This study is currently recruiting participants.
Number
13-N-0140
Sponsoring Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 2 Years Max Age: 110 Years
Referral Letter Required
No
Population Exclusion(s)
None
Keywords
Biomarkers; Immune Responses; Lumbar Puncture; Neurological Diseases; Novel Pathogens; Natural History
Recruitment Keyword(s)
Condition(s)
Nervous System Diseases
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Neurological Disorders and Stroke
- Cerebrospinal fluid (CSF) is the liquid around the brain and spinal cord. Many diseases can only be diagnosed by examining the CSF. A lumbar puncture is used to collect and test CSF. Once someone is already having a lumbar puncture, a small extra amount of CSF can be collected at the same time. This fluid can be used to study brain, nerve, and related health issues. Researchers want to collect CSF and blood samples from people who are scheduled to have a lumbar puncture.
Objectives:
- To collect cerebrospinal fluid and blood samples from individuals who are having a lumbar puncture.
Eligibility:
- Individuals between 2 and 100 years of age who are scheduled to have a lumbar puncture for clinical or research purposes.
Design:
- Participants will have a lumbar puncture for clinical or research purposes.
- During the procedure, an additional sample of CSF will be collected. They will also provide a blood sample, if one is not taken at the time of the procedure.
- Treatment will not be provided as part of this study.
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SUBJECT INCLUSION CRITERIA: -Subjects (patients and healthy volunteers) 2 years of age and older identified to undergo LP for research or for clinical care purposes at the NIH Clinical Center. SUBJECT EXCLUSION CRITERIA: -Subjects (patients and healthy volunteers) with the inability to provide informed consent either directly or via a legally authorized representative. Inclusion of Vulnerable Subjects - Research Involving Adults Who Are Or May Be Unable To Consent: -The risks to all subjects involved in this research project are no more than minimal risk as we are only collecting additional CSF and plasma during a LP procedure that is already being performed under a separate research protocol or as a clinically indicated procedure. At the time of the LP it will already be determined if the subject is able to give informed consent and if not a legally authorized representative will have been appointed who will decide if the additional CSF and plasma can be obtained from the individual.
-Subjects (patients and healthy volunteers) 2 years of age and older identified to undergo LP for research or for clinical care purposes at the NIH Clinical Center.
SUBJECT EXCLUSION CRITERIA:
-Subjects (patients and healthy volunteers) with the inability to provide informed consent either directly or via a legally authorized representative.
Inclusion of Vulnerable Subjects - Research Involving Adults Who Are Or May Be Unable To Consent:
-The risks to all subjects involved in this research project are no more than minimal risk as we are only collecting additional CSF and plasma during a LP procedure that is already being performed under a separate research protocol or as a clinically indicated procedure. At the time of the LP it will already be determined if the subject is able to give informed consent and if not a legally authorized representative will have been appointed who will decide if the additional CSF and plasma can be obtained from the individual.
Principal Investigator
Referral Contact
For more information: