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Protocol Details

Genetics of COVID-19 Susceptibility and Manifestations

This study is NOT currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

20-HG-0090

Sponsoring Institute

National Human Genome Research Institute (NHGRI)

Recruitment Detail

Type: Clinical hold/Recruitment or enrollment suspended
Gender: Male & Female
Min Age: 1 mo
Max Age: N/A

Referral Letter Required

Yes

Population Exclusion(s)

None

Special Instructions

Currently Not Provided

Keywords

SARS-CoV-2;
Whole Exome Sequencing;
Coronavirus 2019

Recruitment Keyword(s)

None

Condition(s)

COVID-19;
Coronavirus 2019

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Human Genome Research Institute

Background:

Coronavirus 2019 (COVID-19, or SARS-CoV-2) is a serious public health problem, and genetics may play a role in how serious the illness becomes in certain people. Genes are the instructions that our body uses to grow and develop. Variations in our genes can cause medical conditions and may be the reason why some people get sicker than others.

Objective:

This study aims to learn more about the genetic contributions to the severity of COVID-19. We hope to use this information to develop therapies that reduce the severity of COVID-19 symptoms in some people.

Eligibility:

Anyone located in the United States who has tested positive for SARS-CoV-2 infection may be eligible to join (including NIH staff).

Design:

Participants will complete a questionnaire about their health history and COVID-19 symptoms.

Participants will give a blood or saliva sample. It will be about 2 tablespoons of blood, or we will send a saliva collection kit. Researchers will use this blood or saliva sample to study the participant s DNA.

The data about participants genes will be stored in a large database. The database will be shared with other qualified researchers who are trying to learn about COVID-19. Participants names and other personal details will not be shared. Instead, the data will be labeled with a code.

Participants may be contacted by study team members for up to a year after they join the study.

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Eligibility

INCLUSION CRITERIA

- Cohort 1 (Existing NIH Clinical Center Patient/Participants invited to participate by their NIH study team)

-Cohort 2 (Individuals recruited through NIH Occupational Medicine Services (OMS) patients referred by NIH investigators or other providers; individuals who self-refer)

-Located in the United States

-Positive test for SARS-CoV-2 virus infection

-Age greater than or equal to 3 years old

*only for participants providing a blood sample

EXCLUSION CRITERIA:

-Individuals for whom we cannot consent for participation in a language offered by our existing interpretation service.

-Weight less than 10 kg*


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Citations:

Not Provided

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Contacts:

Principal Investigator

Referral Contact

For more information:

Leslie G. Biesecker, M.D.
National Human Genome Research Institute (NHGRI)



Julie Sapp
National Human Genome Research Institute (NHGRI)
National Institutes of Health
Building 10
Room 3C710
10 Center Drive
Bethesda, Maryland 20892
Not Listed
covidcode@nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010
PRPL@cc.nih.gov

Clinical Trials Number:

NCT04371432

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