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Protocol Details

Diagnosis, Pathophysiology, and Molecular Biology of Pheochromocytoma and Paraganglioma

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

00-CH-0093

Sponsoring Institute

National Institute of Child Health and Human Development (NICHD)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 3 Years
Max Age: 120 Years

Referral Letter Required

No

Population Exclusion(s)

Pregnant Women

Keywords

Genetics;
Metanephrines;
PET;
Catecholamines

Recruitment Keyword(s)

None

Condition(s)

Pheochromocytoma;
Endocrine Disease;
Endocrine Diseases

Investigational Drug(s)

[18F]-L-3,4-dihydroxyphenylalanine
[18F]-6F-Dopamine

Investigational Device(s)

None

Intervention(s)

Drug: ([18F]-DOPA)
Drug: ([18F]-6F-DA)

Supporting Site

National Institute of Child Health and Human Development

The goal of this study is to develop better methods of diagnosis, localization, and treatment for pheochromocytomas. These tumors, which usually arise from the adrenal glands, are often difficult to detect with current methods. Pheochromocytomas release chemicals called catecholamines, causing high blood pressure. Undetected, the tumors can lead to severe medical consequences, including stroke, heart attack and sudden death, in situations that would normally pose little or no risk, such as surgery, general anesthesia or childbirth.

Patients with pheochromocytoma may be eligible for this study. Candidates will be screened with a medical history and physical examination, electrocardiogram, and blood and urine tests. Study participants will undergo blood, urine, and imaging tests, described below, to detect pheochromocytoma. If a tumor is found, the patient will be offered surgery. If surgery is not feasible (for example, if there are multiple tumors that cannot be removed), evaluations will continue in follow-up visits. If the tumor cannot be found, the patient will be offered medical treatment and efforts to detect the tumor will continue. Main diagnostic and research tests may include the following:

1. Blood tests - mainly measurements of plasma or urine catecholamines and metanephrines as well as methoxytyramine. If necessary the clonidine suppression test can be carried out.

2. Standard imaging tests - Non-investigational imaging tests include computed tomography (CT), magnetic resonance imaging (MRI), sonography, and 123I-MIBG scintigraphy and FDG (positron emission tomography) PET/CT. These scans may be done before and/or after surgical removal of pheochromocytoma.

3. Research PET scanning is done using an injection of radioactive compounds. Patients may undergo 18F-FDOPA, 18F-DA, as well as 68Ga-DOTATATE PET/CT . Each scan takes up to about 2 hours.

4. Genetic testing - A small blood sample is collected for DNA analysis and other analyses.

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Eligibility

INCLUSION CRITERIA:

Patients are eligible for inclusioni this study if they are adults or children of age 3 years old and up with known, sporadic or familial PHEO/PGL, on the basis of one or more of the following:

(a) High levels of blood or urinary catecholamines, metanephrines, methoxytyramine or chromogranin A.

(b) Highly suspected presence of PHEO/PGL based on imaging studies, even with normal biochemistry.

(c) Personal or family history of PHEO/PGL or genetic pathogenic variants known to predispose individuals to develop PHEO/PGL.

Signed informed consent is required. The informed consent may be signed by the patient, parent/guardian in pediatric patients or legally authorized representative (LAR) in adults who lackdecision making capacity to consent to research participation.

Patients must have an outside general practitioner or endocrinologist. Patients with metastatic disease must also have an outside oncologist.

Family Member of Patients Arm (Linkage Analysis)

Participants are eligible for inclusion in this study arm if they are:

-Adult family members of patients enrolled in this study:

-The index family member in this study has a suspected hereditary PHEO/PGL based on previous genetic testing and other suspicious hereditory patterns such as family history of multiple individuals with PHEO/PGL: early age of disease onset: multiplicity of primary tumors: recurrence, etc. and

-Signed informed consent form is required

EXCLUSION CRITERIA:

Potential patients will be excluded on the basis of one or more of the following:

(a) Pregnant or breastfeeding women

(b) Severe cardiac dysfunction

(c) Currently on dialysis

A pregnancy test is performed in women of childbearing age (up to age 55) as a screening after consenting. If a patient is found to have a positive pregnancy test, her participation in this protocol will be terminated. The patient can enroll or re-enroll in the protocol when she is no longer pregnant or breastfeeding.

In-person participating patients who are not willing to return to the NIH (e.g., after surgery or an initial evaluation) for more than 2 years may be removed from the protocol.

SPECIFIC INCLUSION/EXCLUSION CRITERIA FOR IMAGING STUDIES WITHIN OUR PROTOCOL:

In adult patients (Excludes Linkage Analysis Arm):

Imaging studies are not done in patients that have the following exclusion criteria:

-Inability to lie still for the entire imaging time (e.g., cough, severe arthritis, etc.).

-Inability to complete the needed investigational and standard-of-care imaging examinations due to other reasons (e.g., severe claustrophobia, radiation phobia, etc.)

- Any additional medical conditions, serious illness, or other extenuating circumstance that, in the opinion of the Principal Investigator, may significantly interfere with study compliance.

In pediatric patients:

Inclusion criteria for research PET imaging in children:

-Children over 10 years old with very high suspicion of sporadic or familial PHEO/PGL based on at least one of the following:

--The presence of new onset of symptoms typical of PHEO/PL such as hypertension or hypertensive episodes, sweating, headaches, pallor, palpitations, drug resistant hypertension, etc.

--Family history of PHEO/PGL or genetic pathogenic variants known to predispose individuals to develop these tumors.

--The presence of a tumor on conventional imaging including ultrasound, CT and/or MRI or [123I]-MIBG or PET imaging not limited to [18F]-FDG.

-Children must give informed assent and be willing to return to the NIH for follow-up.

Exclusion criteria for research PET imaging in children:

-Children of less than 10 years of age.

-Children with impaired mental capacity that precludes informed assent.

-Inability to lie still for the entire imaging time (e.g., cough, turbulent children, severe claustrophobia, etc.).


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Citations:

Not Provided

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Contacts:

Principal Investigator

Referral Contact

For more information:

Karel Pacak, M.D.
National Institute of Child Health and Human Development (NICHD)
NIHBC 10 - CRC BG RM 1-3140
10 CENTER DR
BETHESDA MD 20892
(301) 402-4594
karel@mail.nih.gov

Alberta Derkyi, C.R.N.P.
National Institute of Child Health and Human Development (NICHD)
NIHBC 10 - CLINICAL CENTER BG RM 8N248C
10 CENTER DR
BETHESDA MD 20892
(301) 827-3355
alberta.derkyi@nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1
ccopr@nih.gov

Clinical Trials Number:

NCT00004847

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