This study is NOT currently recruiting participants.
Number
97-DC-0057
Sponsoring Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruitment Detail
Type: Completed Study; data analyses ongoing Gender: Male & Female Min Age: 6 Years Max Age: N/A
Referral Letter Required
No
Population Exclusion(s)
None
Keywords
DNA Samples; Stuttering; DNA Testing; Statistical Analysis; Genetic Analysis; Natural History
Recruitment Keyword(s)
Stuttering
Condition(s)
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute on Deafness and Other Communication Disorders
Researcher intend on studying the genetic basis for stuttering. The goal of the study is to find the genes that help cause stuttering and determine regions of the human genetic make-up (genome) that are linked to stuttering.. To do this researchers will study the patterns of inheritance in families who have had members who stutter.
The study has two objectives.
The first objective is to develop a large collection of DNA samples from individuals in stuttering families, that will include both members that stutter and who do not stutter.
The second objective of the study will be to find out the basic combination of genes (genotype) making up all of the participants DNA. Once this is completed researchers hope to map out and find areas or regions of DNA that are linked to stuttering.
Genetic linkage is the initial step in positional cloning, and the cloning of genes which predispose individuals to stuttering is a long term goal of this research study.<TAB>
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INCLUSION CRITERIA: - Individuals age 8 and older. - Individuals age 6-8 with a family history of persistent stuttering - Have stuttering that persists for a period of 6 months or more or are a family member of that person -For the Phase 2 imaging studies, we will be enrolling up to 25 healthy volunteers to be controls EXCLUSION CRITERIA: - Stuttering only as a young child (before age 5) with no other family members who stutter - Inability to provide informed consent or have a parent/guardian to provide consent - Development of stuttering following trauma to the central nervous system. - Chronic medical conditions that prevent informed consent or clear evaluation of stuttering, including stroke, dementia, and degenerative neurological disease. - Inability to travel to the NIH Clinical Center for Phase 2
- Individuals age 8 and older.
- Individuals age 6-8 with a family history of persistent stuttering
- Have stuttering that persists for a period of 6 months or more or are a family member of that person
-For the Phase 2 imaging studies, we will be enrolling up to 25 healthy volunteers to be controls
EXCLUSION CRITERIA:
- Stuttering only as a young child (before age 5) with no other family members who stutter
- Inability to provide informed consent or have a parent/guardian to provide consent
- Development of stuttering following trauma to the central nervous system.
- Chronic medical conditions that prevent informed consent or clear evaluation of stuttering, including stroke, dementia, and degenerative neurological disease.
- Inability to travel to the NIH Clinical Center for Phase 2
Principal Investigator
Referral Contact
For more information: