This study is NOT currently recruiting participants.
Number
00-HG-0058
Sponsoring Institute
National Human Genome Research Institute (NHGRI)
Recruitment Detail
Type: Completed Study; data analyses ongoing Gender: Male & Female Min Age: 7 Years Max Age: N/A
Referral Letter Required
No
Population Exclusion(s)
Non-English Speaking
Keywords
Linkage; Gene Identification; Hyperactivity; Natural History
Recruitment Keyword(s)
Attention Deficit Hyperactivity Disorder; ADHD; Hyperactivity
Condition(s)
ADHD
Investigational Drug(s)
None
Investigational Device(s)
Intervention(s)
Supporting Site
National Human Genome Research Institute
Potentially eligible families will be asked to give written consent to participate and will be asked to complete questionnaires for each member in the family. In addition, an interview will be administered to the parent of minors enrolled in the study to determine their eligibility for being in the study. This screening tool is computerized and will take approximately 45 minutes to administer per child.
Once screenings are completed, a blood collection kit will be sent to the family to take to their local medical care provider, have blood samples drawn and sent to NIH. There is no cost to the family to participate. We would like to enroll entire families, with both parents and all children.
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INCLUSION CRITERIA: This study will enroll families with the following characteristics: 1. Families with children, seven through 17 years of age, diagnosed with ADHD (defined as the proband for the study). 2. The probands siblings, either affected with ADHD (concordant) or unaffected (discordant), seven years of age and above, including adult siblings. 3. The parents, both mothers and fathers, of enrolled probands. 4. The study will enroll both male and female probands of any ethnic background and race. The prevalence of ADHD is higher in males than in females, so we would expect to have a higher number of male probands than female probands. Both male and female siblings and male and female parents of probands will be enrolled. 5. Adults who are or may be unable to provide informed consent will be excluded. 6. Probands with one parent affected with ADHD or with neither parent affected with ADHD are eligible. Probands from bilineal families, families with both parents affected with ADHD, will be excluded for statistical reasons. Additional inclusion criteria for the study include: 1. Ability to read and understand spoken English, since the questionnaires, scales, and interviews that we have license to use in this study are in English. EXCLUSION CRITERIA: Some conditions can confound the diagnosis of ADHD. Probands with the following conditions will be excluded from enrollment or will be withdrawn from the study if the condition is discovered subsequent to enrollment: - Prematurity - Neurological conditions - Cardiac surgery - Prenatal drug exposure - Hydrocephaly - Mental Retardation (IQ<80) - Known genetic syndromes - Known CNS disorders - Known lead toxicity - Tourette Disorder - Obsessive-Compulsive Disorder - Major Depression on both proband and affected sibling - Pervasive Developmental Disorder - Age under 7 years old - Autism - Other Psychoses - Post Traumatic Stress Disorder - Language Disorder (if known) - Severe Sensory Impairment (visual and hearing) Probands with the following conditions may be included, but the conditions will be noted during statistical analysis: -Oppositional Defiant Disorder -Conduct Disorder -Tic Disorder -Obsessive/Compulsive Symptoms -Anxiety/Phobias -Learning Disabilities
This study will enroll families with the following characteristics:
1. Families with children, seven through 17 years of age, diagnosed with ADHD (defined as the proband for the study).
2. The probands siblings, either affected with ADHD (concordant) or unaffected (discordant), seven years of age and above, including adult siblings.
3. The parents, both mothers and fathers, of enrolled probands.
4. The study will enroll both male and female probands of any ethnic background and race. The prevalence of ADHD is higher in males than in females, so we would expect to have a higher number of male probands than female probands. Both male and female siblings and male and female parents of probands will be enrolled.
5. Adults who are or may be unable to provide informed consent will be excluded.
6. Probands with one parent affected with ADHD or with neither parent affected with ADHD are eligible. Probands from bilineal families, families with both parents affected with ADHD, will be excluded for statistical reasons.
Additional inclusion criteria for the study include:
1. Ability to read and understand spoken English, since the questionnaires, scales, and interviews that we have license to use in this study are in English.
EXCLUSION CRITERIA:
Some conditions can confound the diagnosis of ADHD. Probands with the following conditions will be excluded from enrollment or will be withdrawn from the study if the condition is discovered subsequent to enrollment:
- Prematurity
- Neurological conditions
- Cardiac surgery
- Prenatal drug exposure
- Hydrocephaly
- Mental Retardation (IQ<80)
- Known genetic syndromes
- Known CNS disorders
- Known lead toxicity
- Tourette Disorder
- Obsessive-Compulsive Disorder
- Major Depression on both proband and affected sibling
- Pervasive Developmental Disorder
- Age under 7 years old
- Autism
- Other Psychoses
- Post Traumatic Stress Disorder
- Language Disorder (if known)
- Severe Sensory Impairment (visual and hearing)
Probands with the following conditions may be included, but the conditions will be noted during statistical analysis:
-Oppositional Defiant Disorder
-Conduct Disorder
-Tic Disorder
-Obsessive/Compulsive Symptoms
-Anxiety/Phobias
-Learning Disabilities
Principal Investigator
Referral Contact
For more information: