NIH Clinical Center Search the Studies: Study Number, Study Title

Protocol Details

Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)

This study is NOT currently recruiting participants.

Summary | Eligibility | Citations | Contacts




Sponsoring Institute

National Human Genome Research Institute (NHGRI)

Recruitment Detail

Type: Completed Study; data analyses ongoing
Gender: Male & Female
Min Age: 7 Years
Max Age: 110 Years

Referral Letter Required


Population Exclusion(s)

Non-English Speaking


Gene Identification;
Natural History

Recruitment Keyword(s)

Attention Deficit Hyperactivity Disorder;



Investigational Drug(s)


Investigational Device(s)




Supporting Site

National Human Genome Research Institute

Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in childhood, affecting 3-5% of children between the ages of 7 and 17. Family studies suggest that there is a genetic component to ADHD. Scientists believe that it is a complex disorder in which two or more genes may be involved.

Potentially eligible families will be asked to give written consent to participate and will be asked to complete questionnaires for each member in the family. In addition, an interview will be administered to the parent of minors enrolled in the study to determine their eligibility for being in the study. This screening tool is computerized and will take approximately 45 minutes to administer per child.

Once screenings are completed, a blood collection kit will be sent to the family to take to their local medical care provider, have blood samples drawn and sent to NIH. There is no cost to the family to participate. We would like to enroll entire families, with both parents and all children.

--Back to Top--



This study will enroll families with the following characteristics:

1. Families with children, seven through 17 years of age, diagnosed with ADHD (defined as the proband for the study).

2. The probands siblings, either affected with ADHD (concordant) or unaffected (discordant), seven years of age and above, including adult siblings.

3. The parents, both mothers and fathers, of enrolled probands.

4. The study will enroll both male and female probands of any ethnic background and race. The prevalence of ADHD is higher in males than in females, so we would expect to have a higher number of male probands than female probands. Both male and female siblings and male and female parents of probands will be enrolled.

5. Adults who are or may be unable to provide informed consent will be excluded.

6. Probands with one parent affected with ADHD or with neither parent affected with ADHD are eligible. Probands from bilineal families, families with both parents affected with ADHD, will be excluded for statistical reasons.

Additional inclusion criteria for the study include:

1. Ability to read and understand spoken English, since the questionnaires, scales, and interviews that we have license to use in this study are in English.


Some conditions can confound the diagnosis of ADHD. Probands with the following conditions will be excluded from enrollment or will be withdrawn from the study if the condition is discovered subsequent to enrollment:

- Prematurity

- Neurological conditions

- Cardiac surgery

- Prenatal drug exposure

- Hydrocephaly

- Mental Retardation (IQ<80)

- Known genetic syndromes

- Known CNS disorders

- Known lead toxicity

- Tourette Disorder

- Obsessive-Compulsive Disorder

- Major Depression on both proband and affected sibling

- Pervasive Developmental Disorder

- Age under 7 years old

- Autism

- Other Psychoses

- Post Traumatic Stress Disorder

- Language Disorder (if known)

- Severe Sensory Impairment (visual and hearing)

Probands with the following conditions may be included, but the conditions will be noted during statistical analysis:

-Oppositional Defiant Disorder

-Conduct Disorder

-Tic Disorder

-Obsessive/Compulsive Symptoms


-Learning Disabilities

--Back to Top--


DSM-III disorders in preadolescent children Prevalence in a large sample from the general population

A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders

Genetic heterogeneity in attention-deficit hyperactivity disorder (ADHD): gender psychiatric comorbidity and maternal ADHD

--Back to Top--


Principal Investigator

Referral Contact

For more information:

Maria T. Acosta, M.D.
National Human Genome Research Institute (NHGRI)
NIHBC 10 - CRC BG RM 3-2551
(301) 451-2451

Maria T. Acosta, M.D.
National Human Genome Research Institute (NHGRI)
NIHBC 10 - CRC BG RM 3-2551
(301) 451-2451

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1

Clinical Trials Number:


--Back to Top--