This study is NOT currently recruiting participants.
Number
01-M-0185
Sponsoring Institute
National Institute of Mental Health (NIMH)
Recruitment Detail
Type: Completed Study; data analyses ongoing Gender: Male & Female Min Age: 18 Years Max Age: 50 Years
Referral Letter Required
No
Population Exclusion(s)
Children;Fetuses;Pregnant Women;Non-English Speaking
Keywords
Classical Conditioning; Fear Conditioning; Stress; Learning; Normal Volunteers
Recruitment Keyword(s)
Healthy Volunteer; Normal Control; Fear Conditioning
Condition(s)
Healthy Volunteers
Investigational Drug(s)
None
Investigational Device(s)
Intervention(s)
Device: Shock Device Device: Auditory Startle Device
Supporting Site
National Institute of Mental Health
When confronted with fearful or unpleasant events, people can develop fear of specific cues that were associated with these events as well as to the environmental context in which the events occurred via a process called classical conditioning. Classical conditioning has been used to model anxiety disorders, but the relationship between stress and anxiety and conditioned responses remains unclear. This study will examine the relationship between cued conditioning and context conditioning . This study will also explore the acquisition and retention of different types of motor, emotional, and cognitive associative processes during various tasks that range from mildly arousing to stressful.
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INCLUSION CRITERIA: -Males and females -Age 18-50 EXCLUSION CRITERIA: -Pregnancy -Any current ongoing medical illness -Current Axis I disorders -Past significant psychiatric disorders (e.g., psychotic disorders) according to Diagnostic and Statistical Manual (DSM)-IV -Current alcohol or substance abuse according to DSM-IV criteria -History of alcohol or substance dependence based on DSM-IV criteria within 6 months prior to screening -Current psychotropic medication use -Current or past organic central nervous system disorders, including but not limited to seizure disorder or neurological symptoms of the wrist and arms (e.g., carpal tunnel syndrome). The latter exclusion is for shock studies only. -Positive urine toxicology screen -Employees of National Institute of Mental Health (NIMH) or an immediate family member of a NIMH employee.
-Males and females
-Age 18-50
EXCLUSION CRITERIA:
-Pregnancy
-Any current ongoing medical illness
-Current Axis I disorders
-Past significant psychiatric disorders (e.g., psychotic disorders) according to Diagnostic and Statistical Manual (DSM)-IV
-Current alcohol or substance abuse according to DSM-IV criteria
-History of alcohol or substance dependence based on DSM-IV criteria within 6 months prior to screening
-Current psychotropic medication use
-Current or past organic central nervous system disorders, including but not limited to seizure disorder or neurological symptoms of the wrist and arms (e.g., carpal tunnel syndrome). The latter exclusion is for shock studies only.
-Positive urine toxicology screen
-Employees of National Institute of Mental Health (NIMH) or an immediate family member of a NIMH employee.
Principal Investigator
Referral Contact
For more information: