This study is currently recruiting participants.
Number
08-EI-0102
Sponsoring Institute
National Eye Institute (NEI)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 2 Years Max Age: 100 Years
Referral Letter Required
No
Population Exclusion(s)
None
Keywords
Eye; Photograph; Retina
Recruitment Keyword(s)
Condition(s)
Eye Diseases
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Eye Institute
People of all ages with various eye conditions, including genetic conditions, eye movement disorders, inflammatory eye diseases, retinal diseases and external eye diseases, may be eligible for this study.
Participants undergo various tests and procedures to diagnose or evaluate their eye disease. The procedures may include the following:
-Personal and family medical history
-Physical examination and blood tests, including genetic testing.
-Eye examination with dilation to measure visual acuity and eye pressure and to examine the front and back parts of the eye.
-Questionnaire about vision and daily activities.
-Conjunctival swab or lacrimal bland biopsy, or both: A sample of cells from the eyes is collected by swabbing the surface of the eye or by surgically removing a small sample of the surface of the eye or tear gland.
-Electroretinogram to examine retinal function: The subject sits in the dark with his or her eyes patched for 30 minutes. The patches are removed, the surface of the eyes is numbed, and contact lenses that can sense signals from the retina are placed on the eyes. The subject then watches flashing lights.
-Fluorescein angiography to examine the blood vessels in the eye: A dye is injected into a vein in the arm. The dye travels through the veins to the blood vessels in the eyes. A camera takes pictures of the dye as it flows through the blood vessels.
-Optical coherence tomography to measure retinal thickness: A machine used to examine the eyes produces cross-sectional pictures of the retina.
-Microperimetry to test how sensitive different parts of the retina are to changing levels of light. The subject sits in front of a computer and presses a button when he or she sees a light on the screen.
-Oculography to record eye movements: Eye movements are measured by contact lenses or goggles that the subject wears while watching a series of spots on a computer screen.
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INCLUSION CRITERIA: Participants will be able to enroll if they: -Have a diagnosed ocular disease/disorder; OR -Potentially have an unusual, interesting, or unknown ocular condition that requires the establishment of a diagnosis; OR -Potentially participate as a disease-free control participant in an NEI clinical research study; OR -Are an unaffected first-degree relative of a participant with either a diagnosed or undiagnosed ocular disorder; AND -Have the ability to understand and sign an informed consent OR if they are minor children have a legal parent/guardian with the ability to do the same. -Adults with impaired capacity to consent must have a Legally Authorized Representative (LAR) who is able to provide informed consent. EXCLUSION CRITERIA: Participants will be unable to enroll if they: -Are unwilling or unable to cooperate with the study procedures. -Female participants of childbearing potential who are pregnant are not eligible for enrollment.
Participants will be able to enroll if they:
-Have a diagnosed ocular disease/disorder; OR
-Potentially have an unusual, interesting, or unknown ocular condition that requires the establishment of a diagnosis; OR
-Potentially participate as a disease-free control participant in an NEI clinical research study; OR
-Are an unaffected first-degree relative of a participant with either a diagnosed or undiagnosed ocular disorder; AND
-Have the ability to understand and sign an informed consent OR if they are minor children have a legal parent/guardian with the ability to do the same.
-Adults with impaired capacity to consent must have a Legally Authorized Representative (LAR) who is able to provide informed consent.
EXCLUSION CRITERIA:
Participants will be unable to enroll if they:
-Are unwilling or unable to cooperate with the study procedures.
-Female participants of childbearing potential who are pregnant are not eligible for enrollment.
Principal Investigator
Referral Contact
For more information: