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Protocol Details

Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

20-N-0105

Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18
Max Age: 50

Referral Letter Required

No

Population Exclusion(s)

Pregnant Women and Fetuses;
Non-English Speaking;
Children

Special Instructions

Currently Not Provided

Keywords

Stroke;
Healthy;
Learning Consolidation;
Brain

Recruitment Keyword(s)

None

Condition(s)

Normal Physiology

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Neurological Disorders and Stroke

Background:

Training in a new motor skill often involves periods of active practice and periods of rest. During early motor skill learning, improvements in performance usually happen during the short rest periods between practice sessions. Researchers want to use improved imaging techniques to study the contributions of specific parts of the brain to how people learn and retain movement skills.

Objective:

To learn the part played by different layers in the brain in retaining a newly learned movement skill.

Eligibility:

Healthy, right-handed, English-speaking people age 18-50.

Design:

Participants will be screened with:

-Medical and neurological history

-Medicine review

-Physical exam

-Neurological exam.

Participants may have 2 magnetic resonance imaging (MRI) scans of the brain. During the MRI, they will lie in the scanner. The scanner makes noise. They will get earplugs.

Participants will have behavior testing. A specific order of keys will be displayed on a computer screen. Participants will practice typing the keys with their left hand 36 times (in 10-second blocks). They will repeat this test with a random order of keys.

Participants will see single numbers displayed one after the other on the computer screen. They will make single tap responses using the finger that corresponds with the number on the screen.

Participants will have up to 4 study sessions. Each session will take about 5 hours.

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Eligibility

INCLUSION CRITERIA:

- Age 18-50

- English speaking

- Right-hand dominance (>74 on Edinburgh Handedness Inventory)

- Normal neurological examination

-Willing and able to provide informed consent

EXCLUSION CRITERIA:

- HCPS-affiliated NIH staff (i.e. - staff from our section).

- Current pregnancy

- Current or past history of use of antiepileptic drugs

- Contraindications for MRI (such as certain implants, metal fragments or devices in the body) as determined by the screening clinician

-Severe or progressive neurological, psychological or medical condition (as determined by screening clinician)


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Citations:

Not Provided

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Contacts:

Principal Investigator

Referral Contact

For more information:

Leonardo G. Cohen, M.D.
National Institute of Neurological Disorders and Stroke (NINDS)



Margaret K. Hayward, C.R.N.P.
National Institute of Neurological Disorders and Stroke (NINDS)
NIHBC 10 - CLINICAL CENTER BG RM 7D51B
10 CENTER DR
BETHESDA MD 20892
(301) 451-1335
mimi.hayward@nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010
PRPL@cc.nih.gov

Clinical Trials Number:

NCT04431011

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