National Institute of Mental Health (NIMH)s

National Institute of Mental Health (NIMH)

62 Protocols (54 Active Accrual of new subjects, 8 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 19-M-0079:
Evaluation of Novel PET Radioligands as Inflammatory Biomarkers in Rheumatoid Arthritis and Myositis

* 19-M-0073:
Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)

* 19-M-0064:
Evaluation of a Novel PET Radioligand for Phosphodiesterase-4D (PDE4D)

* 19-M-0054:
Mapping the Phenotype in Adults with Phelan-McDermid Syndrome

* 18-M-0144:
The effects of an estrogen receptor (ER) beta agonist (Lilly Compound LY500307) on estradiol-withdrawal-induced mood symptoms in women with past perimenopausal depression.

* 18-M-0037:
Characterization and Treatment of Adolescent Depression

* 18-M-0036:
Clinical, Laboratory, and Biomedical Characterization of Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)

* 18-M-0015:
Development of Non-Invasive Brain Stimulation Techniques

* 17-M-0181:
Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies

* 17-M-0179:
Evaluation of a Novel PET Radioligand to Image Cyclooxygenase-1 (COX-1)

* 17-M-0147:
Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

* 17-M-0060:
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

* 17-M-0046:
Effects of SRX246, a Vasopressin Receptor (V1a) Antagonist, on an Experimental Model of Fear and Anxiety in Humans

* 17-M-0042:
The Effect of Transcranial Magnetic Stimulation to the Frontoparietal Attention Network on Anxiety Potentiated Startle

* 15-M-0188:
The Neurobiology of Suicide

* 15-M-0182:
Psychological Treatments for Youth with Severe Irritability.

* 15-M-0151:
An Investigation of the Antidepressant Effects of the Glycine Receptor Antagonist AV 101 (4-chlorokynurenine) in Major Depressive Disorder

* 15-M-0139:
Mapping the Genotype, Phenotype, and Natural History of Phelan McDermid Syndrome

* 15-M-0109:
Checking out Checking In: The Development and Validation of an Electronic Screening Tool for Pediatric Psychosocial Distress

* 15-M-0066:
Influence on Plasticity of Brain Temperature

* 14-M-0109:
Ask Suicide-Screening Questions to Everyone in Medical Settings (asQ'em): Development of a Suicide Risk Screening Instrument for Adult Medical Inpatients

* 13-M-0190:
Imaging and Genetic Investigation of Learning and Decision Making

* 13-M-0028:
Diagnosis and Treatment of Childhood-onset Behavioral Disorders, Neuropsychiatric Disorders and Neurodevelopmental Disorders

* 12-M-0128:
TMS Investigations of the Human Visual System

* 11-M-0251:
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

* 11-M-0045:
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

* 10-M-0112:
Defining the Brain Phenotype of Children with Williams Syndrome

* 10-M-0047:
Top-Down Attentional Control of Visual-Processing

* 10-M-0027:
Cognitive Neuroscience of Autism Spectrum Disorders

* 09-M-0176:
Functional Relevance of Dopamine Receptors in Healthy Controls and Patients with Schizophrenia: Characterization through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

* 07-M-0021:
Development of Functional and Structural Magnetic Resonance Imaging Techniques for the Study of Mood and Anxiety Disorders

* 06-M-0214:
PET Measurement of Regional Rates of Cerebral Protein Synthesis in Subjects with Fragile X Syndrome

* 06-M-0065:
The Neurodevelopmental and Behavioral Phenotyping Screening Protocol

* 05-M-0144:
MRS (Magnetic Resonance Spectroscopy) Measurement of Glutamate and GABA Metabolism in Brain

* 03-M-0211:
Family Study of Affective and Anxiety Spectrum Disorders

* 03-M-0186:
The Psychobiology of Temperament: An fMRI Study

* 03-M-0093:
Predictability and Aversive Expectancies in Anxiety and Depressive Disorders

* 02-M-0321:
fMRI Investigation of Explicit Cue and Contextual Fear

* 02-M-0021:
Characterization and Pathophysiology of Severe Mood and Behavioral Dysregulation in Children and Youth

* 01-M-0254:
The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers

* 01-M-0232:
Positron Emission Tomography (PET) Scanning in Dopamine Disorders: Parkinson's Disease and Schizophrenia

* 01-M-0192:
Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes

* 01-M-0185:
Effects of Arousal and Stress on Classical Conditioning

* 00-M-0085:
Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 3.0 Tesla MRI and Magnetoencephalography

* 95-M-0150:
A Neurobiological Investigation of Patients with Schizophrenia Spectrum Disorders and Their Siblings

* 95-M-0097:
An Endocrine Model for Postpartum Mood Disorders

* 93-M-0170:
Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

* 92-M-0174:
The Central Nervous System Effects of Pharmacologically Induced Hypogonadotropic Hypogonadism with and without Estrogen and Progesterone Replacement

* 90-M-0088:
The Treatment of Menstrually-Related Mood Disorders with the Gonadotropin Releasing Hormone (GnRH) Agonist, Depot Leuprolide Acetate (Lupron)

* 89-M-0160:
Inpatient Evaluation of Neuropsychiatric Patients

* 89-M-0006:
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

* 88-M-0131:
The Evaluation of Women with Perimenopause-Related Mood and Behavioral Disorders

* 81-M-0126:
The Evaluation of Women with Menstrually Regulated Mood and Behavioral Disorders

* 80-M-0083:
Bipolar Genetics: A Collaborative Study

Active Follow-up, Protocols NOT Recruiting New Patients 

* 19-M-0095:
PET Imaging of Neuroinflammation in Neurodegenerative Diseases via a Novel TSPO Radioligand

* 16-M-0105:
Evaluation of a Novel PET Radioligand to Image OGA

* 14-M-0114:
Cognitive vs. Emotional Psycho-Pharmacological Manipulations of Fear vs. Anxiety

* 09-M-0177:
CO2 Inhalation and Risk for Panic Disorder

* 09-M-0034:
A Controlled Trial of Citalopram Added to Methylphenidate in Youth with Severe Mood Dysregulation

* 08-M-0052:
fMRI Investigation of Cortical Reorganization and Phantom Limb Pain Following Amputation

* 00-M-0198:
The Phenomenology and Neurophysiology of Affective Dysregulation in Children and Adolescents with Bipolar Disorder

* 90-M-0014:
Studies of Frontal Lobe Function During Cognitive Stimulation as Measured with Oxygen-15 Water Positron Emission Tomography in Normal Subjects and Patients with Neuropsychiatric Disorders