This study is currently recruiting participants.
Number
00-N-0082
Sponsoring Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 18 Years Max Age: 120 Years
Referral Letter Required
No
Population Exclusion(s)
Children
Keywords
Brain Morphology; Cerebral Blood Volume; Functional Imaging; Development; MEG; Natural History
Recruitment Keyword(s)
None
Condition(s)
Healthy Volunteer; Magnetic Resonance Imaging; Healthy; fMRI; Brain Mapping; Adult
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Neurological Disorders and Stroke
Normal healthy volunteers over 18 years old may be eligible for this study. Candidates will be screened with a medical history and questionnaire, and a neurological examination. Study participants will have a yearly MRI scan. For this procedure, the subject lies on a stretcher that is moved into a donut-shaped machine with a strong magnetic field. A lightweight circular or rectangular coil a device that improves the quality of the images may be placed on the head. The scan time varies from 20 minutes to 3 hours; most scans last between 45 and 90 minutes. During the scan, the subject may perform simple tasks, such as listening to tapes, tapping a finger, moving a hand, watching a screen, or smelling a fragrance. More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons.
Information from this study will be used to develop better imaging methods that will, in turn, permit a greater understanding of normal and abnormal brain behaviors.
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INCLUSION CRITERIA: -18 years of age and older - in good general health - able to understand the procedures and requirements and give informed consent EXCLUSION CRITERIA: All Subjects will undergo a neurological physical and answer the Healthy volunteer form, and the most-recent version of the NMR safety screening A subject will be excluded if he/she: 1. has any metal implant or objects of unknown identity or composition, or if it s known to be non-compatible with MRI, such as pacemakers, medication pumps, aneurysm clips, metallic prosthesis (such as heart valves or cochlear implants), certain orthopedic implants (pins and rods), shrapnel, or small metal fragments in the eye; 2. has claustrophobia; 3. cannot lie comfortably for up to 120 minutes; 4. underwent brain surgery or suffered a head trauma 5. has migraines that require medication; 6. has a psychiatric disorder (defined by the DSM-5); 7. has a neurological lesion or history of neurological disorders; 8. has known hearing problems; 9. is pregnant; 10. has permanent eye liner; 11. has medical problems such as, diabetes mellitus, hypertension, pulmonary or airway disease, heart failure, coronary artery disease, or history of sleep apnea. 12. has a diagnosable substance dependence 13. a member of the NINDS Laboratory of Functional and Molecular Imaging. The contraindications to MRI at the various field strengths are almost identical, except the 7 T also excludes subjects with a ferromagnetic dental crown or a bridge.
-18 years of age and older
- in good general health
- able to understand the procedures and requirements and give informed consent
EXCLUSION CRITERIA:
All Subjects will undergo a neurological physical and answer the Healthy volunteer form, and the most-recent version of the NMR safety screening
A subject will be excluded if he/she:
1. has any metal implant or objects of unknown identity or composition, or if it s known to be non-compatible with MRI, such as pacemakers, medication pumps, aneurysm clips, metallic prosthesis (such as heart valves or cochlear implants), certain orthopedic implants (pins and rods), shrapnel, or small metal fragments in the eye;
2. has claustrophobia;
3. cannot lie comfortably for up to 120 minutes;
4. underwent brain surgery or suffered a head trauma
5. has migraines that require medication;
6. has a psychiatric disorder (defined by the DSM-5);
7. has a neurological lesion or history of neurological disorders;
8. has known hearing problems;
9. is pregnant;
10. has permanent eye liner;
11. has medical problems such as, diabetes mellitus, hypertension, pulmonary or airway disease, heart failure, coronary artery disease, or history of sleep apnea.
12. has a diagnosable substance dependence
13. a member of the NINDS Laboratory of Functional and Molecular Imaging.
The contraindications to MRI at the various field strengths are almost identical, except the 7 T also excludes subjects with a ferromagnetic dental crown or a bridge.
Principal Investigator
Referral Contact
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