This study is NOT currently recruiting participants.
Number
16-H-0085
Sponsoring Institute
National Heart, Lung and Blood Institute (NHLBI)
Recruitment Detail
Type: Completed Study; data analyses ongoing Gender: Male & Female Min Age: 21 Years Max Age: 37 Years
Referral Letter Required
Yes
Population Exclusion(s)
Children
Keywords
NLRP3 Inflammasome; Sirtuin 3; T-Cell Polarity; Caloric Restriction; Natural History
Recruitment Keyword(s)
None
Condition(s)
Asthma; Inflammation
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Heart, Lung, and Blood Institute
Researchers want to better understand the body s immune response to calorie restriction. To do this, they are asking healthy volunteers to fast for 24 hours. Researchers will test immune response before and after fasting.
Objectives:
To explore the benefits of calorie restriction on immune health.
Eligibility:
Healthy volunteers ages 21 to 37 with a body mass index between 22 and 29.
Design:
Participants will be screened with medical history, physical exam, and blood tests.
Participants will visit NIH after an overnight fast. Their baseline immune response will be taken. They will give blood and urine samples. Then they will be given breakfast. This visit will take about 2 hours.
Participants will fast (not eat or drink anything except water) for the next 24 hours. They will return to NIH the next morning. Their immune response will be taken. They will give blood and urine samples. Then they will be given breakfast. Their immune response will be taken 3 hours later. They will give a blood sample. This visit will take about 4 hours.
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INCLUSION CRITERIA: As this is a pilot study, the age-range and BMI range of subjects will be restricted to potentially reduce metabolic variables associated with a wide age- and BMI-range. -Males and females between the ages of 21 and 37 -BMI greater than or equal to 22 and less than 30 EXCLUSION CRITERIA: -Subjects with an acute or chronic illness as per history, on laboratory analysis or due to use of medications -Subjects taking vitamins or supplements or any medications, except oral contraceptives, within 4 weeks of participation into this study -BMI less than 22 or greater than or equal to 30 -Female subjects who are pregnant or lactating -Subjects who have donated blood or participated in another clinical trial involving blood draws in the last 8 weeks -Subjects who use nicotine products
As this is a pilot study, the age-range and BMI range of subjects will be restricted to potentially reduce metabolic variables associated with a wide age- and BMI-range.
-Males and females between the ages of 21 and 37
-BMI greater than or equal to 22 and less than 30
EXCLUSION CRITERIA:
-Subjects with an acute or chronic illness as per history, on laboratory analysis or due to use of medications
-Subjects taking vitamins or supplements or any medications, except oral contraceptives, within 4 weeks of participation into this study
-BMI less than 22 or greater than or equal to 30
-Female subjects who are pregnant or lactating
-Subjects who have donated blood or participated in another clinical trial involving blood draws in the last 8 weeks
-Subjects who use nicotine products
Principal Investigator
Referral Contact
For more information: