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Protocol Details

Modulating the Hippocampal and Striatal Memory Networks with rTMS

This study is NOT currently recruiting participants.

Summary | Eligibility | Citations | Contacts




Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Completed Study; data analyses ongoing
Gender: Male & Female
Min Age: 20
Max Age: 40

Referral Letter Required


Population Exclusion(s)

Pregnant Women and Fetuses;
Non-English Speaking

Special Instructions

Currently Not Provided


Memory Systems;
Repetitive Transcranial Magnetic Stimulation;
Behavioral Efficiency;
Hippocampal and Striatal Memory Networks

Recruitment Keyword(s)



Normal Behavioral Patterns

Investigational Drug(s)


Investigational Device(s)



Other: RTMS

Supporting Site

National Institute of Neurological Disorders and Stroke


People have 2 memory systems. One helps them learn skills and the other helps them learn facts. Repetitive transcranial magnetic stimulation (rTMS) uses electronic currents to activate brain cells. This can make small changes in how brain systems operate. Researchers will use rTMS to change how memory systems work and to see if changing one system causes the other to change too. This could help find ways to improve learning and memory in people with memory disorders.


To learn how different memory systems work with each other.


Healthy adults ages 18-40 who are not pregnant


Potential participants will be screened with a neurological exam if they haven t had one from NINDS in the past 2 years. They may have urine tests.

Eligible participants will have 5-10 visits at NIH. Each visit will last 1-6 hours. Visits 1-4 will each take place 1 day apart.

At visit 1, participants will have an MRI and take memory tests. For MRI, they will lie on a table that slides in and out of a cylinder that takes pictures of their brain. They will also have rTMS. For rTMS, a metal coil is held on their scalp. Brief electrical currents pass through the coil.

At visits 2 and 3, participants will have rTMS.

At visit 4, participants will have an MRI and do memory tests.

About a week later, participants will have visit 5. They will have an MRI and do memory tests. Participants may be asked to have more visits if any technical problems occur. Participants involvement will last 2 weeks.

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-Age 18-40 (inclusive)


-Any current major neurological or psychiatric disorder such as (but not limited to) stroke, Parkinson disease, Alzheimer disease, schizophrenia or major depression

-History of seizure

-Medications acting on the central nervous system, such as those that lowers the seizure threshold such as neuroleptics, beta lactams, isoniazid, metronidazole; benzodiazepines, tricyclic or other antidepressants; or prescription stimulants.

-Ferromagnetic metal in the cranial cavity or eye, implanted neural stimulator, cochlear implant, or ocular foreign body

-Implanted cardiac pacemaker or auto-defibrillator or pump

-Non-removable body piercing


-Inability to lie supine for 2 hours

-Pregnancy, or plans to become pregnant during the study.

-Members of the NINDS BNU

-Subjects that received rTMS under protocol 17-N-0055 are excluded in order avoid learning effects from previously being exposed to the same behavioral tasks

-Subjects who have contraindications to MRI (we will follow the NMR Center guidelines for MR safety). Some of the exclusions are:

--Have non-MRI compatible metal in the body, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain or on blood vessels, cochlear implants, artificial heart valves or ferromagnetic fragments in the eye or oral cavity as these make having an MRI unsafe.

--Unable to lie flat on the back for the expected length of the experiment (2 hours).

--Have an abnormality on the brain imaging or neurologic examination not related to the diagnosis.

--Non-removable body piercing or

--Pregnancy (urine pregnancy test)

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Not Provided

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Principal Investigator

Referral Contact

For more information:

Eric M. Wassermann, M.D.
National Institute of Neurological Disorders and Stroke (NINDS)

Cynthia M. Fioriti
National Institute of Neurological Disorders and Stroke (NINDS)
BG 10 RM 7D48
(301) 496-0220

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010

Clinical Trials Number:


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