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Protocol Details

Characterization of Brain Morphology and Activity Using Functional and Anatomical MRI Contrast

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts




Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 120 Years

Referral Letter Required


Population Exclusion(s)



Brain Morphology;
Cerebral Blood Volume;
Functional Imaging;
Natural History

Recruitment Keyword(s)



Healthy Volunteer;
Magnetic Resonance Imaging;
Brain Mapping;

Investigational Drug(s)


Investigational Device(s)




Supporting Site

National Institute of Neurological Disorders and Stroke

The purpose of this investigation is to develop improved magnetic resonance imaging (MRI) techniques and hardware for studying brain function. MRI is a diagnostic tool that provides information about brain chemistry and physiology. This study will evaluate new MRI methods for monitoring blood flow to regions of the brain in response to simple tasks. The MRI machine used in this study is more powerful than those in most hospitals, permitting a higher visual resolution.

Normal healthy volunteers over 18 years old may be eligible for this study. Candidates will be screened with a medical history and questionnaire, and a neurological examination. Study participants will have a yearly MRI scan. For this procedure, the subject lies on a stretcher that is moved into a donut-shaped machine with a strong magnetic field. A lightweight circular or rectangular coil a device that improves the quality of the images may be placed on the head. The scan time varies from 20 minutes to 3 hours; most scans last between 45 and 90 minutes. During the scan, the subject may perform simple tasks, such as listening to tapes, tapping a finger, moving a hand, watching a screen, or smelling a fragrance. More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons.

Information from this study will be used to develop better imaging methods that will, in turn, permit a greater understanding of normal and abnormal brain behaviors.

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-18 years of age and older

- in good general health

- able to understand the procedures and requirements and give informed consent


All Subjects will undergo a neurological physical and answer the Healthy volunteer form, and the most-recent version of the NMR safety screening

A subject will be excluded if he/she:

1. has any metal implant or objects of unknown identity or composition, or if it s known to be non-compatible with MRI, such as pacemakers, medication pumps, aneurysm clips, metallic prosthesis (such as heart valves or cochlear implants), certain orthopedic implants (pins and rods), shrapnel, or small metal fragments in the eye;

2. has claustrophobia;

3. cannot lie comfortably for up to 120 minutes;

4. underwent brain surgery or suffered a head trauma

5. has migraines that require medication;

6. has a psychiatric disorder (defined by the DSM-5);

7. has a neurological lesion or history of neurological disorders;

8. has known hearing problems;

9. is pregnant;

10. has permanent eye liner;

11. has medical problems such as, diabetes mellitus, hypertension, pulmonary or airway disease, heart failure, coronary artery disease, or history of sleep apnea.

12. has a diagnosable substance dependence

13. a member of the NINDS Laboratory of Functional and Molecular Imaging.

The contraindications to MRI at the various field strengths are almost identical, except the 7 T also excludes subjects with a ferromagnetic dental crown or a bridge.

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Brain magnetic resonance imaging with contrast dependent on blood oxygenation

Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging

Perfusion imaging

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Principal Investigator

Referral Contact

For more information:

Alan P. Koretsky, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
Building 36
Room 5B05
36 Convent Drive
Bethesda, Maryland 20892
(301) 402-9659

Jeffrey H. Duyn, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
Building 10
Room B1D724
10 Center Drive
Bethesda, Maryland 20892
(301) 594-7305

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1

Clinical Trials Number:


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