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Protocol Details

Characterization Imaging Instruments in Alcoholics and Non-Alcoholics

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts




Sponsoring Institute

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18
Max Age: 65

Referral Letter Required


Population Exclusion(s)


Special Instructions

Currently Not Provided



Recruitment Keyword(s)



Alcohol Dependence;
Alcohol Drinking;
Alcohol-Related Disorders;
Brain Mapping

Investigational Drug(s)


Investigational Device(s)




Supporting Site

National Institute on Alcohol Abuse and Alcoholism


- People with alcoholism have differences in their brains compared with healthy people. People who are dependent on alcohol also perform differently on behavioral tasks. Researchers want to find out more about these differences. They also want to see if these differences are related to DNA.


- To see if differences in brain structure relate to personality and behavior differences in people with and without alcohol dependence.


- Adults age 18 and older.


- Participants will visit the NIH Clinical Center once during the study.

- Participants will be screened with a medical history, EKG, and physical exam. They will give blood and urine samples and undergo a psychiatric interview.

- Participants will be asked about their alcohol drinking, to see if they have an alcohol use disorder.

- Participants will play three computerized games. Some will play these games inside a magnetic resonance imaging (MRI) scanner.

-MRI: strong magnetic field and radio waves take pictures of the brain. Participants lie on a table that slides in and out of a cylinder. They will be in the scanner for about 90 minutes. They may lie still for up to 20 minutes at a time. The scanner makes loud knocking noises. They will get earplugs.

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All adult participants must have:

-Enrolled in screening protocol 14-AA-0181, Unit and Clinic Evaluation, Screening, Assessment, and Management or have been determined eligible for another NIAAA study.

-Task performance (behavioral and fMRI) only: Are cleared based on neuromotor examination as determined by the screening protocol 14-AA-0181.


-Exclusion criteria for MR scan

--Presence of ferromagnetic objects in the body that are contraindicated for MRI of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments) or fear of enclosed spaces. Eligibility will be determined by a "MRI Safety Screening Questionnaire" and verified, if necessary, by a physician.

--Cannot lie comfortably flat on back for up to 2 hours in the MRI scanner.

--Uncomfortable in enclosed spaces (has claustrophobia) such that they would feel discomfort in the scanner

--Women: Are pregnant

--Are left-handed.

-Inpatient participants with alcohol dependence who have symptoms of alcohol withdrawal as indicated by the most recent measurement within the past 30 days, as measured by the Clinical Institute Withdrawal Assessment (CIWA-Ar) score >= 8 (with sub-score more than zero for orientation and more than 2 for all others).

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Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, Stevens MC, O'Malley S, Book GA, Reynolds B, Pearlson GD. Individuals family history positive for alcoholism show functional magnetic resonance imaging differences in reward sensitivity that are related to impulsivity factors. Biol Psychiatry. 2011 Apr 1;69(7):675-83. doi10.1016/j.biopsych.2010.09.049. Epub 2010 Dec 3.

Baker KG, Harding AJ, Halliday GM, Kril JJ, Harper CG. Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke's encephalopathy. Neuroscience. 1999;91(2):429-38.

Bjork JM, Hommer DW, Grant SJ, Danube C. Impulsivity in abstinent alcohol-dependent patients: relation to control subjects and type 1-/type 2-like traits. Alcohol. 2004 Oct-Nov;34(2-3):133-50.

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Principal Investigator

Referral Contact

For more information:

Reza Momenan, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institutes of Health
Building 10
Room 3C112
10 Center Drive
Bethesda, Maryland 20892
(301) 451-6972

Reza Momenan, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institutes of Health
Building 10
Room 3C112
10 Center Drive
Bethesda, Maryland 20892
(301) 451-6972

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010

Clinical Trials Number:


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