Protocol Details
A Natural History Study of Bone and Mineral Disorders
This study is currently recruiting participants.
Summary
Number | 01-D-0184 |
Sponsoring Institute | National Institute of Dental And Craniofacial Research (NIDCR) |
Recruitment Detail | Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 1 days
Max Age: 100 Years |
Referral Letter Required | No |
Population Exclusion(s) | None |
Keywords | Natural History;
skeletal diseases |
Recruitment Keyword(s) | Osteoporosis;
Dysplasia;
Osteomalacia;
Bone Diseases;
Skeletal Disease |
Condition(s) | Tumor Induced Osteomalcia;
Osteomalacia;
Familial Tumoral Calcinosis |
Investigational Drug(s) | None |
Investigational Device(s) | None |
Intervention(s) | None |
Supporting Site | National Institute of Dental and Craniofacial Research |
This study has four objectives: 1) to provide investigators the opportunity to study bone specimens from patients with various skeletal diseases; 2) to treat patients with skeletal diseases at the NIH; 3) to expose NIH trainees to certain skeletal diseases; and 4) to gain more knowledge about skeletal diseases and stimulate further study of bone biology.
Anyone with a disease that affects the skeleton may be eligible for this study.
All evaluations, tests, procedures and treatments given study participants are used in the standard care of skeletal diseases. No experimental evaluations or treatments are offered. Patient evaluations include a medical history, review of medical records and routine physical examination. Based on the findings, other procedures may be recommended, including blood tests, urine tests, and imaging tests, such as X-rays, bone densitometry, bone scan, computed tomography (CT) and magnetic resonance imaging (MRI).
Bone specimens from participants will be collected for research use. Specimens will be obtained from bone removed during a patient s planned surgical procedure performed for medical care, or patients may be requested to have a bone biopsy removal of a small piece of bone tissue as part of the patient evaluation procedure.
Eligibility
INCLUSION CRITERIA:
The study population will include participants with known or suspected bone disease and/or with a known or suspected disorder of mineral metabolism. To be eligible to participate in this study, an individual must meet all of the following criteria:
1. Age 1 day of life or older
2. Have a known or suspected bone disease, as demonstrated by any one of the following: a fracture, or abnormal bone findings on x-ray, CT scan, MRI, or bone densitometry, and/or a medical or family history consistent with or suggestive of a bone disease.
3. Have a known or suspected disorder of mineral metabolism, as demonstrated by any one of the following: laboratory measurement above or below the reference values for either blood or urine calcium, phosphorus, magnesium, parathyroid hormone or vitamin D, or other measures of mineral metabolism, and/or a medical or family history consistent with or suggestive of a disorder of mineral metabolism.
EXCLUSION CRITERIA:
1. Participants unwilling or unable to abide by procedures of protocol.
Citations:
Not Provided
Contacts:
Clinical Trials Number:
NCT00024804