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Protocol Details

Translational Development of Photon-Counting CT Imaging

This study is NOT currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

19-CC-0070

Sponsoring Institute

National Institutes of Health Clinical Center (CC)

Recruitment Detail

Type: Completed Study; data analyses ongoing
Gender: Male & Female
Min Age: 18 Years
Max Age: N/A

Referral Letter Required

Yes

Population Exclusion(s)

Children

Keywords

Photon Counting CT;
Computed Tomography;
Photon Counting Detectors

Recruitment Keyword(s)

None

Condition(s)

Cancer;
Inflammatory Disease;
Vascular Disease;
Metabolic Bone Disease

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

Device: PHOTON COUNTING CT Scanner

Supporting Site

NIH Clinical Center

Using an investigational CT scanner which uses a new type of detector to capture X-rays, (a photon counting CT detector), the goal of this experimental study is to compare conventional CT images to CT images using the photon counting detector in patients undergoing CT scans for clinically indicated reasons. The main question it aims to answer is whether the images produced using the new detectors are superior in quality. Participants will undergo the clinically indicated CT images and the photon counting detector CT images of a limited area during the same examination time.

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Eligibility

INCLUSION CRITERIA:

- NIH patients currently on an NIH research protocol who are referred to RAD&IS for CT examination as part of that research protocol

- 18 years old or greater

- Able to understand and sign informed consent

EXCLUSION CRITERIA:

- Studies that specifically require simultaneous dual source CT scan capability or where dual source CT scan is requested

- Studies ordered for an emergency indication

- Pregnant women. Subjects of child-bearing potential will undergo serum or urine pregnancy testing within 72 hours before examination. Post-menopausal and surgically sterilized subjects are automatically exempt from this testing

- Lactating women who are unable to stop breast feeding for 24 hours following the administration of contrast

- Body weight >500 lbs (227 kg) or a body circumference that prevents the study subject from lying flat in the scanner

- Patients who have undergone PCCT examination within the past year.

- Any contraindications that the research team identifies from the subject, RAD&IS CT questionnaires, and/or History and Assessment

- Employees or staff supervised by the Principal Investigator or an Associate will not be recruited to participate


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Citations:

Symons R, Pourmorteza A, Sandfort V, Ahlman MA, Cropper T, Mallek M, Kappler S, Ulzheimer S, Mahesh M, Jones EC, Malayeri AA, Folio LR, Bluemke DA. Feasibility of Dose-reduced Chest CT with Photon-counting Detectors: Initial Results in Humans. Radiology. 2017 Dec;285(3):980-989. doi: 10.1148/radiol.2017162587. Epub 2017 Jul 28.

Pourmorteza A, Symons R, Henning A, Ulzheimer S, Bluemke DA. Dose Efficiency of Quarter-Millimeter Photon-Counting Computed Tomography: First-in-Human Results. Invest Radiol. 2018 Jun;53(6):365-372. doi: 10.1097/RLI.0000000000000463.

Pourmorteza A, Symons R, Reich DS, Bagheri M, Cork TE, Kappler S, Ulzheimer S, Bluemke DA. Photon-Counting CT of the Brain: In Vivo Human Results and Image-Quality Assessment. AJNR Am J Neuroradiol. 2017 Dec;38(12):2257-2263. doi: 10.3174/ajnr.A5402. Epub 2017 Oct 5.

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Contacts:

Principal Investigator

Referral Contact

For more information:

Elizabeth C. Jones, M.D.
National Institutes of Health Clinical Center (CC)
NIHBC 10 - CLINICAL CENTER BG RM 1C355
10 CENTER DR
BETHESDA MD 20892
(301) 402-5606
ejones@cc.nih.gov

Tracy L. Cropper, R.N.
National Institutes of Health Clinical Center (CC)
National Institutes of Health
Building 10
Room 1C512
10 Center Drive
Bethesda, Maryland 20892
(301) 402-6132
tcropper@cc.nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1
ccopr@nih.gov

Clinical Trials Number:

NCT03878134

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