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Protocol Details

Mechanisms Underlying the Beneficial Effects of Naps on Motor Learning

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

20-N-0060

Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18
Max Age: 80

Referral Letter Required

No

Population Exclusion(s)

Children

Special Instructions

Currently Not Provided

Keywords

Motor Skill;
Sleep;
Neural Replay

Recruitment Keyword(s)

None

Condition(s)

Stroke

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Neurological Disorders and Stroke

Background:

Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows that daytime naps improve people s motor performance and memory retention. Researchers want to find out how daytime naps may contribute to learning and support consolidation of motor skill memories.

Objective:

To learn the role of memory replay during wakeful rest and sleep (naps) in retaining a newly learned skill.

Eligibility:

English-speaking adults ages 18 and older with chronic stroke, or healthy, right-handed, English-speaking adults ages 18-35 and 50-80

Design:

Participants will be screened with:

-medical history

-neurological history

-medicine review

-medical exam

-neurological exam.

Participants will have a magnetic resonance imaging (MRI) scan of the brain. For this, they will lie down in a scanner. The scanner makes loud noises, so they will wear earplugs. They will fill out an MRI screening form before each MRI.

Participants will also have magnetoencephalography (MEG). MEG maps brain activity. It does this by recording the magnetic fields produced by naturally occurring electrical currents in the brain. For MEG, participants will lie down in the MEG room. Their eye movements may be recorded by a video camera.

Participants will have behavior testing. They will practice typing random keys. Then they will repeatedly type a custom sequence that they see on a computer screen. Then they will take a 2-hour nap. Then they will type the same sequence again.

Participants will have no more than 4 visits at the NIH over 3 months. Visits will last 2-4 hours each.

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Eligibility

HEALTHY VOLUNTEERS:

INCLUSION CRITERIA:

-Age 18-35 (Arm 1) or 50-80 (Arm 2)

-English speaking

-Clear right-hand dominance (>74 on Edinburgh Handedness Inventory)

-Normal neurological examination as determined by the screening clinician

EXCLUSION CRITERIA:

-HCPS-section affiliated NIH staff

-Current pregnancy

-Contraindications for MRI or MEG.

-Use of sleep medications within 24 hours of Experimental Session participation

-Severe or progressive neurological, psychological or medical condition as determined by the screening clinician.

STROKE PATIENTS:

INCLUSION CRITERIA:

-Age 18 or older

-Willing and able to provide consent

-Experienced a stroke 6 months ago or more that affected at least one of the upper extremities at time of stroke diagnosis

-Ability to perform the study task as assessed during physical examination

-English-speaking

EXCLUSION CRITERIA:

-HCPS-affiliated NIH staff.

-Current pregnancy

-History of large stroke in brainstem or cerebellum

-Severe or progressive neurological disorder other than stroke (e.g., Parkinson s disease or multiple sclerosis)

-Uncontrolled heart, lung, kidney, gastrointestinal, metabolic, psychiatric, sleep, or endocrine disorders

-Contraindications for MRI or MEG.


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Citations:

Not Provided

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Contacts:

Principal Investigator

Referral Contact

For more information:

Leonardo G. Cohen, M.D.
National Institute of Neurological Disorders and Stroke (NINDS)



Margaret K. Hayward, C.R.N.P.
National Institute of Neurological Disorders and Stroke (NINDS)
NIHBC 10 - CLINICAL CENTER BG RM 7D51B
10 CENTER DR
BETHESDA MD 20892
(301) 451-1335
HCPS.research@nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010
PRPL@cc.nih.gov

Clinical Trials Number:

NCT04312126

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