This study is currently recruiting participants.
Number
89-N-0045
Sponsoring Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 18 Years Max Age: 120 Years
Referral Letter Required
No
Population Exclusion(s)
Children
Keywords
Multiple Sclerosis; MRI (Magnetic Resonance Imaging); Natural History
Recruitment Keyword(s)
None
Condition(s)
Multiple Sclerosis
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Neurological Disorders and Stroke
A second cohort of patients starting the use of approved therapy will also be examined. Patients referred to NIH prior to beginning approved therapy will be assessed with a series of three monthly MRIs to determine the level of pretreatment disease activity. After beginning approved therapy under the direction of their private physician, patients will be followed similarly to the natural history cohort. Immunological and genetic findings will be accessed before and during therapy in order to help establish the mechanisms of action of the therapies and to identify mechanisms accounting for either a response or lack of response to therapy. Part of the collected samples willl be cryopreserved to provide respository for further studies focusing on detection of biomarkers indicative of disease state, disease stage or repsonse to therapies.
Additionally, a cohort of normal volunteers will be studied. The studies in the normal volunteers will be used to establish the most appropriate imaging sequences for studying normal white matter in MS patients using magnetization transfer (MT) imaging sequences for studying normal white matter in MS patients using magnetization transfer (MT) imaging and to provide normative immunological measures.
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INCLUSION CRITERIA: -One of the following: --Diagnosis of MS or clinically isolated syndrome based on currently accepted diagnostic criteria. --Presentation with neuroimaging features consistent with MS. --Diagnosis of another disease of the CNS --Healthy volunteer. -Age greater than or equal to 18. -Able to give informed consent. NIH employees are eligible to participate. EXCLUSION CRITERIA: -Contraindication to MRI. -Pregnancy. -Unwilling to allow coded samples to be processed offsite or unwilling to have coded samples used in other studies.
-One of the following:
--Diagnosis of MS or clinically isolated syndrome based on currently accepted diagnostic criteria.
--Presentation with neuroimaging features consistent with MS.
--Diagnosis of another disease of the CNS
--Healthy volunteer.
-Age greater than or equal to 18.
-Able to give informed consent.
NIH employees are eligible to participate.
EXCLUSION CRITERIA:
-Contraindication to MRI.
-Pregnancy.
-Unwilling to allow coded samples to be processed offsite or unwilling to have coded samples used in other studies.
Principal Investigator
Referral Contact
For more information: