NIH Clinical Center Search the Studies: Study Number, Study Title

Protocol Details

Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts




Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 100 Years

Referral Letter Required


Population Exclusion(s)

Non-English Speaking;


Healthy Adult;
Diffusion Tensor Imaging;
Natural History

Recruitment Keyword(s)



Normal Physiology

Investigational Drug(s)


Investigational Device(s)




Supporting Site

National Institute of Biomedical Imaging and BioengineeringNational Institute of Neurological Disorders and Stroke


Magnetic resonance imaging (MRI), which uses strong magnets to get images of structures inside the body, is a valuable tool in modern medicine. But researchers are always looking for ways to improve this technology. To better understand how to use MRI to diagnose problems, researchers need to collect more data from scans of healthy people.


To get MRI scans of healthy people to improve the measurements doctors can make from the images.


People aged 18 years or older in good general health.


Participants will be screened. They will have a physical exam focused on their nervous system. They will complete questionnaires.

Participants will have at least 1 MRI scan. The target of the scan may be the brain, liver, prostate, breast, or other body part. Before the scan, participants will remove any metallic objects. They will lie on a narrow table that moves into a long, narrow tube. They may have special pads placed around them to help them remain still.

Participants will hear loud noises during the scan. They will get earplugs or earmuffs to wear to muffle the sound. They can communicate with the MRI technician and will have an emergency button to squeeze at any time if they want the scan to stop. The scan will take up to 2 hours.

Some participants may be asked to perform tasks on a computer screen during the scan.

Participants may return for up to 5 scans in 3 months. Some may have as many as 30 MRI visits per year. They may remain in the study for up to 2 years.

--Back to Top--



In order to be eligible to participate in this study, an individual must meet all of the following criteria:

-Stated willingness to comply with all study procedures and availability for the duration of the study

-Male or female, aged 18 years of age and older

-In good general health as evidenced by medical history

-Ability of subject to understand and the willingness to sign a written informed consent document.

-Must have had a neurological physical exam as prescribed by NINDS policy. At the time of writing, this is required at least once every 2 years, and record of the exam should be in the medical record. This exam must be done prior to having MRI # 1. If deemed adequate by the Investigators, reports of examination by clinicians who are not Investigators on this study may be used. In addition, subjects must complete the most-recent version of the NMR safety screening form or NIH Radiology and IS MRI safety questionnaire when required at each visit.


An individual who meets any of the following criteria will be excluded from participation in this study:

-Has any metal implant or objects of unknown identity or composition, or if it s known to be non-compatible with MRI, such as pacemakers, medication pumps, aneurysm clips, metallic prosthesis (such as heart valves or cochlear implants), certain orthopedic implants (pins and rods), shrapnel, or small metal fragments in the eye;

-Has claustrophobia to a degree that would preclude lying comfortably in the scanner for the duration of the examination;

-Cannot lie comfortably for up to 120 minutes;

-Has hearing problems which would make it difficult to tolerate scanner noise;

-Subjects with tattoos or permanent eye liner; liner; will not be excluded, however, tattoos carry a small risk of heating and burns. Therefore, each tattoo will be considered on a case by case basis, taking into account the age of the tattoo and the location of the tattoo on the subject s body.

-Has medical health problems such as pulmonary or airway disease, heart failure, coronary artery disease, which would require physiological monitoring during the scan;

-History of any medical condition that could result in an emergency medical situation while undergoing the MRI scan;

-For >7T: Has a ferromagnetic dental crown or a bridge.

-Non-English speakers are excluded as it is important that volunteers understand the complex instructions required to undergo an MRI procedure, and there is no direct benefit to participants.

-Pregnant women:

--a) If a woman is pregnant at the time of enrollment, we will popstpone enrollment until she is no longer pregnant.

--Participants will not remain on the study should they have a positive pregnancy test at a study visit.

--Back to Top--


Walker L, Curry M, Nayak A, Lange N, Pierpaoli C; Brain Development Cooperative Group. A framework for the analysis of phantom data in multicenter diffusion tensor imaging studies. Hum Brain Mapp. 2013 Oct;34(10):2439-54. doi: 10.1002/hbm.22081. Epub 2012 Mar 28. PMID: 22461391; PMCID: PMC3458186.

Sadeghi N, Nayak A, Walker L, Okan Irfanoglu M, Albert PS, Pierpaoli C; Brain Development Cooperative Group. Analysis of the contribution of experimental bias, experimental noise, and inter-subject biological variability on the assessment of developmental trajectories in diffusion MRI studies of the brain. Neuroimage. 2015 Apr 1;109:480-92. doi: 10.1016/j.neuroimage.2014.12.084. Epub 2015 Jan 9. PMID: 25583609; PMCID: PMC4350793.

Pierpaoli C. Quantitative brain MRI. Top Magn Reson Imaging. 2010 Apr;21(2):63. doi: 10.1097/RMR.0b013e31821e56f8. PMID: 21613871; PMCID: PMC4819319.

--Back to Top--


Principal Investigator

Referral Contact

For more information:

Carlo E. Pierpaoli, M.D.
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
Building 13
Room 3W16
13 South Drive
Bethesda, Maryland 20892
(301) 402-2289

Whitney M. Spencer
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
Building 10
Room 2A23
10 Center Drive
Bethesda, Maryland 20892
(301) 402-6668

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1

Clinical Trials Number:


--Back to Top--