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Protocol Details

Teaching Protocol for the Evaluation of Plasma Lipoproteins

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

79-H-0100

Sponsoring Institute

National Heart, Lung and Blood Institute (NHLBI)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: N/A
Max Age: N/A

Referral Letter Required

Yes

Population Exclusion(s)

None

Special Instructions

Currently Not Provided

Keywords

Dyslipoproteinemia;
Hypercholesterolemia;
Hypertriglyceridemia;
hypoalphalipoproteinemia;
Atherosclerosis

Recruitment Keyword(s)

Type III Hyperlipoproteinemia;
Plasma Lipoproteins

Condition(s)

Hyperlipidemia;
Hyperlipoproteinemia;
Hypolipoproteinemia

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Heart, Lung, and Blood Institute

Lipoproteins are particles that carry fats such as cholesterol and triglycerides through the blood stream. These particles are involved in causing blood vessel disease that can lead to conditions like hardening of the arteries (atherosclerosis) or heart attacks (myocardial infarctions).

This study is designed to look closely at the factors affecting lipoproteins. Researchers plan to study patients and normal volunteers by measuring lipoprotein levels in the blood. Patients and volunteers will be placed on a balanced diet during the study. In addition, researchers plan to measure levels of various hormone and enzymes in the blood. Patients and volunteers participating in the study may be asked to undergo more specific tests in order to collect more information about lipoprotein metabolism.

This study may not provide direct benefits to patients and volunteers participating in it. However, information gathered from this study may help researchers develop better skills and techniques to diagnose and treat patients with diseases of lipoprotein metabolism.

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Eligibility

INCLUSION CRITERIA:

Plasma cholesterol levels greater than 200 mg/dl or less than 120 mg/dl - includes patients with diagnoses such as familial hypercholesterolemia, familial combined hyperlipidemia, sitosterolemia, cholesteryl ester storage disease, Erdheim chester disease, lipoprotein lipase, hepatic lipase or apo-CII deficiency, and dysbetalipoproteinemia.

Plasma LDL-C levels greater than 130 mg/dl or less than 70 mg/dl - includes patients with diagnoses such as familial hypercholesterolemia, familial combined hyperlipidemia, lipoprotein lipase, hepatic lipase, or apo-CII deficiency, sitosterolemia, dysbetalipoproteinemia, abetalipoproteinemia and hypobetalipoproteinemia.

Plasma HDL-C levels greater than 70 mg/dl or less than 25 mg/dl - includes patients with deficiency of cholesteryl ester transfer protein, lecithin cholesterol acyltransferase, phospholipid transfer protein, lipoprotein lipase, hepatic lipase, or apo-CII, and Tangier disease.

Plasma triglyceride levels greater than 150 mg/dl - includes patients with deficiency of lipoprotein lipase, hepatic lipase or apoC-II, dysbetalipoproteinemia, Type IV and Type V hyperlipidemia.

EXCLUSION CRITERIA:

Inability to provide informed consent.


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Citations:

In vitro expression of structural defects in the lecithin-cholesterol acyltransferase gene

Dominant expression of type III hyperlipoproteinemia: pathophysiological insights derived from the structural and kinetic characteristics of apoE-1

Homozygosity for two point mutations in the lipoprotein lipase (LPL) gene in a patient with familial LPL deficiency

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Contacts:

Principal Investigator

Referral Contact

For more information:

Robert D. Shamburek, M.D.
National Heart, Lung and Blood Institute (NHLBI)
BG 10 RM 8N202
10 CENTER DR
BETHESDA MD 20814
(301) 496-3460
bobs@mail.nih.gov

Robert D. Shamburek, M.D.
National Heart, Lung and Blood Institute (NHLBI)
BG 10 RM 8N202
10 CENTER DR
BETHESDA MD 20814
(301) 496-3460
bobs@mail.nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010
PRPL@cc.nih.gov

Clinical Trials Number:

NCT00001168

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