This study is currently recruiting participants.
Number
20-EI-0026
Sponsoring Institute
National Eye Institute (NEI)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 5 Years Max Age: 120 Years
Referral Letter Required
No
Population Exclusion(s)
None
Keywords
Cone-Rod Degeneration; Rod-Cone Degeneration; Eye; BCVA; OCT
Recruitment Keyword(s)
Condition(s)
Cone-Rod Degeneration; Rod-Cone Degeneration
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Diagnostic Test: VR Mobility Tool
Supporting Site
National Eye Institute
The retina is a thin layer of tissue at the back of the eye. Retinal disease usually reduces a person s mobility because it affects how he or she moves through familiar and unfamiliar environments. Researchers want to see if a virtual reality (VR) tool can provide an easier and more accurate way to assess mobility.
Objective:
To learn if researchers can track changes in mobility in people with retinal disease using a new VR tool.
Eligibility:
People aged 5 and older with retinal disease that affects their vision, and healthy volunteers.
Design:
Participants will have 2-3 clinic visits.
Participants will wear goggles or sit in front of a screen while sitting. Using a game controller, they will navigate through 4 obstacle courses presented in VR.
Participants will have a medical history exam. They will answer questions about their family history. They will fill out questionnaires about the vision and mobility issues they have in their daily lives.
Participants will have a complete eye exam. They will read letters from a chart. Their eye pressure will be measured. Their pupils may be dilated with eye drops. Pictures of their eye will be taken. Lights will be shined in their eyes.
Participants will take a visual field test. For this, they will look into a dome and press a button when they see a light.
Participants will have an electroretinogram. For this, they will sit in the dark with their eyes patched. Then their eyes will be numbed with eye drops and they will wear contact lenses while watching flashing lights.
Participants will have optical coherence tomography. This is a noninvasive procedure. It produces cross-sectional pictures of the retina.
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INCLUSION CRITERIA: To be eligible, the following inclusion criteria must be met. 1. Participant must be five years of age or older. 2. Participant (or legal guardian) must understand and sign the protocol's informed consent document. 3. Participant must be able to cooperate with the testing required for this study. 4. For healthy volunteers only: a. Participant must not have retinal disease in either eye. EXCLUSION CRITERIA: A participant is not eligible if any of the following exclusion criteria are present. 1. Participant is in another investigational study and actively receiving study therapy. 2. Participant is unable to comply with study procedures. STUDY EYE ELIGIBILITY CRITERIA: The participant must have at least one eye meeting all inclusion criteria. STUDY EYE INCLUSION CRITERIA: 1. Healthy Volunteers Only a. Study eye must have visual acuity of 20/20 or better, with or without correction (e.g., glasses or contact lens). 2. Participants with Retinal Disease Only Study eye must have retinal disease, defined as retinal dysfunction and/or degeneration as previously established by standard clinical methods including perimetry, ERG and imaging.
To be eligible, the following inclusion criteria must be met.
1. Participant must be five years of age or older.
2. Participant (or legal guardian) must understand and sign the protocol's informed consent document.
3. Participant must be able to cooperate with the testing required for this study.
4. For healthy volunteers only:
a. Participant must not have retinal disease in either eye.
EXCLUSION CRITERIA:
A participant is not eligible if any of the following exclusion criteria are present.
1. Participant is in another investigational study and actively receiving study therapy.
2. Participant is unable to comply with study procedures.
STUDY EYE ELIGIBILITY CRITERIA:
The participant must have at least one eye meeting all inclusion criteria.
STUDY EYE INCLUSION CRITERIA:
1. Healthy Volunteers Only
a. Study eye must have visual acuity of 20/20 or better, with or without correction (e.g., glasses or contact lens).
2. Participants with Retinal Disease Only
Study eye must have retinal disease, defined as retinal dysfunction and/or degeneration as previously established by standard clinical methods including perimetry, ERG and imaging.
Principal Investigator
Referral Contact
For more information: