This study is currently recruiting participants.
Number
000827-AR
Sponsoring Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 2 Years Max Age: 120 Years
Referral Letter Required
No
Population Exclusion(s)
Adults who are or may become unable to consent;Pregnant Women
Keywords
Skin Conditions; Autoimmune Disease; Natural History
Recruitment Keyword(s)
None
Condition(s)
Hair Loss
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Alopecia is the loss of hair or lack of hair growth. It is often related to an immune disorder that disrupts the growth of hair. Hair loss can affect a person s physical and mental health. The causes of alopecia are not well understood. This natural history study will examine causes of alopecia so better treatments can be developed.
Objective:
To learn why some people have alopecia. This study will look at factors related to genes, the immune system, and the bacteria, viruses, and fungi that live on the skin.
Eligibility:
People aged 2 years and older with immune-mediated alopecia that affects 50% of their scalp hair.
Design:
Participants will have at least 1 visit to the clinic. Some will have follow-up visits once a year for up to 5 years. Each visit will last 2 to 4 hours.
Participants will have a physical exam. They will have blood drawn from a vein. They will answer questions about the medications they take, their allergies, and their family history. Photographs of their skin and scalp will be taken. Soft cotton swabs will be rubbed on their skin to pick up organisms that live there.
Two pieces of skin from the scalp will be cut away. The pieces will be no more than a quarter of an inch in size. The area will first be numbed with an injectable anesthetic. The wound will be closed with stitches or gel foam. The biopsy is optional in children younger than 12.
Participants will take a questionnaire about how hair loss affects their quality of life.
--Back to Top--
INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Stated willingness to comply with study procedures including skin biopsy of the scalp (except in those under the age of 12 years) and availability for the duration of the study 2. Willing to avoid using antibacterial cleansers for 1 week prior to sampling 3. Male or female, aged 2 years and older 4. Clinical Diagnosis of immune- mediated alopecia 5. Ability of subject or Parent/legal guardian to understand and the willingness to sign a written informed consent document. EXCLUSION CRITERIA: 1. Non-immune mediated alopecia including androgenetic alopecia, radiation induced alopecia, trauma induced alopecia, chemotherapy induced alopecia 2. Concomitant medical, surgical, or other conditions for which adequate facilities or funds are not available to support their care at the NIH. 3. Any other co-existing condition/circumstances that would make a subject unsuitable to participate in the study, as deemed by the investigators. 4. Pregnant women
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
1. Stated willingness to comply with study procedures including skin biopsy of the scalp (except in those under the age of 12 years) and availability for the duration of the study
2. Willing to avoid using antibacterial cleansers for 1 week prior to sampling
3. Male or female, aged 2 years and older
4. Clinical Diagnosis of immune- mediated alopecia
5. Ability of subject or Parent/legal guardian to understand and the willingness to sign a written informed consent document.
EXCLUSION CRITERIA:
1. Non-immune mediated alopecia including androgenetic alopecia, radiation induced alopecia, trauma induced alopecia, chemotherapy induced alopecia
2. Concomitant medical, surgical, or other conditions for which adequate facilities or funds are not available to support their care at the NIH.
3. Any other co-existing condition/circumstances that would make a subject unsuitable to participate in the study, as deemed by the investigators.
4. Pregnant women
Principal Investigator
Referral Contact
For more information: