This study is currently recruiting participants.
Number
16-E-0006
Sponsoring Institute
National Institute of Environmental Health Sciences (NIEHS)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Female Min Age: 8 Years Max Age: 14 Years
Referral Letter Required
No
Population Exclusion(s)
Male
Keywords
Obesity; Puberty; Ultrasound; Pediatric; Natural History
Recruitment Keyword(s)
None
Condition(s)
Obesity; Puberty; Normal Physiology
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Environmental Health Sciences
Studies suggest that overweight girls may be developing breast tissue, and therefore starting puberty, earlier than normal weight girls. However, it is hard to distinguish breast tissue from fatty tissue. Researchers think that by using breast ultrasound, among other tests, they can do a better job of telling whether an overweight girl has breast tissue. This will help them understand if overweight girls are truly entering puberty before normal weight girls.
Objective:
To find out if overweight girls go through puberty earlier than normal weight girls.
Eligibility:
Healthy girls 8-14 years old who:
-Are normal weight or overweight
-Have some breast development
-Have not started their first period
Design:
Parents of participants will be screened over the phone.
Most participants will have 1 visit. However, they can choose to have multiple visits within 4 weeks. The visit will include:
-Physical exam that includes examination of the breasts and genital area
-Breast ultrasound: A small hand-held device will be passed back and forth over the chest. It uses sound waves to create a picture of the breast tissue.
-Pelvic ultrasound: A small, handheld device will be passed back and forth over the lower belly. It uses sound waves to create a picture of the ovaries.
-Urine and blood test
-A special x-ray called a DXA to measure the amount of fat in the body: The participant will lie still on a table while the x-ray takes pictures of the body.
X-ray of the hand: The picture will tell researchers how mature the participant s bones are.
Participants may be asked to come back 6 months later to repeat these tests.
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INCLUSION CRITERIA: - Girls without a chronic medical condition - Normal weight (BMI 5th-85th%) or overweight/obese (BMI > 85th%) - 8-14 years old - Some breast development - Pre-menarchal EXCLUSION CRITERIA: -Treated with medications that may affect reproductive hormones (e.g. birth control pills). -Pregnancy During the study, the PI s discretion may be used to determine final eligibility. The PI s discretion may be used at any point in the study (pre-screening, clinical/lab assessments, etc.) to ensure participants are not subjected to unnecessary procedures or visits.
- Girls without a chronic medical condition
- Normal weight (BMI 5th-85th%) or overweight/obese (BMI > 85th%)
- 8-14 years old
- Some breast development
- Pre-menarchal
EXCLUSION CRITERIA:
-Treated with medications that may affect reproductive hormones (e.g. birth control pills).
-Pregnancy
During the study, the PI s discretion may be used to determine final eligibility. The PI s discretion may be used at any point in the study (pre-screening, clinical/lab assessments, etc.) to ensure participants are not subjected to unnecessary procedures or visits.
Principal Investigator
Referral Contact
For more information: