Protocol Details
Clinical and Molecular Analysis of Enlarged Vestibular Aqueducts
This study is NOT currently recruiting participants.
Summary
Number |
01-DC-0228 |
Sponsoring Institute |
National Institute on Deafness and Other Communication Disorders (NIDCD) |
Recruitment Detail |
Type: Completed Study; data analyses ongoing
Gender: Male & Female
Min Age: N/A
Max Age: 99 Years |
Referral Letter Required |
No |
Population Exclusion(s) |
Adults who are or may become unable to consent |
Keywords |
Genetics;
Deafness;
Genetic Markers;
Genetic Analysis;
GENETIC AGE;
Natural History |
Recruitment Keyword(s) |
Deafness;
Hearing Impairment;
Nonsyndromic Hereditary Hearing Impairment;
SNHL;
Inner Ear;
Enlarged Vestibular Aqueducts;
EVA |
Condition(s) |
Sensorineural Hearing Loss;
Cytomegalovirus Infection |
Investigational Drug(s) |
None |
Investigational Device(s) |
None |
Intervention(s) |
None |
Supporting Site |
National Institute on Deafness and Other Communication Disorders |
This study will try to identify and understand the genetic factors that lead to an inner ear malformation called "enlarged vestibular aqueducts", that can be associated with hearing loss.
Patients with sensorineural hearing loss with or without inner ear malformations and their parents and siblings may be eligible for this study. Participants and their immediate family members, may undergo some or all of the following tests and procedures:
- Medical and family history, including questions about hearing, balance and other ear-related issues, and review of medical records.
- Routine physical examination.
- Blood draw or buccal swab (brushing inside the cheek to collect cells) - Tissue is collected for DNA analysis to look for changes in genes that may be related to hearing loss.
- Hearing tests - The subject listens for tones emitted through a small earphone.
- Balance test (VEMP) to see if balance functions of the inner ear are associated with the hearing loss Electrodes will be placed behind your ear and at the base of your neck. From a reclining position, you will be asked to raise your head while clicking sounds are played into your ears. - Ultrasound tests - An inner ear malformation called EVA (enlargement of the vestibular aqueduct) indicates that a genetic disorder called Pendred syndrome may be the cause. Because thyroid abnormalities are also associated with Pendred syndrome, an ultrasound examination of the thyroid gland may be done.
- Computed tomography (CT) and magnetic resonance imaging (MRI) scans - These tests show the structure of the inner ear. For CT, the subject lies still for a short time while X-ray images are obtained. For MRI, the patient lies on a stretcher that is moved into a cylindrical machine with a strong magnetic field. The magnetic field and radio waves produce images of the inner ear. The radio waves cause loud thumping noises that can be muffled by the use of earplugs.
Eligibility
INCLUSION CRITERIA:
Subjects must have or be a family member of a participant with known or non-syndromic SNHL associated with EVA or have evidence of other findings that suggest that EVA might be part of a novel phenotype
There must be at least two participating affected family members with one exception: if there is only one participating affected family member, there must be genetic test results identifying only one pathogenic mutant allele of SLC26A4
Adults must be able to provide informed consent
Minors must have a parent or guardian able to provide consent
Age between 0-99.
EXCLUSION CRITERIA:
Subjects with known exposure to physical or chemical teratogens in utero that could account for their inner ear malformations such as thalidomide or radiation
Any hearing loss that is associated with symptoms which meet the criteria of already known syndromes, such as, branchio-oto-renal (BOR) syndrome, which comprises system malformations and branchial cleft abnormalities and is caused by heterozygous mutations in the EYA1 gene.
Previous genetic testing identifying two pathogenic mutant alleles of SLC26A4.
Prospective study subjects who are cognitively impaired and lack consent capacity, will not be enrolled.
Citations:
Mondini dysplasia and congenital cytomegalovirus infection
Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus
Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)
Contacts:
Clinical Trials Number:
NCT00023036