This study is NOT currently recruiting participants.
Number
19-H-0100
Sponsoring Institute
National Heart, Lung and Blood Institute (NHLBI)
Recruitment Detail
Type: Completed Study; data analyses ongoing Gender: Male & Female Min Age: 18 Years Max Age: N/A
Referral Letter Required
No
Population Exclusion(s)
Pregnant Women;Neonates;Fetuses;Children
Keywords
Sickle Nephropathy; Iothalamate; Cystatin-C; Natural History
Recruitment Keyword(s)
None
Condition(s)
Sickle Cell Disease
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Heart, Lung, and Blood Institute
Sickle cell disease is a common inherited blood disorder. Kidney disease is a major cause of problems in people with sickle cell disease. In order to identify kidney problems early and stop the progression of kidney disease, doctors need the most accurate tests to check kidney function. Researchers hope to understand more about how to test for kidney disease in people with sickle cell disease.
Objective:
To determine which of two different lab tests is the best to measure kidney function in adults with sickle cell disease.
Eligibility:
People 18 years and older who have sickle cell disease
Design:
Participants will be screened with a medical history and blood tests.
Participants will have up to 3 visits.
Participants will collect their urine in a special container over 24 hours.
At the first visit, participants will have blood tests. They will bring their container of urine to the visit. They will have an iothalamate test. For the test, they will get a catheter: a small tube will be inserted into a vein. A special contract agent will be injected into the vein. Blood will be collected over the next 4 hours to test kidney function.
Participants will return the next day for a second visit. They will have blood tests. They will have an MRI. For the MRI, they will like on a table that slides into a machine that takes pictures of the kidneys. They may have the MRI in a third visit.
--Back to Top--
INCLUSION CRITERIA: Known diagnosis of Sickle Cell Anemia (Hb SS or HbS-beta0-thal) >=18 years of age Willingness and capacity to provide written informed consent EXCLUSION CRITERIA: Pregnancy Uncontrolled/poorly controlled hypertension Diabetes Dialysis GFR <30 ml/min/1.73m2 HIV positive HepatitisC Hepatitis B Prior transplantation Uncontrolled infection or acute illness Chronic inflammatory disease (e.g. lupus, multiple sclerosis, rheumatoid arthritis) Allergy to iodine or iodinated contrast solutions Hydroxyurea initiation or dose adjustment <2mo prior Initiation of chronic transfusion therapy <2mo prior Antihypertensive medication initiation or dose adjustment <1mo prior Pain crisis in preceding 4weeks
Known diagnosis of Sickle Cell Anemia (Hb SS or HbS-beta0-thal) >=18 years of age
Willingness and capacity to provide written informed consent
EXCLUSION CRITERIA:
Pregnancy
Uncontrolled/poorly controlled hypertension
Diabetes
Dialysis
GFR <30 ml/min/1.73m2
HIV positive
HepatitisC
Hepatitis B
Prior transplantation
Uncontrolled infection or acute illness
Chronic inflammatory disease (e.g. lupus, multiple sclerosis, rheumatoid arthritis)
Allergy to iodine or iodinated contrast solutions
Hydroxyurea initiation or dose adjustment <2mo prior
Initiation of chronic transfusion therapy <2mo prior
Antihypertensive medication initiation or dose adjustment <1mo prior
Pain crisis in preceding 4weeks
Principal Investigator
Referral Contact
For more information: