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Protocol Details

Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

20-N-0105

Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 50 Years

Referral Letter Required

No

Population Exclusion(s)

Pregnant Women;
Non-English Speaking;
Children

Keywords

Healthy;
Learning Consolidation;
Brain;
Natural History

Recruitment Keyword(s)

None

Condition(s)

Normal Physiology

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Neurological Disorders and Stroke

Background:

Training in a new motor skill often involves periods of active practice and periods of rest. During early motor skill learning, improvements in performance usually happen during the short rest periods between practice sessions. Researchers want to use improved imaging techniques to study the contributions of specific parts of the brain to how people learn and retain movement skills.

Objective:

To learn the part played by different layers in the brain in retaining a newly learned movement skill.

Eligibility:

Healthy, right-handed, English-speaking people age 18-50.

Design:

Participants will be screened with:

-Medical and neurological history

-Medicine review

-Physical exam

-Neurological exam.

Participants may have 2 magnetic resonance imaging (MRI) scans of the brain. During the MRI, they will lie in the scanner. The scanner makes noise. They will get earplugs.

Participants will have behavior testing. A specific order of keys will be displayed on a computer screen. Participants will practice typing the keys with their left hand 36 times (in 10-second blocks). They will repeat this test with a random order of keys.

Participants will see single numbers displayed one after the other on the computer screen. They will make single tap responses using the finger that corresponds with the number on the screen.

Participants will have up to 4 study sessions. Each session will take about 5 hours.

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Eligibility

INCLUSION CRITERIA:

- Age 18-50

- English speaking

- Right-hand dominance (>74 on Edinburgh Handedness Inventory)

- Normal neurological examination

- Willing and able to provide informed consent

EXCLUSION CRITERIA:

- HCPS-affiliated NIH staff (i.e. - staff from our section).

- Current pregnancy

- Current or past history of use of antiepileptic drugs

- Contraindications for MRI (such as certain implants, metal fragments or devices in the body) as determined by the screening clinician

- Severe or progressive neurological, psychological or medical condition


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Citations:

Not Provided

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Contacts:

Principal Investigator

Referral Contact

For more information:

Leonardo G. Cohen, M.D.
National Institute of Neurological Disorders and Stroke (NINDS)
NIHBC 10 - CLINICAL CENTER BG RM 7D54
10 CENTER DR
BETHESDA MD 20892
(301) 496-9782
cohenl1@mail.nih.gov

Tasneem F. Malik, C.R.N.P.
National Institute of Neurological Disorders and Stroke (NINDS)
NIHBC 10 - CLINICAL CENTER BG RM 7D51
10 CENTER DR
BETHESDA MD 20892
(301) 451-1335
tasneem.malik@nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1
ccopr@nih.gov

Clinical Trials Number:

NCT04431011

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