This study is currently recruiting participants.
Number
15-EI-0020
Sponsoring Institute
National Eye Institute (NEI)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 12 Years Max Age: 120 Years
Referral Letter Required
No
Population Exclusion(s)
None
Keywords
Eye Disease; Natural History
Recruitment Keyword(s)
Condition(s)
Eye Diseases; Healthy Volunteers
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Eye Institute
- By the time diseases of the retina are detected, serious damage has often already been done. Researchers want to find better ways of viewing the retina. One way called adaptive optics may help detect problems earlier.
Objectives:
- To study if adaptive optics can help find better ways to diagnose, treat, and manage retinal diseases.
Eligibility:
- People over age 12 with an eye disease.
- Healthy volunteers over age 12.
Design:
- Participants will be screened with medical history and eye exams. These may include dilating pupils and taking pictures of the eyes.
- Participants will have 1 or more study visits. They will have:
- Medical and eye history.
- Questions about their medications.
- Eye exam including pupil dilation.
- Adaptive optics imaging. After dilation, participants sit still while looking into an adaptive optics instrument. They look at specific places and images are taken of their retina.
- They may also have:
- More images.
- Perimetry. Participants look into a lens and press a button when they see a light.
- Color vision tests.
- Electroretinogram. Participants will get numbing eye drops and special contact lenses. A small metal electrode will be put on their forehead. They will look at flashing lights and try not to blink.
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INCLUSION CRITERIA: Participants will be eligible if they: -Are 12 years of age or older. -Have the ability to cooperate with an eye exam and adaptive optics imaging. -Have the ability to understand and sign an informed consent or have a parent/legal guardian to do so if they are minor children. -Have an eye disease or are a healthy volunteer with a normal eye exam (no visually-significant eye findings on examination). EXCLUSION CRITERIA: Participants will not be eligible if: -They have a condition which prevents adequate images from being obtained (e.g. unstable fixation or media opacity). EXCLUSION CRITERIA FOR FLUORESCEIN AND/OR INDOCYANINE GREEN IMAGING Partaicipants are not eligible for fluorescein and/or indocyanine green imaging if they: -Are under 18 years of age. -For participants who will undergo fluorescein imaging have a history of adverse reaction to fluorescein. -For participants who will undergo indocyanine green imaging have a history of adverse reaction to indocyanine green dye, know or suspected allergies to iodine or shellfish.
Participants will be eligible if they:
-Are 12 years of age or older.
-Have the ability to cooperate with an eye exam and adaptive optics imaging.
-Have the ability to understand and sign an informed consent or have a parent/legal guardian to do so if they are minor children.
-Have an eye disease or are a healthy volunteer with a normal eye exam (no visually-significant eye findings on examination).
EXCLUSION CRITERIA:
Participants will not be eligible if:
-They have a condition which prevents adequate images from being obtained (e.g. unstable fixation or media opacity).
EXCLUSION CRITERIA FOR FLUORESCEIN AND/OR INDOCYANINE GREEN IMAGING
Partaicipants are not eligible for fluorescein and/or indocyanine green imaging if they:
-Are under 18 years of age.
-For participants who will undergo fluorescein imaging have a history of adverse reaction to fluorescein.
-For participants who will undergo indocyanine green imaging have a history of adverse reaction to indocyanine green dye, know or suspected allergies to iodine or shellfish.
Principal Investigator
Referral Contact
For more information: