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Protocol Details

A Neurobiological Investigation of Patients with Schizophrenia Spectrum Disorders and Their Siblings

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

95-M-0150

Sponsoring Institute

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 55 Years

Referral Letter Required

No

Population Exclusion(s)

Children;
Non-English Speaking

Keywords

Negative Symptoms;
Brain Scans;
Hallucinations;
Delusions;
Psychosis and Schizophrenia;
Natural History

Recruitment Keyword(s)

None

Condition(s)

Schizoaffective Disorder;
Schizophrenia

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Mental HealthNIH Clinical Center

This large ongoing study at NIMH investigates the neurobiology of schizophrenia by identifying susceptibility genes, evaluating their impact on brain function to better understand how to treat and prevent this illness.

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Eligibility

INCLUSION/EXCLUSION CRITERIA:

Inclusion criteria for Siblings (probands and unaffected siblings):

-Probands must have a DSM IV-R diagnosis of schizophrenia,schizoaffective disorder, psychosis N.O.S. or schizophreniform disorder.

-Probands and Siblings must be between the ages of 18 and 55

-Probands and Siblings must be free of major medical illnesses, but may have controlled hypertension, thyroid disease, or diabetes.

-Probands and Siblings must have the cognitive ability to consent for themselves. Those who are judged to have the cognitive ability to consent for themselves at the time of participation, but do not have the legal capacity to consent for themselves may participate if the legal guardian /Legal authorized representative (LAR) provides consent by signing the informed consent form.

-Fluency in English is required.

Exclusion Criteria for Siblings (probands and unaffected siblings):

-Seizure disorder, mental retardation, organic brain damage or other neurological disease.

-History of any (excepting nicotine-related) DSM5-defined moderate to severe substance use disorder (or DSM-IV-defined substance dependence).

-Cumulative lifetime history of any (excepting nicotine-related) DSM5-defined mild substance use disorder (or any DSM-IV-defined substance abuse), either in excess of 5 years total or not in remission for at least 6 months.

-Head trauma with loss of consciousness over 5 minutes from all but genetic sampling.

-Chemotherapy.

-NIMH employees/staff and their immediate family members will be excluded from the study per NIMH policy

Siblings who do not qualify for the 2-day or 1-day study, may participate in the limited phenotyping arm in which only a psychiatric interview and a blood draw for genetic analysis (SCID-DNA) will be performed, case control analysis or be included as part of a trio (one parent, one sibling, one patient) to study genetic transmission from parents to offsprings.. All parents are eligible for the study.

Inclusion Criteria. Healthy Volunteers/Controls

To be eligible for this research study, healthy volunteers must be:

-Between the ages of 18 and 55

-Fluency in English is required

Healthy Controls Exclusion Criteria:

They will not be eligible if:

-They have history of DSM IV-R psychiatric diagnosis or severe chronic medical illness at the time of the study.

-They have a history of any (excepting nicotine-related) DSM5-defined moderate to severe substance use disorder (or DSM-IV-defined substance dependence).

-They have a cumulative lifetime history of any (excepting nicotine-related) DSM5-defined mild substance use disorder (or any DSM-IV-defined substance abuse), either in excess of 5 years total or not in remission for at least 6 months.

-They may not be eligible for the 2-day or 1-day study if they have a first-degree relative with history of schizophrenia spectrum disorders. However, they may be included in the SCID_DNA or case control analyses.

-Healthy volunteers must be free of learning disabilities.

-NIMH employees/staff and their immediate family members will be excluded from the study per NIMH policy.


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Citations:

Genetic principles and methods in high-risk studies of schizophrenia

Impaired attention, genetics, and the pathology of schizophrenia

Deviant eye tracking in twins discodant for psychosis

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Contacts:

Principal Investigator

Referral Contact

For more information:

Karen F. Berman, M.D.
National Institute of Mental Health (NIMH)



Joann G. Berkson, R.N.
National Institute of Mental Health (NIMH)
National Institutes of Health
Building 10
Room 7-3333
10 Center Drive
Bethesda, Maryland 20892
(301) 451-0167
berksonj@mail.nih.gov

CBDB
National Institutes of Health
Building 10
MSC 1377
Bethesda, Maryland 20892
(888) 674-6464
schizophrenia@intra.nimh.nih.gov

Clinical Trials Number:

NCT00001486

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