Protocol Details
Adaptive Optics Imaging of Outer Retinal Diseases
This study is currently recruiting participants.
Summary
Number | 000187-EI |
Sponsoring Institute | National Eye Institute (NEI) |
Recruitment Detail | Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 21 Years
Max Age: 120 Years |
Referral Letter Required | Yes |
Population Exclusion(s) | Adults who are or may become unable to consent;
Children |
Keywords | Diagnostic methods;
Biomarkers;
Clinical endpoints;
Retina images |
Recruitment Keyword(s) | None |
Condition(s) | Retinal diseases |
Investigational Drug(s) | None |
Investigational Device(s) | None |
Intervention(s) | None |
Supporting Site | National Eye Institute |
Background:
A new type of retinal imaging technology uses adaptive optics (AO). AO senses the way the eye distorts light and corrects imaging beams to allow very sharp pictures of the retina to be taken. AO could vastly aid in detecting and treating eye diseases. Researchers want to further study AO.
Objective:
To collect AO retinal images from participants with outer retinal diseases and healthy volunteers to develop new diagnostic methods, biomarkers, and clinical endpoints.
Eligibility:
Adults ages 21 and older who have an outer retinal disease or condition. Healthy volunteers are also needed.
Design:
Participants will be screened with a medical record review. They will have an eye exam that uses dilation drops. The exam will:
Test how well they see
Measure eye pressure, the thickness of their retina, their cornea, and the length of their eye
Look at the front of their eye to evaluate safety of dilation
Take pictures of the inside of their eye
Test their ability to detect different light levels. For this, they will sit in front of a computer screen and press a button when they see a light.
Participants may be removed from the study if their risk of reaction to the eye drops is high or if they have certain vision issues or a condition that prevents adequate imaging.
Participants will have AO imaging sessions. They will get dilation drops. They will sit, place their chin on a rest, and look into the imaging instrument. They will observe several lights. Beams of light will take images of their retina. They will get rest periods. Videos of their retina may be taken.
Participation will last up to 3 years.
Eligibility
INCLUSION CRITERIA:
Participants will be eligible if they:
1. Are 21 years of age or older,
2. Have the ability to cooperate with instructions during adaptive optics imaging (similar to instructions given during a clinical eye exam),
3. Have the ability to understand and sign an informed consent. (Non-English speaking participants will not be enrolled into the study), and
4. Have been diagnosed with outer retinal disease or condition (Cohort 2).
EXCLUSION CRITERIA:
Participants will not be eligible if they:
1. Have a condition which prevents adequate images from being obtained (e.g. unstable fixation or media opacity),
2. Have visual correction outside of the range +4 diopters (D) to -8 D,
3. Have a history of adverse reaction to mydriatic drops,
4. Have a predisposition to (i.e., narrow iridocorneal angle) or any history of acute angle closure glaucoma (AACG), or
5. Are working under the direct supervision of Drs. Hammer, Chew and Liu, or any of the NIH/NEI AIs.
All participants will be initially screened for the eligibility criteria using existing medical records (for existing participants) or during an initial eye exam (for new participants) conducted at the NEI Eye Clinic, NIH Clinical Center (CC) after initial consent is given.
Citations:
Not Provided
Contacts: