This study is currently recruiting participants.
Number
20-N-0105
Sponsoring Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 18 Years Max Age: 50 Years
Referral Letter Required
No
Population Exclusion(s)
Pregnant Women;Non-English Speaking;Children
Keywords
Healthy; Learning Consolidation; Brain; Natural History
Recruitment Keyword(s)
None
Condition(s)
Normal Physiology
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Neurological Disorders and Stroke
Training in a new motor skill often involves periods of active practice and periods of rest. During early motor skill learning, improvements in performance usually happen during the short rest periods between practice sessions. Researchers want to use improved imaging techniques to study the contributions of specific parts of the brain to how people learn and retain movement skills.
Objective:
To learn the part played by different layers in the brain in retaining a newly learned movement skill.
Eligibility:
Healthy, right-handed, English-speaking people age 18-50.
Design:
Participants will be screened with:
-Medical and neurological history
-Medicine review
-Physical exam
-Neurological exam.
Participants may have 2 magnetic resonance imaging (MRI) scans of the brain. During the MRI, they will lie in the scanner. The scanner makes noise. They will get earplugs.
Participants will have behavior testing. A specific order of keys will be displayed on a computer screen. Participants will practice typing the keys with their left hand 36 times (in 10-second blocks). They will repeat this test with a random order of keys.
Participants will see single numbers displayed one after the other on the computer screen. They will make single tap responses using the finger that corresponds with the number on the screen.
Participants will have up to 4 study sessions. Each session will take about 5 hours.
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INCLUSION CRITERIA: - Age 18-50 - English speaking - Right-hand dominance (>74 on Edinburgh Handedness Inventory) - Normal neurological examination - Willing and able to provide informed consent EXCLUSION CRITERIA: - HCPS-affiliated NIH staff (i.e. - staff from our section). - Current pregnancy - Current or past history of use of antiepileptic drugs - Contraindications for MRI (such as certain implants, metal fragments or devices in the body) as determined by the screening clinician - Severe or progressive neurological, psychological or medical condition
- Age 18-50
- English speaking
- Right-hand dominance (>74 on Edinburgh Handedness Inventory)
- Normal neurological examination
- Willing and able to provide informed consent
EXCLUSION CRITERIA:
- HCPS-affiliated NIH staff (i.e. - staff from our section).
- Current pregnancy
- Current or past history of use of antiepileptic drugs
- Contraindications for MRI (such as certain implants, metal fragments or devices in the body) as determined by the screening clinician
- Severe or progressive neurological, psychological or medical condition
Principal Investigator
Referral Contact
For more information: