TAB>training our fellows and students in the identification of genetic defects associated with pituitary tumor formation, and
(ii)<TAB>teaching our fellows and students the recognition, management and complications of pituitary tumors
As a research study, this protocol aims at
(i)<TAB>developing new clinical studies for the recognition and therapy of pituitary tumors; as an example, two new studies have emerged within the context of this protocol: (a) investigation of a new research magnetic resonance imaging (MRI) tool and its usefulness in the identification of pituitary tumors, and (b) investigation of the psychological effects of cortisol secretion in pediatric patients with Cushing disease. Continuation of this protocol will eventually lead to new, separate protocols that will address all aspects of diagnosis of pituitary tumors and their therapy in childhood.
(ii)<TAB>Identifying the genetic components of pituitary oncogenesis; those will be investigated by (a) studying the inheritance pattern of pituitary tumors in childhood and their possible association with other conditions in the families of the patients, and (ii) collecting tumor tissues and examining their molecular genetics. As with the clinical studies, the present protocol may help generate ideas for future studies on the treatment and clinical follow up of pediatric patients with tumors of the pituitary gland and, thus, lead to the development of better therapeutic regimens for these neoplasms.
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INCLUSION CRITERIA: 1. Stated willingness to comply with all study procedures and availability for the duration of the study 2. Male or female, aged 3 years to 70 years 3. Evidence for the existence of a tumor of the hypothalamic-pituitary unit, as indicated by previously obtained imaging studies or biochemical investigation of the hypothalamohypophyseal function. 4. Family members (any age) of patients with a family history of tumors and who will agree to participate in the DNA/linkage analysis study. 5. Member of a kindred suspected of having an inherited form of pituitary neoplasia, as evidenced by results of a patient enrolled in this protocol. 6. Ability of subject or Legally Authorized Representative (LAR)) to understand and the willingness to sign a written informed consent document. EXCLUSION CRITERIA: 1. Pregnancy.
1. Stated willingness to comply with all study procedures and availability for the duration of the study
2. Male or female, aged 3 years to 70 years
3. Evidence for the existence of a tumor of the hypothalamic-pituitary unit, as indicated by previously obtained imaging studies or biochemical investigation of the hypothalamohypophyseal function.
4. Family members (any age) of patients with a family history of tumors and who will agree to participate in the DNA/linkage analysis study.
5. Member of a kindred suspected of having an inherited form of pituitary neoplasia, as evidenced by results of a patient enrolled in this protocol.
6. Ability of subject or Legally Authorized Representative (LAR)) to understand and the willingness to sign a written informed consent document.
EXCLUSION CRITERIA:
1. Pregnancy.
Principal Investigator
Referral Contact
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