Protocol Details
Speckle Plethysmography Pulse Transit Time as a Marker of Blood Pressure Changes
This study is NOT currently recruiting participants.
Summary
Number |
000849-CH |
Sponsoring Institute |
National Institute of Child Health and Human Development (NICHD) |
Recruitment Detail |
Type: Completed Study; data analyses ongoing
Gender: Male & Female
Min Age: 18 Years
Max Age: 99 Years |
Referral Letter Required |
No |
Population Exclusion(s) |
Pregnant Women;
Children |
Keywords |
Optical Technique;
Pulse Transit Time;
Pearson Correlation Coefficient;
Spg Waveform;
Signal Quality;
Natural History |
Recruitment Keyword(s) |
None |
Condition(s) |
Blood Pressure |
Investigational Drug(s) |
None |
Investigational Device(s) |
None |
Intervention(s) |
None |
Supporting Site |
National Institute of Child Health and Human Development |
Background:
Blood pressure is one of the key markers of cardiovascular health. High blood pressure, also called hypertension, can increase the risk of heart disease or stroke. Monitoring a person s blood pressure continuously over a 24-hour period at home is the best way to diagnose hypertension, but the equipment currently used to do it is cumbersome. This natural history study will test a new technique for monitoring blood pressure continuously over time.
Objective:
To test a new technique (speckle plethysmography) for measuring blood pressure in healthy adults.
Eligibility:
Healthy people aged 18 years and older.
Design:
Participants will come to the clinic a minimum of 2 times.
The screening visit will last up to 2 hours. Participants will have a physical exam. Their vital signs will be taken.
The clinical visit will last up to 1 hour. Participants will recline in a chair. Sensors to measure the activity of the heart will be placed on their chest. Different sensors will be placed on two fingers and one big toe. A device to measure blood pressure will be placed on one arm.
While wearing the sensors, participants will undergo 3 tests:
They will be asked to breathe slowly for 2 minutes.
They will be asked to solve a math problem.
They will immerse one hand or foot into an ice bath for up to 2 minutes.
Each test will be followed by a 5-minute recovery period.
Participants may elect to return for up to 3 more visits during the following week.
Eligibility
INCLUSION CRITERIA:
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- Male or female, aged 18 or greater.
- In good general health as evidenced by medical history and physical.
EXCLUSION CRITERIA:
An individual who meets any of the following criteria will be excluded from participation in this study:
- Any active cardiovascular or pulmonary disorders or use of vasoactive medications.
- History of aneurysm or stroke.
- Pregnant by history.
- History of fainting or seizures.
- An open cut, sore, or bone fracture on or near the hands or feet.
- Known retinopathy, intraocular lens implantation, or glaucoma.
- Any other condition that in the opinion of the investigator would place the participant at unacceptable risk.
Citations:
Not Provided
Contacts:
Clinical Trials Number:
NCT05554315