Protocol Details
Mechanisms Underlying the Beneficial Effects of Naps on Motor Learning
This study is currently recruiting participants.
Summary
Number |
20-N-0060 |
Sponsoring Institute |
National Institute of Neurological Disorders and Stroke (NINDS) |
Recruitment Detail |
Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 80 Years |
Referral Letter Required |
No |
Population Exclusion(s) |
Children |
Keywords |
Motor Skill;
Sleep;
Neural Replay;
Natural History |
Recruitment Keyword(s) |
None |
Condition(s) |
Stroke |
Investigational Drug(s) |
None |
Investigational Device(s) |
None |
Intervention(s) |
Device: MRI system
Device: MEG system
|
Supporting Site |
National Institute of Neurological Disorders and Stroke |
Background:
Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows that daytime naps improve people s motor performance and memory retention. Researchers want to find out how daytime naps may contribute to learning and support consolidation of motor skill memories.
Objective:
To learn the role of memory replay during wakeful rest and sleep (naps) in retaining a newly learned skill.
Eligibility:
English-speaking adults ages 18 and older with chronic stroke, or healthy, right-handed, English-speaking adults ages 18-35 and 50-80
Design:
Participants will be screened with:
-medical history
-neurological history
-medicine review
-medical exam
-neurological exam.
Participants will have a magnetic resonance imaging (MRI) scan of the brain. For this, they will lie down in a scanner. The scanner makes loud noises, so they will wear earplugs. They will fill out an MRI screening form before each MRI.
Participants will also have magnetoencephalography (MEG). MEG maps brain activity. It does this by recording the magnetic fields produced by naturally occurring electrical currents in the brain. For MEG, participants will lie down in the MEG room. Their eye movements may be recorded by a video camera.
Participants will have behavior testing. They will practice typing random keys. Then they will repeatedly type a custom sequence that they see on a computer screen. Then they will take a 2-hour nap. Then they will type the same sequence again.
Participants will have no more than 4 visits at the NIH over 3 months. Visits will last 2-4 hours each.
Eligibility
HEALTHY VOLUNTEERS:
INCLUSION CRITERIA:
-Age 18-35 (Arm 1) or 50-80 (Arms 2).
-English speaking.
-Clear right-hand dominance (>74 on Edinburgh Handedness Inventory).
-Normal neurological examination as determined by the screening clinician.
EXCLUSION CRITERIA:
-HCPS affiliated NIH staff (i.e. - staff from our section).
-Current pregnancy.
-Contraindications for MRI or MEG.
-Use of sleep medications within 24 hours of Experimental Session participation.
-Severe or progressive neurological, psychological or medical condition as determined by the screening clinician.
STROKE PATIENTS:
INCLUSION CRITERIA:
-Age 18 or older
-Willing and able to provide consent
-Experienced a stroke 6 months ago or more that affected at least one of the upper extremities at time of stroke diagnosis
-Ability to perform the study task as assessed during physical examination
-English-speaking
EXCLUSION CRITERIA:
-HCPS-affiliated NIH staff (i.e. - staff from our section).
-Current pregnancy
-History of large stroke lesions in brainstem or cerebellum as determined by screening clinician
-Severe or progressive neurological disorder other than stroke (e.g., Parkinson s disease or multiple sclerosis) as determined by the screening clinician
-Uncontrolled heart, lung, kidney, gastrointestinal, metabolic, psychiatric, sleep, or endocrine disorders as determined by the screening clinician
-Contraindications for MRI or MEG.
Citations:
Not Provided
Contacts:
Clinical Trials Number:
NCT04312126