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Protocol Details

Development of Immersive VR Environments to Induce and Evaluate Cognitive Fatigability: User Experience and Healthy Control Studies

This study is NOT currently recruiting participants.

Summary | Eligibility | Citations | Contacts




Sponsoring Institute

National Institute of Nursing Research (NINR)

Recruitment Detail

Type: No longer recruiting/follow-up only
Gender: Male & Female
Min Age: 18
Max Age: 75

Referral Letter Required


Population Exclusion(s)



Emotional Regulation;
Cognitive Interference;
Behavioral Regulation;
Stress Impact on Cognition;
Natural History

Recruitment Keyword(s)



Cognitive Fatigue

Investigational Drug(s)


Investigational Device(s)




Supporting Site

National Institute of Nursing Research


Immersive virtual reality (VR) technology is used by researchers to measure how people respond to complex stimuli in a controlled environment. Cognitive fatigue (CF) can result in serious consequences such as mistakes and accidents. Researchers want to see if VR can be used to learn more about CF.


To test the user experience of a VR program designed to study individual differences in the susceptibility to develop CF in healthy people while performing activities of daily living.


Healthy adults ages 18-75 from the Washington Metropolitan area


Participants will be screened with questions about their health and medical history.

The VR program simulates a real-world grocery shopping environment. Participants will be given a shopping task.

Participants will be seated. They will wear a head-mounted display (HMD) for 1.5 hours. The device is worn on the head. It presents images to the eyes. Eye-tracking data may be collected through the HMD.

The following will happen in the VR environment:

-Participants will be seated at a kitchen table. They will complete a pillbox task 2 times.

-Participants will be placed in a small grocery store. They will be trained how to use the controllers to shop.

-Participants will appear to be seated in front of a screen. They will be shown how to answer questions about how tired they feel and if the tasks are hard to do.

-Participants will be placed in a large grocery store. They will complete a shopping task.

Participants will complete surveys. They will also answer questions about the VR experience.

Participants will have 1 or 2 study visits. It will last 3-4 hours total.

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Male or female participant aged 18-75

Willingness to complete study procedures

Willing to provide feedback about VR experiences

Able to provide his/her own consent


Not fluent in English

Any impairment in visual functioning (e.g., 3-d depth perception, visual acuity, oculomotor control) not corrected with lenses

Eye pain or iritis

Susceptibility to photogenic seizures and/or diagnosis of seizure disorder

Inability to use hands to manipulate objects

Diagnosis of a neurological condition

Diagnosis of a sleep disorder

Current treatment for chronic physical pain, migraines, any diagnosis of a clinical condition associated with cognitive or physical fatigue (e.g. multiple sclerosis, chronic fatigue syndrome, etc.)

Any history of acquired brain injury

Current cold/flu symptoms

NINR employee/staff or subordinate, relative, and/or co-worker of NINR employee/staff or a study investigator.

For phase 2, participation in phase 1

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Not Provided

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Principal Investigator

Referral Contact

For more information:

Patricia Brennan, Ph.D.
National Institute of Nursing Research (NINR)
National Institutes of Health
Building 38
Room 2E17B
38 Library Drive
Bethesda, Maryland 20892
(301) 496-6221

Stephanie R. Burrison, R.N.
National Institute of Nursing Research (NINR)
National Institutes of Health
Building 10
Room 4S233
10 Center Drive
Bethesda, Maryland 20892
(202) 941-8728

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1

Clinical Trials Number:


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