This study is NOT currently recruiting participants.
Number
19-N-0081
Sponsoring Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Completed Study; data analyses ongoing Gender: Male & Female Min Age: 18 Years Max Age: N/A
Referral Letter Required
Yes
Population Exclusion(s)
Children;Non-English Speaking
Keywords
Multiple Sclerosis; Non-contrast 3T Brain Scan; Differences Between MRI Scanners; Natural History
Recruitment Keyword(s)
None
Condition(s)
Multiple Sclerosis
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Neurological Disorders and Stroke
Magnetic resonance imaging (MRI) scans take detailed pictures of the body. These pictures can tell doctors about disease activity in multiple sclerosis (MS). More advanced MRI techniques are better at showing how the disease is progressing. However, they are used only in research settings. Researchers want to start using these newer approaches in order to speed progress in MS research.
Objective:
To study the differences between MRI scanners for assessing people with MS.
Eligibility:
People ages 18 to 60 years of age who have MS (recruiting). One (1) Healthy volunteer is also needed (healthy volunteer enrollment complete).
Design:
Participants will be screened with their medical history and a checklist to see if they are eligible.
Participants will have 4 MRIs at 4 separate sites within 3 months. One MRI will be at NIH. The others will be at sites in Philadelphia, Baltimore, and Boston.
Before each MRI, participants will have a physical exam. Women who arew having periods will have a blood or urine pregnancy test.
Participants will lie on a table. A coil will be placed around (but not touching) the head. The table will slowly slide the participant into the machine. Within the machine, radio waves will be transmitted and made into pictures of the body.
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INCLUSION CRITERIA: For MS patients: -Clinically and radiologically stable MS as per the 2017 McDonald criteria -Ambulatory -Able to travel -18 to 60 years of age -Fluent in English -Able to give informed consent For the healthy control subject: -Ambulatory -Able to travel -18 years or older -Fluent in English EXCLUSION CRITERIA: For MS patients: -Gadolinium-enhancing lesions (in the 6 months before recruitment) -Evidence of new lesions (in past 6 months before recruitment) -Not ambulatory -In clinical relapse -Major comorbidities -Steroids within 30 days of enrollment -Changes to disease modifying therapies (DMTs) within the 6 months prior to enrollment -Pregnancy For the healthy control subject: -History of neurological disease -Pregnancy
For MS patients:
-Clinically and radiologically stable MS as per the 2017 McDonald criteria
-Ambulatory
-Able to travel
-18 to 60 years of age
-Fluent in English
-Able to give informed consent
For the healthy control subject:
-18 years or older
EXCLUSION CRITERIA:
-Gadolinium-enhancing lesions (in the 6 months before recruitment)
-Evidence of new lesions (in past 6 months before recruitment)
-Not ambulatory
-In clinical relapse
-Major comorbidities
-Steroids within 30 days of enrollment
-Changes to disease modifying therapies (DMTs) within the 6 months prior to enrollment
-Pregnancy
-History of neurological disease
Principal Investigator
Referral Contact
For more information: