National Institutes of Health Clinical Center (CC)s

National Institutes of Health Clinical Center (CC)

77 Protocols (47 Active Accrual of new subjects, 30 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 19-CC-0063:
Impact of Steady State Cobicistat and Darunavir/Dobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Healthy Volunteers (CLOTRx)

* 19-CC-0055:
Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes after Hepatitis C Eradication (CHROME)

* 19-CC-0035:
Characterizing Fatigue Experienced by Registered Nurses

* 19-CC-0005:
Short or Long Infusion Duration of Platelets: The SOLID Platelet Study

* 19-CC-0004:
Motivations, Expectations, and Decision-making of Sickle Cell Patients in Clinical Research

* 18-CC-0117:
PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects

* 18-CC-0112:
A Phase 1 Clinical Trial of ABI-009, an mTOR Inhibitor, for Patients with Severe Pulmonary Arterial Hypertension (PAH)

* 18-CC-0087:
Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA)

* 18-CC-0079:
Pilot RCT of Web-based Behavioral Sleep Intervention for Individuals with Alcohol Use Disorder

* 18-CC-0052:
Near-infrared Spectroscopy and Electroencephalography to Assess Cortical Activation During Motor Tasks in Infants and Toddlers with and without Cerebral Palsy

* 18-CC-0013:
A Randomized, Double-Blind, Placebo-Controlled Study of a Single Dose of Pembrolizumab in HIV-Infected People

* 17-CC-0148:
Obtaining Samples from Human Subjects to Facilitate Basic, Translational and Clinical Research

* 17-CC-0111:
Pilot Study Characterizing Aerobic Exercise in Women with Systemic Lupus Erythematosus (Exercise SLE Pilot)

* 16-CC-0168:
Focus Groups to Determine Surrogates Views Regarding Patient Preference Predictors

* 16-CC-0149:
Dopamine and Motor Learning in Cerebral Palsy

* 16-CC-0112:
Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted with Cobicistat in Healthy Volunteers

* 16-CC-0098:
Pilot Study of Ultrasound Guided Focal Thermal Ablation of Prostate Cancer

* 16-CC-0049:
A Phase II Study Using LC Bead LUMI Radio-Opaque Embolic Beads to Detect and Characterize the Vascularity of Hepatic Tumors During Treatment with Transarterial Embolization (TAE) Alone or Combined with Thermal Ablation

* 16-CC-0001:
Evaluation of MiSeq for Microbial Identification in Specimens

* 15-CC-0164:
Effect of Exercise Training on Physical, Cognitive and Behavioral Function in Patients with Traumatic Brain Injury

* 15-CC-0091:
Pulmonary Effects of Bronchial Segmental Endotoxin Instillation in Humans

* 14-CC-0158:
Imaging Techniques in CT: Technical Development

* 14-CC-0027:
The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients with Interstitial Lung Disease

* 13-CC-0210:
Evaluating an Extension Assist Knee Ankle Foot Orthosis to Improve Gait in Children with Movement Disorders

* 13-CC-0180:
Studies of the Human Microbiome in Clinical Center Patients

* 13-CC-0110:
Near-infrared Spectroscopy and Electroencephalography to Assess and Train Cortical Activation During Motor Tasks

* 13-CC-0099:
Vasti Control of Patellofemoral Kinematics in Patients with Chronic Patellofemoral Pain

* 13-CC-0079:
Fusion Guided Thermal Ablation Combined With External Beam Radiation for Hepatic Neoplasms

* 13-CC-0012:
A Natural History Study of Novel Biomarkers in Pulmonary Arterial Hypertension

* 12-CC-0211:
A Pilot Study of the Effect of Spironolactone Therapy on Exercise Capacity and Endothelial Dysfunction in Pulmonary Arterial Hypertension

* 12-CC-0139:
Estimation of Brain Biomechanics using MRI

* 12-CC-0096:
Collection of Granulocytes by Apheresis of Healthy Donors Stimulated with Filgrastim (G-CSF) and Dexamethasone

* 11-CC-0152:
The Natural History of Liver Disease in a Cohort of Participants with Hepatitis B and/or Hepatitis C with or without HIV Infection

* 11-CC-0120:
Stereophotogrammetry of the Torso in Normal Individuals and Patients with Scoliosis, Chest Wall Deformations, or Obesity

* 10-CC-0118:
Long Term Clinical Correlates of TBI: Imaging, Biomarkers, and Clinical Phenotyping Parameters

* 10-CC-0115:
Imaging Techniques in MRI

* 05-CC-0091:
Electromagnetic Tracking of Devices During Interventional Procedures

* 04-CC-0119:
Biomarkers and Protein Mass Expression Profiles in Bronchoalveolar Lavage from Patients with Lung Infiltrates

* 03-CC-0128:
Development and Evaluation of Techniques for Computer Aided Detection and Diagnosis from Radiologic Images

* 03-CC-0060:
Virtual Functional Anatomy (VFA)

* 02-CC-0266:
Acute Cardiac Allograft Cellular Rejection and Cardiac Allograft Vasculopathy: Identification of Diagnostic Biomarkers and Target Pathways for Preventive Therapy

* 01-CC-0231:
A Prospective Study of Transfusion-Transmitted Infections

* 01-CC-0045:
Studies of Phlebotomy Therapy in Hereditary Hemochromatosis

* 99-CC-0168:
Collection and Distribution of Blood Components from Healthy Donors for In Vitro Research Use

* 98-CC-0019:
Volunteer Scanning on MR

* 90-CC-0168:
A Rigid Body Database on Human Movement

* 87-CC-0091:
Magnetic Resonance Imaging at 1.5 and 3.0 Tesla

Active Follow-up, Protocols NOT Recruiting New Patients 

* 19-CC-0070:
Translational Development of Photon-Counting CT Imaging

* 19-CC-0052:
The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers (SEARCH PK)

* 17-CC-0010:
Exploring the Influence of Psychosocial Distress and Lifetime Trauma Exposure on Traumatic Stress Among Oncology Patients on Clinical Trials

* 16-CC-0162:
Longitudinal Changes in the Oral and Gut Microbiome of Individuals with Alcohol Dependence

* 16-CC-0056:
Analysis of a Tool to Assess Psycho Social Spiritual Healing: Cognitive Interviewing

* 15-CC-0193:
A Retrospective/Prospective Study to Assess Safety, Tolerability, and Efficacy of Sofosbuvir based Direct Acting Antiviral (DAA) Therapy for Hepatitis C Treatment in HIV/HCV Coinfected Subjects Pre or Post Liver Transplant

* 15-CC-0103:
Evaluation of Neurocognitive Driving Rehabilitation in Virtual Environments (NeuroDRIVE) as an Adjunctive Intervention for Traumatic Brain Injury

* 14-CC-0201:
A Randomized Controlled Trial to Determine the Effectiveness of a Stress Reduction Intervention in Caregivers of Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients

* 14-CC-0179:
Losartan to Reduce Inflammation and Fibrosis Endpoints in HIV (LIFE-HIV) Trial

* 14-CC-0143:
Sleep Disturbance and Relapse in Individuals with Alcohol Dependence: An Exploratory Mixed Methods Study

* 13-CC-0178:
Prospective Pilot Observational Study Examining Cone Beam CT and CT Thermometry During Ablations

* 13-CC-0161:
A Description of the Oral Microbiome of Patients with Severe Aplastic Anemia

* 13-CC-0003:
Imaging Techniques in fMRI and fMRI Reproducibility: An NIH/FDA Interagency Collaboration

* 11-CC-0088:
Effect of Aerobic Exercise Training on Cardiorespiratory Function in Patients with Traumatic Brain Injury

* 10-CC-0217:
A Comparison of Methods for Assisting Needle Angle Selection During Image-Guided Tissue Biopsy

* 10-CC-0153:
Noninvasive Imaging of Heart Failure

* 10-CC-0150:
Effects of Rapid-Resisted Exercise on Ambulatory Adults with Traumatic Brain Injury

* 10-CC-0149:
Comparing Expectorated and Induced Sputum and Pharyngeal Swabs for Cultures, AFB Smears, and Cytokines in Pulmonary Nontuberculous Mycobacterial Infection

* 10-CC-0073:
Physical, Functional and Neurological Effects of Two Lower Extremity Exercise Programs in Children with Cerebral Palsy

* 10-CC-0053:
Collection of Bone Marrow from Healthy Volunteers and Patients for the Production of Clinical Bone Marrow Stromal Cell (BMSC) Products

* 09-CC-0217:
Vasti Control of Patellofemoral Kinematics in Patellofemoral Pain Syndrome

* 08-CC-0133:
The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients with Pulmonary Hypertension: Initial Studies for Establishing Guidelines

* 07-CC-0011:
Hypnosis as a Pain and Symptom Management Strategy in Patients with Sickle Cell Disease

* 05-CC-0216:
Prospective Assessment of Functional Status, Psychosocial Adjustment, Health Related Quality of Life and the Symptom Experience in Patients Treated with Allogeneic Hematopoietic Stem Cell Transplantation

* 05-CC-0041:
Endothelial Cell Dysfunction in Pulmonary Arterial Hypertension: Biomarkers, Mechanisms of Disease and Novel Therapeutic Targets

* 04-CC-0070:
Exploring Patient-Provider Trust among Individuals with End-Stage Renal Disease

* 04-CC-0046:
Citrate Effects and Bone Density Studies in Long-Term Apheresis Donors

* 02-CC-0247:
Values at the Bedside: A Survey of European Physicians Regarding Ethical Dilemmas in Clinical Practice

* 00-CC-0165:
Filgrastim-Mobilized Peripheral Blood Stem Cells for Allogeneic Transplantation Using Unrelated Donors Participating in the National Marrow Donor Program (NMDP)

* 91-CC-0117:
Epidemiology, Infectivity and Natural History of Hepatitis C Virus Infection in a Blood Donor Population