Protocol Details
Platelet Volunteers, Longitudinal and Multi-omic Study
This study is currently recruiting participants.
Summary
Number |
002298-H |
Sponsoring Institute |
National Heart, Lung and Blood Institute (NHLBI) |
Recruitment Detail |
Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 100 Years |
Referral Letter Required |
No |
Population Exclusion(s) |
Children |
Keywords |
PLATELET FUNCTION;
Platelet biology |
Recruitment Keyword(s) |
None |
Condition(s) |
Thrombosis |
Investigational Drug(s) |
None |
Investigational Device(s) |
None |
Intervention(s) |
None |
Supporting Site |
National Heart, Lung, and Blood Institute |
Background:
Platelets are a type of blood cell that play a critical role in bleeding, forming blood clots, and healing. Researchers want to know more about platelets work in healthy people. They want to look at how platelets clump together, how blood clots, and how genes and proteins work. They also want to study how these processes change over time and how they are affected by factors such diet, exercise, weight, and new health problems.
Objective:
To study how platelets function in healthy people.
Eligibility:
Healthy people aged 18 years and older.
Design:
Researchers will review participants medical history. They will ask about the participant s family history and any drugs they take.
Participants will have a clinic visit once every 6 or 7 months for 10 years. Each visit will be 2 to 3 hours.
At each visit, participants will have several tests and procedures:
A physical exam, including vital signs. Hip and ankle circumference will be measured.
Urine collection.
Blood tests. About 10 tablespoons of blood will be drawn. Participants will be asked to fast for 10 hours and avoid drugs like aspirin or Advil for 7 days before each draw. Some of the blood may be used for gene studies. Some may be used to create stem cells for research. Stem cells are cells that can be used to make other types of cells.
Surveys and questionnaires. Participants will answer questions about habitual activity, diet, smoking, drugs and alcohol, sleep, illness, and other health issues. These surveys may be done online, via email, or by phone.
Eligibility
INCLUSION CRITERIA:
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
-Stated willingness to comply with all study procedures, including fasting at least 10 hours before each blood draw
-Stated willingness to refrain from aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) for 7 days prior to any visits
-Age >= 18 years
-In good general health as evidenced by self-reported medical history
EXCLUSION CRITERIA:
An individual who, by self-report, meets the following criteria will be excluded from participation in this study:
-Current pregnancy or lactation
-Active malignancies known, active known auto-immune disease, known major CVD (e.g., heart attack, stroke, venous thromboembolism, heart failure), severe bleeding history, on regular P2Y12 inhibitors or other antiplatelet treatments for a clinical reason, uncontrolled hypertension or diabetes
Citations:
Not Provided
Contacts:
Clinical Trials Number:
NCT07137429