National Institute of Mental Health (NIMH)s

National Institute of Mental Health (NIMH)

67 Protocols (39 Active Accrual of new subjects, 28 Follow-up of previously enrolled subjects)

 002536-M:

Evaluation of [11C]ZTP-1 to Image PDE4B

 002393-M:

Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

 002277-M:

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers with Alzheimer s Disease (AD) or Mild Cognitive Impairment (MCI)

 002210-M:

PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

 002117-M:

PET Imaging of Cyclooxygenase-1 in Participants with Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)

 002073-M:

Characterizing the Brain Circuitry and Neural Activity Mediating Frustration

 001937-M:

Phase II Efficacy Study of Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety

 001874-M:

Natural History of Depression, Bipolar Disorder and Suicide Risk

 001777-M:

Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers

 001602-M:

An Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

 000978-M:

State-Dependent Interoception, Value-Based Decision Making, and Introspection

 000754-M:

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

 000744-M:

Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial

 000676-M:

[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET

 21-M-0018:

Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array

 20-M-0166:

Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations

 20-M-0159:

Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder

 20-M-0157:

PET Imaging of Cyclooxygenase in Participants with Major Depressive Disorder (MDD)

 20-M-0082:

Phase 1 Study: PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

 20-HG-0147:

An Observational Study of the Developing Brain, Impulsivity and Compulsivity

 19-M-0107:

The Mechanism of Action Underlying Ketamine's Antidepressant Effects: An Investigation of the AMPA Throughput Theory in Patients with Treatment-Resistant Major Depression

 18-M-0037:

Characterization and Treatment of Adolescent Depression

 17-M-0181:

Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies

 17-M-0060:

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

 15-M-0188:

The Neurobiology of Suicide

 15-M-0182:

Psychological Treatments for Youth with Severe Irritability

 13-M-0028:

Diagnosis of Childhood-onset Behavioral Disorders, Neuropsychiatric Disorders and Neurodevelopmental Disorders

 12-M-0128:

TMS Investigations of the Human Visual System

 11-M-0251:

A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

 11-M-0045:

Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

 10-M-0112:

Defining the Brain Phenotype of Children with 7q11.23 Copy Number Variation, Including Williams Syndrome and 7q11.23 Duplication Syndrome

 10-M-0047:

Top-Down Attentional Control of Visual-Processing

 07-M-0021:

Development of Functional and Structural Magnetic Resonance Imaging Techniques for the Study of Mood and Anxiety Disorders

 06-M-0065:

Neurodevelopmental and Behavioral Phenotyping Screening Protocol

 05-M-0144:

MRS (Magnetic Resonance Spectroscopy) Measurement of Glutamate and GABA Metabolism in Brain

 02-M-0021:

Characterization and Pathophysiology of Severe Mood and Behavioral Dysregulation in Children and Youth

 01-M-0254:

The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers

 01-M-0192:

Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders

 93-M-0170:

Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

 002713-M:

Psychotherapy for Irritability in Youth: Comparing Active Treatment to Non-Active Psychoeducation Supportive Psychotherapy

 002632-M:

Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth with Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)

 000527-M:

CNS Correlates of Extended Sleep Restriction

 000101-M:

An Investigation of the Antidepressant Effects of the mGlu2/3 Receptor Antagonist TS-161 in Treatment-Resistant Depression

 21-M-0031:

A Feasibility Study of Transcranial Electric Stimulation Therapy (TEST) for treatment resistant depression (TRD)

 20-M-0066:

Validating the Ask Suicide-Screening Questions (ASQ) for Youth with Autism Spectrum and Neurodevelopmental Disorders

 18-M-0144:

The Effects of an ER Beta Agonist (Lilly Compound LY500307) on Estradiol-withdrawal-induced Mood Symptoms in Women with Past Perimenopausal Depression

 18-M-0015:

Development of Non-Invasive Brain Stimulation Techniques

 17-M-0147:

Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

 15-M-0151:

An Investigation of the Antidepressant Effects of the Glycine Receptor Antagonist AV 101 (4-chlorokynurenine) in Major Depressive Disorder

 15-M-0139:

Mapping the Genotype, Phenotype, and Natural History of Phelan McDermid Syndrome

 15-M-0066:

Influence on Plasticity of Brain Temperature

 10-M-0027:

Cognitive Neuroscience of Autism Spectrum Disorders

 09-M-0176:

Functional Relevance of Dopamine Receptors in Healthy Controls and Patients with Schizophrenia: Characterization through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

 03-M-0211:

Family Study of Affective and Anxiety Spectrum Disorders

 03-M-0186:

The Psychobiology of Temperament: An fMRI Study

 01-M-0232:

Positron Emission Tomography (PET) Scanning in Dopamine Disorders: Parkinson's Disease and Schizophrenia

 00-M-0085:

Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 3.0 Tesla MRI and Magnetoencephalography (MEG)

 95-M-0150:

A Neurobiological Investigation of Patients with Schizophrenia Spectrum Disorders and Their Siblings

 95-M-0097:

An Endocrine Model for Postpartum Mood Disorders

 92-M-0174:

The Central Nervous System Effects of Pharmacologically Induced Hypogonadotropic Hypogonadism with and without Estrogen and Progesterone Replacement

 90-M-0088:

The Treatment of Menstrually-Related Mood Disorders with the Gonadotropin Releasing Hormone (GnRH) Agonist, Depot Leuprolide Acetate (Lupron)

 90-M-0014:

Studies of Frontal Lobe Function During Cognitive Stimulation as Measured with Oxygen-15 Water Positron Emission Tomography in Normal Subjects and Patients with Neuropsychiatric Disorders

 89-M-0160:

Inpatient Evaluation of Neuropsychiatric Patients

 89-M-0006:

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

 88-M-0131:

The Evaluation of Women with Perimenopause-Related Mood and Behavioral Disorders

 81-M-0126:

The Evaluation of Women with Menstrually Regulated Mood and Behavioral Disorders

 80-M-0083:

Bipolar Genetics: A Collaborative Study