Protocol Details

Characterizing the Brain Circuitry and Neural Activity Mediating Frustration

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

002073-M

Sponsoring Institute

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 55 Years

Referral Letter Required

No

Population Exclusion(s)

Adults who are or may become unable to consent;
Children;
Fetuses;
Neonates;
Non-English Speaking;
Pregnant Women

Keywords

Healthy volunteers, Frustration, Magnetoencephalography

Recruitment Keyword(s)

None

Condition(s)

Irritability

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

Other: Frustration task

Supporting Site

National Institute of Mental Health

Background:

Irritability can be defined as an unusually strong response to frustration; these responses may include severe temper outbursts and a constant grumpy mood. Irritability is a common symptom of many mental health disorders. Little is known about how the brain responds to frustration, and few treatments are available for this problem. Researchers want to know more about how the brain responds to frustration.

Objective:

To learn how the brain responds to frustration.

Eligibility:

Healthy adults aged 18 to 55 years. They must have been screened through studies 01-M-0254 or 17-M-0181.

Design:

Participants will have up to 3 study visits in 2 months. Each visit will last up to 4 hours.

Visit 1: Participants will be screened. They will have a physical exam. They will complete questionnaires about how often and how easily they get angry or grumpy. They will be trained to use a device that measures hand grip.

Visit 2: Participants will have a magnetic resonance imaging (MRI) scan. They will lie on a table that slides into a tube. Padding will hold their head still.

Visit 3: Participants will undergo magnetoencephalography (MEG). A cone with detectors will be lowered over their head while they are seated. The MEG will measure the magnetic fields in the participant s brain both while they are resting and while they are doing the frustration task. For the task, they will hold a grip device in each hand. They will use the devices to pick 1 of 2 doors on a computer screen. The task has 3 parts. The participant s face will be filmed during this task.

Eligibility

INCLUSION CRITERIA:

This study will include adult healthy volunteers.

-Age: 18-55

-Consent: can give consent

-Speak and read English

--The instruments have not been validated in other languages.

-At the NIH site, previously screened through other NIH protocols such as protocol 01-M-0254, 17-M-0181, and 93-M-0170 and determined eligible as healthy volunteers.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this

study:

-Any serious medical condition

--History, physical exam, or laboratory testing including drug abuse screen.

-Prescription and over-the-counter medications and dietary supplements with psychoactive properties (e.g., St. John's Wort, Melatonin, Valerian)

-Any condition that interferes with MRI or MEG**

--History

-Any current psychiatric diagnosis

--SCID-V, clinical assessment, or history.

-Pregnancy

--Pregnancy testing will be done before all MRIs.

-People who work on night shifts

--History

-Drug use

--Subjects with drug use or positive drug screen more than two years ago are eligible for participation.

-Need to wear eye glasses to work with computers*

--History

-Need to wear contact lenses to work with computers**,***

--History

-Dental retainer**

--Subjects wearing removable dental retainers are eligible for participation

*Eye glasses create artifacts in MEG and their rigid shape does not fit well in the MEG scanner. The MEG core has plastic optometry lenses that can be placed in paper frames. However, the paper frames need to be secured with tape which makes wearing them very uncomfortable, potentially promoting negative emotion and reducing the reliability of facial expression analysis.

**Only applies to the NIH site.

***Contact lenses create artifacts that interfere with eye-tracking.


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Contacts:

Principal Investigator

Referral Contact

For more information:

Zheng Li, Ph.D.
National Institute of Mental Health (NIMH)

(301) 594-2269
lizheng2@mail.nih.gov
Zheng Li, Ph.D.
National Institute of Mental Health (NIMH)

(301) 594-2269
lizheng2@mail.nih.gov
Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1
ccopr@nih.gov

Clinical Trials Number:

NCT06484088
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