This study is NOT currently recruiting participants.
Number
20-C-0103
Sponsoring Institute
National Cancer Institute (NCI)
Recruitment Detail
Type: No longer recruiting/follow-up only Gender: Male & Female Min Age: 18 Years Max Age: N/A
Referral Letter Required
No
Population Exclusion(s)
Children
Keywords
Pandemic; Coronavirus; SARS-CoV-2; Natural History
Recruitment Keyword(s)
None
Condition(s)
COVID-19
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Cancer Institute
People who get infected with COVID-19 have an unpredictable risk to worsen and die. This makes it hard to decide who can quarantine at home and who should be treated at a hospital. Researchers think the risk may be related to how a person s B and T cells respond to the virus. B and T cells are the major components of a person s immune response. B and T cells responding to the virus with a favorable pattern may lead to recovery, and this favorable pattern may be helpful to establish. If people in a vaccine trial get this same favorable pattern when responding to a vaccine, this may be a useful early signal that the vaccine will be successful.
Objective:
To examine how immune cells respond to COVID-19 infection.
Eligibility:
Adults ages 18 and older who have a confirmed or suspected COVID-19 infection or had COVID-19 in the past.
Also, healthy donors with no suspected COVID-19 infection
Design:
Participants will be screened with medical record review.
Participants will be tested with a research assay to determine who was infected with COVID-19 and who was not. This test will be used to understand research results, not to advise patients.
Participants with active infection must be isolated, usually in a hospital.
Other participants may give blood samples at NIH or at their local doctor s office or lab.
Participants may give blood samples up to three times a week for a total of ten times, and may also give blood samples after starting a vaccine trial.
Participants will be contacted by phone or email every 2 months for up to 2 years.
--Back to Top--
INCLUSION CRITERIA: -Individuals who meet one of the following groups: -- Patients with a confirmed or suspected diagnosis of COVID-19 infection, current or resolved; or, -- Normal donors. Note: For the purpose of this study, normal donors are those without a known current, past, or suspected COVID-19 infection; individuals may have other medical comorbidities or conditions. - At least 18 years of age - Ability of patient or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document EXCLUSION CRITERIA: Individuals with COVID-19 - Desire of the patient or normal donor not to submit samples, or medical contraindication to sending samples. EXCLUSION CRITERIA: Normal Donors - No Exclusions
-Individuals who meet one of the following groups:
-- Patients with a confirmed or suspected diagnosis of COVID-19 infection, current or resolved; or,
-- Normal donors. Note: For the purpose of this study, normal donors are those without a known current, past, or suspected COVID-19 infection; individuals may have other medical comorbidities or conditions.
- At least 18 years of age
- Ability of patient or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document
EXCLUSION CRITERIA: Individuals with COVID-19
- Desire of the patient or normal donor not to submit samples, or medical contraindication to sending samples.
EXCLUSION CRITERIA: Normal Donors
- No Exclusions
Principal Investigator
Referral Contact
For more information: