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Protocol Details

Studies on Thyroid Nodules and Thyroid Cancer

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

77-DK-0096

Sponsoring Institute

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 6 mo
Max Age: N/A

Referral Letter Required

No

Population Exclusion(s)

None

Special Instructions

Only a limited number of patients are being recruited at the present time. Our major research focus is the diagnosis and treatment of clinically aggressive thyroid cancer. Current research aims are focusing on patients requiring dosimetry measurements, patients with iodine non-avid disease, as well as patients with progressive disease despite optimal prior surgical and radioiodine therapies.

If interested, have your health care provider send a written referral letter summarizing your thyroid disorder plus all applicable laboratory, radiology, and nuclear medicine reports. All biopsy or surgery pathology reports AND relevant slides must be included. This information will be reviewed by Principal Investigator to determine whether you are eligible for protocol enrollment.

Keywords

Thyroid Fine Needle Biopsy;
Radioiodine;
Dosimetry

Recruitment Keyword(s)

None

Condition(s)

Hurthle Cell Thyroid Cancer;
Tall Cell Variant Thyroid Cancer;
Follicular Thyroid Cancer;
Thyroid Cancer;
Papillary Thyroid Cancer

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Diabetes and Digestive and Kidney Diseases

Participants in this study will be patients diagnosed with or suspected to have a thyroid nodule or thyroid cancer.

The main purpose of this study is to further understand the methods for the diagnosis and treatment of thyroid nodules and thyroid cancer. Many of the test performed are in the context of standard medical care that is offered to all patients with thyroid nodules or thyroid cancer. Other tests are performed for research purposes. In addition, blood and tissue samples will be taken for research and genetic studies.

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Eligibility

INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Male or female, adults or children >= 6 months+.

2. Patients with known or suspected thyroid nodules and/or thyroid cancer.

3. At risk family members of patients who have a genetic susceptibility to developing thyroid cancer.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Serious underlying medical conditions that restrict diagnostic testing or therapy such as renal failure, congestive cardiac failure or active coexisting non-thyroid carcinoma requiring intervention before thyroid cancer is addressed.


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Citations:

Klubo-Gwiezdzinska J, Wartofsky L. The Role of Molecular Diagnostics in the Management of Indeterminate Thyroid Nodules. J Clin Endocrinol Metab. 2018 Sep 1;103(9):3507-3510. doi: 10.1210/jc.2018-01081. PMID: 30032182; PMCID: PMC6456919.

Thakur S, Tobey A, Daley B, Auh S, Walter M, Patel D, Nilubol N, Kebebew E, Patel A, Jensen K, Vasko V, Klubo-Gwiezdzinska J. Limited Utility of Circulating Cell-Free DNA Integrity as a Diagnostic Tool for Differentiating Between Malignant and Benign Thyroid Nodules With Indeterminate Cytology (Bethesda Category III). Front Oncol. 2019 Sep 18;9:905. doi: 10.3389/fonc.2019.00905. PMID: 31620364; PMCID: PMC6759775.

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Contacts:

Principal Investigator

Referral Contact

For more information:

Joanna Klubo-Gwiezdzinska, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
BG 10 RM 9C103
10 CENTER DR
BETHESDA MD 20814
(301) 496-5052
joanna.klubo-gwiezdzinska@nih.gov

Padmasree Veeraraghavan, N.P.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institutes of Health
Building 10
Room 9C103
10 Center Drive
Bethesda, Maryland 20892
(301) 451-7710
padmasree.veeraraghavan@nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010
PRPL@cc.nih.gov

Clinical Trials Number:

NCT00001160

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