This study is currently recruiting participants.
Number
04-E-0053
Sponsoring Institute
National Institute of Environmental Health Sciences (NIEHS)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 18 Years Max Age: 120 Years
Referral Letter Required
No
Population Exclusion(s)
Children
Keywords
Genotype; Phenotype; Environmental Factor; Single Nucleotide Polymorphism; Natural History
Recruitment Keyword(s)
None
Condition(s)
Diabetes; Heart Disease; Asthma
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Environmental Health Sciences
The Personalized Environment and Genes Study (PEGS) aims to provide a resource for environmental health translational research by examining gene-environment interactions in health and disease. PEGS is an extension of two previous efforts where it began as a pilot study, the Environmental Polymorphisms Study (EPS; IRB# 02E9004) and was approved subsequently as a full protocol titled the Environmental Polymorphisms Registry (EPR) (IRB #04-E-N0053 and transitioned to its current ID# 04-E-0053). The EPR was envisioned as a phenotype-by-genotype registry of participants who had donated DNA samples, and who had agreed to be contacted for follow-up clinical translational studies based on their DNA genotypes. At the time, the only information available was a participant s age, sex, race, and ethnicity. Further phenotyping of a participant and/or any biospecimens obtained were investigated during a follow-up translational clinical study on participants recruited based on their genotype (hence phenotype-by-genotype) and the PEGS was the first recruit-by- genotype study at the NIH. Following a period focused on recruiting approximately 15,000 participants to enable genotyping of rare (approximately 1% minor allele frequency) single nucleotide polymorphisms (SNPs), the PEGS Consortium Project was undertaken in 2010- 2011 to examine, using the DNA of nearly 4,000 participants, approximately 700 SNPs in approximately 80 environmental response genes that work in concert with environmental exposures to elicit a phenotype. Several clinical follow-up studies, genotype-phenotype association studies, and publications have resulted from the PEGS Consortium Project.
To expand phenotype information available to researchers, the Health and Exposure Questionnaire was administered between 2013-2014. In 2017, a more detailed Exposome Questionnaire which includes questions relating to the external and internal exposome was administered. This was an important resource through which to integrate exposures with genotype-phenotype association studies.
Whole genome sequencing has now been performed on approximately 4700 participants who were reconsented for this purpose, as indicated above. Questionnaire data was fully adjudicated and combined in a robust and searchable database. With the increased power of the data available, the project was renamed as the Personalized Environment and Genes Study (PEGS) and rolled out in Sept. 2021.
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INCLUSION CRITERIA In order to be eligible for participation in this study, an individual must meet all of the following criteria: -Male and female adults greater than or equal to 18 years of age -If female, must not be (self-reported as) pregnant. At the time of enrollment, a pregnancy test will only be done at the PI s discretion. -Able to understand and provide written informed consent -Able to come to the NIEHS Clinical Research Unit (CRU) for enrollment and study-related visits/procedures. EXCLUSION CRITERIA An individual who does not meet the inclusion criteria listed above is excluded from participation in this study.
In order to be eligible for participation in this study, an individual must meet all of the following criteria:
-Male and female adults greater than or equal to 18 years of age
-If female, must not be (self-reported as) pregnant. At the time of enrollment, a pregnancy test will only be done at the PI s discretion.
-Able to understand and provide written informed consent
-Able to come to the NIEHS Clinical Research Unit (CRU) for enrollment and study-related visits/procedures.
EXCLUSION CRITERIA
An individual who does not meet the inclusion criteria listed above is excluded from participation in this study.
Principal Investigator
Referral Contact
For more information: